Protein Alignment Nepl8 and nep-5

DIOPT Version :10

• Sequence 1: NP_609795.2
• Gene: Nepl8 / 34983
• FlyBaseID: FBgn0032585
• Length: 619
• Species: Drosophila melanogaster
• Sequence 2: NP_001364754.1
• Gene: nep-5 / 173933
• WormBaseID: WBGene00017393
• Length: 694
• Species: Caenorhabditis elegans
• Alignment Length: 701
• Identity: 139/701 - (19%)
• Similarity: 237/701 - (33%)
• Gaps: 233/701 - (33%)

  Fly    24 ILSHVDKEANPCENYYNHACGQYNMRHIDDTFFDIIQMLDHQVNQNLVKLMDELEMSSQLPDFNV 88
            :|..:|...|||||:::|.|..:|.|..|              .:.|:||::..|........||
 Worm   120 LLELMDSSVNPCENFHHHVCNGFNPRKKD--------------FERLMKLINIQEKPDHRKAVNV 170

  Fly    89 SSVDGKVLRYYLSC-RGAPRNMDSLSQYLKVISPGEGLTWPQFIPDGSSW--PQE---------- 140
                  |.|....| .|....:..:.:...:|.|  ||.:|..   .:||  |.:
 Worm   171 ------VRRMLSKCAMGKTEEIHQVGRLSSIILP--GLPFPLL---NNSWTKPSDPISTSNSSTT 224

  Fly   141 -NFKWL-KALAH--LHR------YGL---TNVFFNLEVV---------------------SNPRN 171
             ::.:| |.|||  ||.      .|:   ::..|:|.||                     :.|.:
 Worm   225 YSYPFLTKILAHIILHNPDDAGFVGIKPSSDSEFSLFVVKPFSPVLTNFKFRNMYDILKRNAPES 289

  Fly   172 ASEYMVELNTPTFGEESQLPNSFIEILSVLYIIKVPSS-EIITLARKMRTLELLLKTMINPIDTL 235
            ::..|::|.   |..:.|| |..|::.:.|..|:..:. |::.|....|.:.::
 Worm   290 STNGMIDLE---FDRQRQL-NDVIKLQTKLEKIEFKADPEVVNLTEIQRQMPII----------- 339

  Fly   236 NNRYISIRDFQMETGHNWQRFFEILIGSSAAPELQVLVRNFR--YFTALKELMDKQDARLVASYI 298
                            :|:|..:..|.:..| .|:..|..|.  |:..:..::....:..:.:::
 Worm   340 ----------------DWKRLIDSWIPNGYA-HLKEKVYGFNTSYYEEINAIISSTPSETIYNFL 387

  Fly   299 MTRFAI-FLLDETMGGRESTECVSQVRRN---------------MNLAANMLYKERFFEDSTFSA 347
            ..||:. ||..|.....|.| |:.|:...               :||...||:
 Worm   388 FLRFSFKFLRTEVASDLEDT-CLHQLSTTIPGKIVLYGSEEPEALNLLNGMLH------------ 439

  Fly   348 NILEIKDIFEKLRHQF--LLQVDQNHLELTALQMKFFVRKAEAIEINVVNLPKTDDLRHFIGQYY 410
               .|||   :|:...  |..:|...:|  ..|.||...|      .|......|.:...:|:.
 Worm   440 ---TIKD---QLKRSLATLKWMDSRGIE--EAQKKFNKTK------TVFGFTGEDLIDELVGKI- 489

  Fly   411 QDLQFPTGELDYHQEHLKVLQFRTQKMLAQSSKG-----------HSEEQN-------ILTYRSQ 457
                  |.|.:|......||.::|:.|....::.           :|.|:|       :|.|...
 Worm   490 ------TPESNYISTLQNVLLWQTRNMFKSVAENNVTVFLNSEVFYSVEKNEITISRALLHYPFM 548

  Fly   458 AAPLPPPQPFFQLESEDVFKYSLMGYIMAHHLISAFATEGITIGSDGNDQSF----RSHRFEEAV 518
            :|.||....|..:.|:           :...:|..|...|....||||.:::    ....|:..|
 Worm   549 SANLPNYTNFATIASK-----------ILPQMIHIFDERGRFYDSDGNHRNWWNTETERYFQIIV 602

  Fly   519 SCLSRNSENIDESMGDIAGLELAYFTYAKMAKNRNRLDFTHLP-----------PEQIFFLNVGQ 572
            .|       .|..|.::.|:.::.        ..|..|.|..|           .|.:||.::.:
 Worm   603 QC-------FDGMMQNVFGVSVSI--------GWNAYDSTKEPYATLPGIQQSSDEALFFYSMVK 652

  Fly   573 FFCGNSDMLVQYKEDQVRLQRAIEGFEPFDKAFGCYR----NKPKHEKCRL 619
            ..|         ..|...:..|:.....|:.||.|..    |.|  .||:|
 Worm   653 TMC---------TSDPDNVNEALASVPQFNSAFKCNNGTKMNPP--TKCKL 692

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl8	NP_609795.2	GluZincin	32..618	CDD:472708	135/690 (20%)
nep-5	NP_001364754.1	GluZincin	128..691	CDD:472708	135/690 (20%)