Protein Alignment Nepl8 and Ecel1

DIOPT Version :10

• Sequence 1: NP_609795.2
• Gene: Nepl8 / 34983
• FlyBaseID: FBgn0032585
• Length: 619
• Species: Drosophila melanogaster
• Sequence 2: NP_067281.2
• Gene: Ecel1 / 13599
• MGIID: 1343461
• Length: 775
• Species: Mus musculus
• Alignment Length: 733
• Identity: 148/733 - (20%)
• Similarity: 271/733 - (36%)
• Gaps: 216/733 - (29%)

  Fly    26 SHVDKEANPCENYYNHACGQYNMRHI---DDTFFDIIQMLDHQVNQNLVKLMDELEMSSQLPDFN 87
            :::|...:||:::|:.|||.:..||.   |...:..|..:..|..:.|.:|   |...:..|.
Mouse   115 ANLDASIDPCQDFYSFACGGWLRRHAIPDDKLTYGTIAAIGEQNEERLRRL---LARPTGGPG-- 174

  Fly    88 VSSVDGKVLRYYLSC-------RGAPRNMDSLSQYLKVISP--GEGLTWPQFIPDGSSWPQENFK 143
             .:...||..::.||       |..||.|      |:||..  |..|......|..:.|
Mouse   175 -GAAQRKVRAFFRSCLDMREIERLGPRPM------LEVIEDCGGWDLGGAADRPGAARW------ 226

  Fly   144 WLKALAHLHR--YGLTNVF-----FNLEVVSNPRNASEYMVELNTPTFGEESQLPNSFIEILSVL 201
                  .|:|  |....|:     |:|.|..:.||:|.|::.::.    :...||.      ..|
Mouse   227 ------DLNRLLYKAQGVYSAAALFSLTVSLDDRNSSRYVIRIDQ----DGLTLPE------RTL 275

  Fly   202 YIIKVPSSEIITLARKM---RTLELL----LKTMINPIDTLNNRY--ISIRDF-----QMETGHN 252
            |:.:...||.|..|.::   |.|.||    ::.....|..|..|.  ||:.::     .:.:.:|
Mouse   276 YLAQDEESEKILAAYRVFMQRLLRLLGADAVEQKAQEILQLEQRLANISVSEYDDLRRDVSSAYN 340

  Fly   253 ---------------WQRFFEILIGSSAAPELQVLVRNFRYFTALKELMDKQDARLVASYIMTRF 302
                           |:...:.:.....:.|.:|::....|...:.:|:.....|::.:|::.|.
Mouse   341 KVTLGQLQKIIPHLQWKWLLDQIFQEDFSEEEEVVLLATDYMQQVSQLIRSTPRRILHNYLVWRV 405

  Fly   303 AIFL--------------LDETMGGRESTE-----CVSQVRRNMNLAANMLYKERFFEDSTFSAN 348
            .:.|              |.:.|.|.:..:     |:.|..|:..:|...|:....|.    :|:
Mouse   406 VVVLSEHLSSPFREALHELAKEMEGNDKPQELARVCLGQANRHFGMALGALFVHEHFS----AAS 466

  Fly   349 ILEIKDIFEKLRH---QFLLQVDQNHLELTA-----LQMKF-------FVRKAEAIEINVVNLPK 398
            ..:::.:.|.:::   |.|.::|....:..|     ||...       |:.|.||::
Mouse   467 KAKVQQLVEDIKYILGQRLEELDWMDAQTKAAARAKLQYMMVMVGYPDFLLKPEAVD-------- 523

  Fly   399 TDDLRHFIGQYYQDLQFPTGELDYHQEHLKVLQFRTQ---KMLAQSSKGHSEEQNILTYRSQAAP 460
                        ::.:|...|..|.:..|..::|..|   |.:.|..             .:::.
Mouse   524 ------------KEYEFEVHEKTYFKNILNSIRFSIQLSVKKIRQEV-------------DKSSW 563

  Fly   461 LPPPQP----FFQLESEDVF------------------KYSLMGYIMAHHLISAFATEGITIGSD 503
            |.|||.    :...:::.||                  .|..:|.|:.|.|...:...|......
Mouse   564 LLPPQALNAYYLPNKNQMVFPAGILQPTLYDPDFPQSLNYGGIGTIIGHELTHGYDDWGGQYDRS 628

  Fly   504 GN-----DQSFRSHRFEEAVSCLSRNSEN-------------IDESMGDIAGLELAYFTYAKMAK 550
            ||     .::..|| |.....|:.|..:|             :.|::.|:.||:|||:.|.|..:
Mouse   629 GNLLHWWTETSYSH-FLRKAECIVRLYDNFTVYNQRVNGKHTLGENIADMGGLKLAYYAYQKWVR 692

  Fly   551 NR------NRLDFTHLPPEQIFFLNVGQFFC---GNSDMLVQYKEDQ-----VRLQRAIEGFEPF 601
            ..      :||.:||   .|:||:...|.:|   .:..:.:|...|:     .|:..::..||.|
Mouse   693 EHGPEHPLHRLKYTH---NQLFFIAFAQNWCIKRRSQSIYLQVLTDKHAPEHYRVLGSVSQFEEF 754

  Fly   602 DKAFGCYRNKPKH--EKC 617
            .:||.|.::.|.:  .||
Mouse   755 GRAFHCPKDSPMNPVHKC 772

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl8	NP_609795.2	GluZincin	32..618	CDD:472708	147/727 (20%)
Ecel1	NP_067281.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	30..52
		M13	121..773	CDD:341056	147/727 (20%)