Protein Alignment Nepl8 and Nep5

DIOPT Version :10

• Sequence 1: NP_609795.2
• Gene: Nepl8 / 34983
• FlyBaseID: FBgn0032585
• Length: 619
• Species: Drosophila melanogaster
• Sequence 2: XP_061503273.1
• Gene: Nep5 / 1273520
• VectorBaseID: AGAMI1_014349
• Length: 834
• Species: Anopheles gambiae
• Alignment Length: 837
• Identity: 162/837 - (19%)
• Similarity: 283/837 - (33%)
• Gaps: 298/837 - (35%)

  Fly     3 IICLL-LVPLVAASSNTRLLNGILSH-VDKEANPCENYYNHACGQYNMRH-IDDTF--FD----- 57
            |.||| ..|.:..|::.......|.| :|...:|||::|.:|||.:...| ..||:  ||
Mosquito    75 IACLLHFPPEICHSADCLRSAAALKHSMDLTVDPCEDFYQYACGNWEDEHPRPDTYVSFDWFSER 139

  Fly    58 ---IIQMLDHQVNQNLVKLMDELEMSSQLPD-------------FNVSSVD----GKVLRYYLSC 102
               |::.:.|.:..|          ||.|..             .|::::|    |.|.:|.
Mosquito   140 QAKILRNIRHYLQAN----------SSALDPKPVVQARTMYAACLNLTAMDRLGYGPVFKYL--- 191

  Fly   103 RGAPRNMDSLSQYLKVISPGEGLTWPQFIPDGSSWPQENFKWLKALAHLHRYGLTNVFFNLEVVS 167
                 ....|..|..:::..||       |..:::....|.|:|:||.:.:....::|..|:|..
Mosquito   192 -----KQFQLPPYPSLLNVTEG-------PASATFQGYGFDWVKSLAKIKQLLGMDIFIGLDVYP 244

  Fly   168 NPRNASEYMVELNTPTFGEESQLPNSFIEILSVLYIIKVPSSEIITLARKMRTLELL-------- 224
            :||:.....:.|.||..|  |.||.               :::|:...|:.||...|
Mosquito   245 DPRHRDYNRLVLGTPESG--SDLPF---------------NTDILRHIRRGRTRRKLMVSADDEA 292

  Fly   225 -----------------------------LKTMIN------PIDTLN------------------ 236
                                         :|.::|      .:::.|
Mosquito   293 DGESDGEEVEDADDEVGPLTAYKKFMIGVMKLLVNSTDPTIKVESFNAQFERAATIVVQFSDSIS 357

  Fly   237 --NR---------------------YISIRDFQMETGHN---------WQRFFEILIGS--SAAP 267
              ||                     |.::.|.|..|..:         |:|    |:.|  ...|
Mosquito   358 KFNREAENASRSTNVEDRLNLQDIVYYTVADLQNITDTHLAPKDPLPIWER----LLASVFEGIP 418

  Fly   268 ELQVLVRNFRYFTALKELMDKQDARLVASYI----MTRFAIF---------LLDETMGGRE---- 315
            |.|:.:::....|:..:|:   ..:|:..|:    :....::         :|..|:..|:
Mosquito   419 EAQLNLQDELILTSNADLL---YLKLLVDYLAVTPLAHIELYIWWTVVEELILHTTLEVRKLYYD 480

  Fly   316 --------------STECVSQVRRNMNLAAN-MLYKERFFEDSTFSANILEIKDIFEKLRHQFL- 364
                          :..|...|.|.:.:|.: .:..:.|..|:.     ..::|:...:|..|.
Mosquito   481 YYKSIAPSDGFSSRTLYCTGTVNRLLGMAVSYAISSDNFTRDTK-----PRVQDMLRYIRTAFEG 540

  Fly   365 LQVDQNHLELTALQMKFFVRKAEAIEINVVNLPKTDDLRHFIGQYYQDLQFPTGELDYH--QEHL 427
            |..|...::....|..  :||::|             :|..||       ||...||:.  ::|.
Mosquito   541 LVRDTTWMDWPTKQST--LRKSQA-------------MRSLIG-------FPDWILDHRELEQHY 583

  Fly   428 KVLQFRTQKMLAQSSKGHSEEQNIL------------------------TYRSQAAPLP---PPQ 465
            ..||......| ::.....:.:||:                        |::..|..:|   ...
Mosquito   584 SGLQVNESTHL-ENMMQEVQRKNIIKLRRWRQKHELSWETLPTNVNAFHTFQENAITIPIAILQY 647

  Fly   466 PFFQLESEDVFKYSLMGYIMAHHLISAFATEGITIGSDGN------DQSFRSH--RFEEAVSCLS 522
            ||:.|..| ...|..:|.|:.|.|...|...|.....|||      |::.:.:  |.:..||..|
Mosquito   648 PFYHLGLE-ALNYGALGTILGHELTHGFDDSGRQFDKDGNLAQWWTDRTVQEYVNRTKCFVSQYS 711

  Fly   523 R-----NSENID------ESMGDIAGLELAYFTYAKMAKNRNR----LDFTHLPPEQIFFLNVGQ 572
            |     ..:.||      |::.|..|:..|:..|....||..:    ..|.|...||:||::.|.
Mosquito   712 RYYIPEADDYIDGLLTLGENIADNGGVREAFRAYQLYVKNGGKDPLLPGFEHYTHEQLFFISYGN 776

  Fly   573 FFCGNSDMLV--QYKED-----QVRLQRAIEGFEPFDKAFGC---YRNKPKHEKCRL 619
            .:|.:.....  .|.:|     :.||:..:.....|.:.|||   ....|..:|||:
Mosquito   777 IWCESHTQAAAKAYLDDSHCPGKFRLKGVLTNSPEFSQTFGCKPGTEMNPGKDKCRI 833

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl8	NP_609795.2	GluZincin	32..618	CDD:472708	151/803 (19%)
Nep5	XP_061503273.1	None