Protein Alignment Nepl8 and nep-10

DIOPT Version :9

• Sequence 1: NP_609795.2
• Gene: Nepl8 / 34983
• FlyBaseID: FBgn0032585
• Length: 619
• Species: Drosophila melanogaster
• Sequence 2: NP_494532.2
• Gene: nep-10 / 173684
• WormBaseID: WBGene00017555
• Length: 711
• Species: Caenorhabditis elegans
• Alignment Length: 709
• Identity: 132/709 - (18%)
• Similarity: 249/709 - (35%)
• Gaps: 192/709 - (27%)

  Fly    20 LLNGILSHVDKEANPCENYYNHACGQYNMRHIDDTFFDIIQMLDHQV---------NQNLVKLMD 75
            |.:.:.::.|...:||:::|.|.||::               .:|..         ...|.||:.
 Worm    85 LAHELHNYKDPSVDPCQDFYQHFCGKF---------------YEHSAIGQGRMATKRSTLSKLIR 134

  Fly    76 ELEMSSQLPDFNVSSVDGKVLRYYLSCRGAPRNMDSLSQYLKVISPGEGL----------TWPQF 130
            |..:.::.   :.|..:..:.:.|..||...:..|     |..|.|...|          .||..
 Worm   135 EFLLKNKT---STSKSENTMKQVYAKCRELQKISD-----LNSIPPQALLDIFSDIKKIGAWPVL 191

  Fly   131 IPDGSSWPQENFKWLKALAHLHRYGLTNV-FFNLEVVSNP-------------RNASEYMVELNT 181
            ..|   |....|...:.|..|...|.|:: ||:.:.::.|             ::..|.:|::..
 Worm   192 DKD---WDGSKFNLNEMLRQLVNLGETHLGFFHFDFIARPYVLIKPPLKQGVQKSVLEKVVKMIL 253

  Fly   182 PT--------FGEESQLPNSFIEILSVLYIIKVP--SSEIITLARKMRTLE---LLLKTMINPID 233
            ..        |.|:.   :.:.|:.:.:.|.|:|  |..|:.|...:|.:.   |:|:.|  |..
 Worm   254 EANEIKMDQGFSEDL---DEYFELSNRIKIDKLPRTSRSIVGLLPDVRRINFRGLILEMM--PRS 313

  Fly   234 TLNNRYISIRDFQMETGHNWQRFFEILIGSSAAPELQVLVRNFRYFTALKELMDKQDARLVASYI 298
            .: ||::.....::.|.|:     .:.:..:....|..::|:             ...|.:|:|:
 Worm   314 KM-NRFLGTLFQKVVTYHH-----PLFVRDNETNHLDTIIRS-------------TSNRALANYL 359

  Fly   299 MTRF---AIFLLDETMGGRESTECVSQV------RRNMNLAANMLYKERFFEDSTFSANILEIKD 354
            :..|   :|..|  |.|.:...|...::      |.::.:         |..:.....|..|:..
 Worm   360 IFNFIHSSIKFL--TFGLKSDRERCEKIVVQELPRPSLRV---------FMRNCVDKGNREEVAK 413

  Fly   355 IFEKLRHQFLLQVDQNHLELTALQMKFFVRKAEAIEINVVNLPKTDDLRHFIGQYYQDLQFPTGE 419
            :.|.::...|..:.::. ..|....|..::|.|||.. ::..|...|....:.:.|::|.....:
 Worm   414 LTETVKENVLEMIRESD-SFTPSVKKRVLKKVEAIGA-IIGYPDHFDPPGTLDKEYENLTLDASD 476

  Fly   420 LDYHQEHLKVLQFRTQKML---------------AQSSKGHSEEQNILTYRSQAAPLPP--PQPF 467
             .|::...|:.|.|.|..:               .:.:..:..:.|.||.      |.|  ..||
 Worm   477 -SYYKMSQKLHQLRLQHQMEFLAGQTPLSPSDQVLEVNAHYDSKDNALTV------LAPFLDDPF 534

  Fly   468 FQLESEDVFKYSLMGYIMAH---HLISA--------FATEGITIGSDGNDQSFRSHRFEEAVSCL 521
            |.....:.......|:::.|   |.|..        :.||.:|             .:.:...||
 Worm   535 FDSTYPEYVNLIFTGFLIGHEFGHSIDPKILRRDGWYKTEDMT-------------EYGKRAQCL 586

  Fly   522 SRNSENID---------------ESMGDIAGLELAYFTYAKM--AKNRNRLDFTHLPPEQIFFLN 569
            ....:|.|               |.:||..|.::.:..:.||  :|.:..:.|.....:|::|..
 Worm   587 IDQYDNYDDPDHGKQMNGTYCIGEIVGDWVGRDVTWRAFKKMDLSKMQKLIGFEDKNLDQLYFRI 651

  Fly   570 VGQFFCGNSDM--LVQYKEDQ-----VRLQRAIEGFEPFDKAFGCYRNKPKH--EKCRL 619
            ...||||...|  |.|...|.     .|:.........|.|||.|....|.:  :||::
 Worm   652 QSLFFCGPRSMKSLEQLLSDPHPTEVFRVNGIYSNMPQFAKAFNCPIGSPMNPEKKCKM 710

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl8	NP_609795.2	GluZincin	32..618	CDD:301352	129/694 (19%)
nep-10	NP_494532.2	M13	97..709	CDD:189000	129/694 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910