Protein Alignment Nepl8 and Mme

DIOPT Version :10

• Sequence 1: NP_609795.2
• Gene: Nepl8 / 34983
• FlyBaseID: FBgn0032585
• Length: 619
• Species: Drosophila melanogaster
• Sequence 2: NP_032630.2
• Gene: Mme / 17380
• MGIID: 97004
• Length: 750
• Species: Mus musculus
• Alignment Length: 769
• Identity: 172/769 - (22%)
• Similarity: 295/769 - (38%)
• Gaps: 211/769 - (27%)

  Fly     3 IICLLLVPLVA--------ASSNTRLLNGILSHVDKEANPCENYYNHACGQYNMRH-IDDTF--- 55
            ||.:.::.|.|        :|...:....::.::|....||.:::.:|||.:..|: |.:|.
Mouse    40 IIAVTMIALYATYDDGICKSSDCIKSAARLIQNMDASVEPCTDFFKYACGGWLKRNVIPETSSRY 104

  Fly    56 --FDIIQMLDHQVNQNLVKLMDELEMSSQLPDF-------NVSSVDGKVLRYYLSC--------R 103
              |||              |.||||:.  |.|.       ::.:|. |....|.||        |
Mouse   105 SNFDI--------------LRDELEVI--LKDVLQEPKTEDIVAVQ-KAKTLYRSCINESAIDSR 152

  Fly   104 GAPRNMDSLSQYLKVISPGEGLTWPQFIPD-----GSSWPQENFKWLKALAHLH-RYGLTNVFFN 162
            |.       ...||::....|  ||....:     |:||..|     |::|.|: :|| ..|..|
Mouse   153 GG-------QPLLKLLPDIYG--WPVASDNWDQTYGTSWTAE-----KSIAQLNSKYG-KKVLIN 202

  Fly   163 LEVVSNPRNASEYMVELNTPTFGEESQLPN---------------SFIE-ILSVLYIIKVPSSEI 211
            ..|.::.:|::::::..:.|..|    ||:               :::: ::||..:|:...|..
Mouse   203 FFVGTDDKNSTQHIIHFDQPRLG----LPSRDYYECTGIYKEACTAYVDFMISVARLIRQEQSLP 263

  Fly   212 I---TLARKMRTLELLLKTMIN----PID-----TLNNRYISIR---DFQMET---GHNWQRFF- 257
            |   .|:.:|..:..|.|.:.|    |.|     .|.|:....:   :|.:|.   ..:|..|.
Mouse   264 IDENQLSLEMNKVMELEKEIANATTKPEDRNDPMLLYNKMTLAKLQNNFSLEVNGKSFSWSNFTN 328

  Fly   258 EIL--IGSSAAPELQVLVRNFRYFTALKELMDKQDARLVASYIMTRFAIFLLD------------ 308
            ||:  :..:...|.:|:|....|.|.||.::.|...|.:.:.:..||.:.|:.
Mouse   329 EIMSTVNINIQNEEEVVVYAPEYLTKLKPILTKYSPRDLQNLMSWRFIMDLVSSLSRNYKESRNA 393

  Fly   309 --ETMGGRES-----TECVSQVRRNMNLAANMLYKERFFEDSTFSANILEIKDIFEKLRHQFLLQ 366
              :.:.|..|     ..|.:.|..||..|...||.|..|...  |.:::|  |:..::|..|:..
Mouse   394 FRKALYGTTSETATWRRCANYVNGNMENAVGRLYVEAAFAGE--SKHVVE--DLIAQIREVFIQT 454

  Fly   367 VDQNHLELT---ALQMKFFVRKAEAIEINVVNLPKTDDL---RHFIGQYYQDLQFPTGELDYHQE 425
            :|    :||   |...|....||.||: ..:..|  ||:   .:.:...|.:|.:  .|.:|.:.
Mouse   455 LD----DLTWMDAETKKKAEEKALAIK-ERIGYP--DDIISNENKLNNEYLELNY--REDEYFEN 510

  Fly   426 HLKVLQFRTQKML----------------AQSSKGHSEEQNILTYRSQAAPLPPPQPFFQLESED 474
            .::.|:|...|.|                |..:..:|..:|.:.:  .|..|.|  |||..:..:
Mouse   511 IIQNLKFSQSKQLKKLREKVDKDEWISGAAVVNAFYSSGRNQIVF--PAGILQP--PFFSAQQSN 571

  Fly   475 VFKYSLMGYIMAHHLISAFATEGITIGSDGN------DQSFRSHRFEEAVSCLSRNSEN------ 527
            ...|..:|.::.|.:...|...|.....||:      .||  ::.|::...|:.....|
Mouse   572 SLNYGGIGMVIGHEITHGFDDNGRNFNKDGDLVDWWTQQS--ANNFKDQSQCMVYQYGNFSWDLA 634

  Fly   528 ----------IDESMGDIAGLELAYFTYAKMAKNRNR------LDFTHLPPEQIFFLNVGQFFCG 576
                      :.|::.|..|:..||..|....|....      ||..|   :|:||||..|.:||
Mouse   635 GGQHLNGINTLGENIADNGGIGQAYRAYQNYVKKNGEEKLLPGLDLNH---KQLFFLNFAQVWCG 696

  Fly   577 --------NSDMLVQYKEDQVRLQRAIEGFEPFDKAFGCYRN---KPKHEKCRL 619
                    ||.....:.....|:...::....|..||.|.:|   .|: .|||:
Mouse   697 TYRPEYAVNSIKTDVHSPGNFRIIGTLQNSAEFADAFHCRKNSYMNPE-RKCRV 749

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl8	NP_609795.2	GluZincin	32..618	CDD:472708	164/729 (22%)
Mme	NP_032630.2	Stop-transfer sequence. /evidence=ECO:0000255	16..23
		M13	77..748	CDD:341056	164/729 (22%)