Protein Alignment Nepl8 and nep-1

DIOPT Version :9

• Sequence 1: NP_609795.2
• Gene: Nepl8 / 34983
• FlyBaseID: FBgn0032585
• Length: 619
• Species: Drosophila melanogaster
• Sequence 2: NP_496490.2
• Gene: nep-1 / 174787
• WormBaseID: WBGene00013926
• Length: 754
• Species: Caenorhabditis elegans
• Alignment Length: 737
• Identity: 137/737 - (18%)
• Similarity: 259/737 - (35%)
• Gaps: 195/737 - (26%)

  Fly    18 TRLLNGILSHVDKEANPCENYYNHACGQYNMRH--IDD-TFFDIIQMLDHQVNQNLVKLMDELEM 79
            :|||.   ..::...:||::::.:||..:...|  .|| |.:........:|...:.||.::
 Worm    73 SRLLQ---KSLNLSLDPCDDFFEYACRAWVDSHPIPDDLTSYSQFTATREKVLAEMRKLYED--- 131

  Fly    80 SSQLPDFNVSSVDGKVLRYYLSCR--------GAPRNMDSLSQYLKVISPGEGLTWPQFIPDGSS 136
            ::.:|   .|.....:.:.|.:|.        ||...::.:..|        |. ||  :.....
 Worm   132 NTSIP---TSKSIALIKQIYNTCMDTEKHNAVGARDLLEKIKTY--------GY-WP--MVHNEK 182

  Fly   137 WPQENFKWLKALAHLHRYGLTNVFFNLEVVSNPRNASEYMVELNTPTFG---------------- 185
            |.:..|...|.|::..:....:|||:.....:.||.|..::..:..:.|
 Worm   183 WRESTFDLTKLLSNTIQSRDVSVFFDFGPAEDSRNVSRRLLSFDQGSLGLGYSTRDYYLDEKKYE 247

  Fly   186 -------------------------EESQLPNSFIEILSVLYIIKVPSSEIITLARKMRTLELLL 225
                                     .||::.:...||::    .:...::|:......|....|.
 Worm   248 KQMKAYRKYTIGKVRYYTEDAGMAVNESKIESDVDEIIA----FEKEWAQILVAEEDRRNYTKLY 308

  Fly   226 KTMINPIDTLNNRYISIRDFQMETGHNWQRF----FEILIGSSAAPELQVLVRNFRYFTALKELM 286
            .  :...|.| ..|:||.|        |::.    ...|:.|.......:::.:..|...:..|:
 Worm   309 N--VRRFDDL-KEYMSIID--------WKKLTLSTTPFLVHSYLKTNPSIIISDVEYLQKMNTLL 362

  Fly   287 DKQDARLVASYIMTRFAIFLLDE--------------TMGGRES-----TECVSQVRRNMNLAAN 332
            ...|.|:|.:||:.|:|.....|              .|.||:.     .:|||.....::.|:.
 Worm   363 QNTDPRIVTNYILLRWAGSWSQEIGKKYEDLQQEFAFQMYGRKQRQPRWKDCVSSAGGKLSYASG 427

  Fly   333 MLYKERFFEDSTFSANILEIKDIFEKLRHQFLLQVDQNHLE--LTALQMKFFVRKAEAI--EIN- 392
            .:|..::|:.:..:..:..|.|:.|..|:..       |..  :.|...|:.:.||:.:  :|.
 Worm   428 SMYVRKYFDANAKNTTLDMITDLQEAFRNMM-------HANDWMDAETKKYALEKADQMLKQIGY 485

  Fly   393 ---VVNLPKTDDLRHFIGQYYQDLQFPTGELDYHQEHLKVLQFRT----QKMLAQSSKGHSEEQN 450
               ::|..|.||       :|:.|: ...|..:.|...|.:|:|.    :::|        |..|
 Worm   486 PDFILNDEKLDD-------WYKGLE-GAPEDSFSQLVEKSIQWRNNFYYRRLL--------EPVN 534

  Fly   451 ILTYRSQAAPLPP----------------PQPFFQLESEDVFKYSLMGYIMAHHLISAFATEGIT 499
            ...:.|.||.:..                .||||.........|..:|.::.|.:...|...|..
 Worm   535 RFEFISSAAVVNAFYSPTRNAIAFPAGILQQPFFDARFPKALNYGGIGAVIGHEITHGFDDTGRQ 599

  Fly   500 IGSDGNDQSF----RSHRFEEAVSCLSRNSENI---------------DESMGDIAGLELAYFTY 545
            ..:.||.:.:    .|.:|.|...|:.....::               .|::.|..|::.|:..|
 Worm   600 FDNVGNLRDWWDNTTSSKFNERTQCIIEQYADVKLRGTDLRINGKLTQGENIADNGGIKQAFKAY 664

  Fly   546 ----AKMAKNRNRL-DFTHLPPEQIFFLNVGQFFCG-----NSDMLV---QYKEDQVRLQRAIEG 597
                .|......|| .|..|..||:||:...|.:||     ...:|:   .:..:..|:...:..
 Worm   665 KSYLEKHGGQEARLPQFESLTNEQLFFVGYAQVWCGAKTPETKTLLLLTDPHSPETARVNTVLTN 729

  Fly   598 FEPFDKAFGCYRNKPKH--EKC 617
            ...|.:||.|....|.:  ::|
 Worm   730 QPEFAEAFKCPAGSPMNPTKRC 751

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl8	NP_609795.2	GluZincin	32..618	CDD:301352	134/723 (19%)
nep-1	NP_496490.2	PepO	80..754	CDD:226118	134/727 (18%)
		M13	85..751	CDD:189000	133/720 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910