DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl8 and EEF1AKMT4-ECE2

DIOPT Version :9

Sequence 1:	NP_609795.2	Gene:	Nepl8 / 34983	FlyBaseID:	FBgn0032585	Length:	619	Species:	Drosophila melanogaster
Sequence 2:	NP_055508.3	Gene:	EEF1AKMT4-ECE2 / 110599583	HGNCID:	53615	Length:	883	Species:	Homo sapiens

Alignment Length:	739	Identity:	162/739 - (21%)
Similarity:	291/739 - (39%)	Gaps:	182/739 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 IICLLLVPLVA--------ASSNT-------RLLNGILSHVDKEANPCENYYNHACGQYNMRH-I 51
            :..|||..|||        .|.:|       |:...||..:|:..:|||::|..:||.:..|: :
Human   188 LAALLLGCLVALGVQYHRDPSHSTCLTEACIRVAGKILESLDRGVSPCEDFYQFSCGGWIRRNPL 252

  Fly    52 DD------TFFDIIQMLDHQVNQNLVKLMDELEMSSQLPDFNVSS-VDGKVLRYYLSCRGAPRNM 109
            .|      ||..:...     ||.::|.:  ||.::    ||.|| .:.|..|:||||....|..
Human   253 PDGRSRWNTFNSLWDQ-----NQAILKHL--LENTT----FNSSSEAEQKTQRFYLSCLQVERIE 306

  Fly   110 DSLSQYLKVISP---GEGLTWPQFIPDGSSWPQENF-KWLKALAHLHRYGLTNVFFNLEVVSNPR 170
            :..:|.|:.:..   |..:|.|        |.|:|| :.|||:|..:|   ...||.:.:.::.:
Human   307 ELGAQPLRDLIEKIGGWNITGP--------WDQDNFMEVLKAVAGTYR---ATPFFTVYISADSK 360

  Fly   171 NASEYMVELNTPTFGEESQLPNSFIEILSVLYIIKVPSSEIITL--------------------- 214
            :::..::::      ::|.|   |:.... .|:.:..:.:::|.
Human   361 SSNSNVIQV------DQSGL---FLPSRD-YYLNRTANEKVLTAYLDYMEELGMLLGGRPTSTRE 415

  Fly   215 -ARKMRTLELLLKTMINPIDTLNN-----RYISIRDFQ-METGHNWQRFFEILIG----SSAAPE 268
             .:::..||:.|..:..|.|...:     ..:||.:.| :....:|..|...|:.    |.:.|
Human   416 QMQQVLELEIQLANITVPQDQRRDEEKIYHKMSISELQALAPSMDWLEFLSFLLSPLELSDSEP- 479

  Fly   269 LQVLVRNFRYFTALKELMDKQDARLVASYIM------------TRFAIF---LLDETMGGRES-- 316
              |:|....|...:.||:::.:..::.:|::            .||...   ||:...|.::|
Human   480 --VVVYGMDYLQQVSELINRTEPSILNNYLIWNLVQKTTSSLDRRFESAQEKLLETLYGTKKSCV 542

  Fly   317 ---TECVSQVRRNMNLAANMLYKERFFEDST---FSANILEIKDIFEKLRHQFLLQVDQNHLELT 375
               ..|:|.....:..|...|:.:..|:..:   ....|.||:..||:...| |:.:|    |.|
Human   543 PRWQTCISNTDDALGFALGSLFVKATFDRQSKEIAEGMISEIRTAFEEALGQ-LVWMD----EKT 602

  Fly   376 ALQMKFFVRKAEAIEINVVNLP-------KTDDLRHFIGQYYQDLQFPTGELDYHQEHLKVLQFR 433
            ....|   .||:|| .:::..|       :.||:       |..  :...|..:.|..|.:..|.
Human   603 RQAAK---EKADAI-YDMIGFPDFILEPKELDDV-------YDG--YEISEDSFFQNMLNLYNFS 654

  Fly   434 TQKMLAQSSKGHSEEQNILTYRSQAAPLPPPQ------------PFFQLESEDVFKYSLMGYIMA 486
            .:.|..|..|..|.:|..:|.::..|...|.:            ||:.........:..:|.:|.
Human   655 AKVMADQLRKPPSRDQWSMTPQTVNAYYLPTKNEIVFPAGILQAPFYARNHPKALNFGGIGVVMG 719

  Fly   487 HHLISAFATEGITIGSDGNDQ---------SFRSHR--FEEAVSCLSRNSENID------ESMGD 534
            |.|..||..:|.....:||.:         :||:|.  .||..:....|.|.::      |::.|
Human   720 HELTHAFDDQGREYDKEGNLRPWWQNESLAAFRNHTACMEEQYNQYQVNGERLNGRQTLGENIAD 784

  Fly   535 IAGLELAYFTY-AKMAKN--RNRLDFTHLPPEQIFFLNVGQFFC------GNSDMLV--QYKEDQ 588
            ..||:.||..| |.:.|:  ..:|....|...|:||:...|.:|      .:.:.||  .:...:
Human   785 NGGLKAAYNAYKAWLRKHGEEQQLPAVGLTNHQLFFVGFAQVWCSVRTPESSHEGLVTDPHSPAR 849

  Fly   589 VRLQRAIEGFEPFDKAFGCYRNKP 612
            .|:...:.....|.:.|||....|
Human   850 FRVLGTLSNSRDFLRHFGCPVGSP 873

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl8	NP_609795.2	GluZincin	32..618	CDD:301352	150/695 (22%)
EEF1AKMT4-ECE2	NP_055508.3	Methyltransferase-like region. /evidence=ECO:0000305	1..160
		Methyltransf_25	62..>128	CDD:316196
		S-adenosyl-L-methionine binding. /evidence=ECO:0000250\|UniProtKB:P0DPD7	88..89
		S-adenosyl-L-methionine binding. /evidence=ECO:0000250\|UniProtKB:P0DPD7	113..114
		M13	232..881	CDD:189000	150/695 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910