Protein Alignment Nepl8 and Ece2

DIOPT Version :9

• Sequence 1: NP_609795.2
• Gene: Nepl8 / 34983
• FlyBaseID: FBgn0032585
• Length: 619
• Species: Drosophila melanogaster
• Sequence 2: NP_647454.2
• Gene: Ece2 / 107522
• MGIID: 1101356
• Length: 763
• Species: Mus musculus
• Alignment Length: 717
• Identity: 149/717 - (20%)
• Similarity: 262/717 - (36%)
• Gaps: 185/717 - (25%)

  Fly    19 RLLNGILSHVDKEANPCENYYNHACGQY-------NMRHIDDTFFDIIQMLDHQVNQNLVKLMDE 76
            |:...||..:|:..:||:::|..:||.:       |.|...:||..:...     ||.::|.:
Mouse    99 RVAGKILESLDRGVSPCQDFYQFSCGGWIRRNPLPNGRSRWNTFNSLWDQ-----NQAILKHL-- 156

  Fly    77 LEMSSQLPDFNVSS-VDGKVLRYYLSCRGAPR----NMDSLSQYLKVISPGEGLTWPQFIPDGSS 136
            ||.::    ||.|| .:.|...:||||..:.|    ....|...:..|. |..:|.|
Mouse   157 LENTT----FNSSSEAERKTRSFYLSCLQSERIEKLGAKPLRDLIDKIG-GWNITGP-------- 208

  Fly   137 WPQENF-KWLKALAHLHRYGLTNVFFNLEVVSNPRNAS--------------------------- 173
            |.:::| ..|||:|..:|   ...||.:.|.::.::::
Mouse   209 WDEDSFMDVLKAVAGTYR---ATPFFTVYVSADSKSSNSNIIQVDQSGLFLPSRDYYLNRTANEK 270

  Fly   174 ------EYMVELNTPTFGEESQLPNSFIEILSVLYIIKVPSSEIITLARKMRTLELLLKTMINPI 232
                  :|||||.....|:.:.......::|.                     ||:.|..:..|.
Mouse   271 VLTAYLDYMVELGVLLGGQPTSTREQMQQVLE---------------------LEIQLANITVPQ 314

  Fly   233 DTLNN-----RYISIRDFQ-METGHNWQRFFEILIGSSAAPELQ-VLVRNFRYFTALKELMDKQD 290
            |...:     ..:||.:.| :....:|..|...|:......:.: |:|....|...:.||:::.:
Mouse   315 DQRRDEEKIYHKMSISELQALAPAVDWLEFLSFLLSPLELGDSEPVVVYGTEYLQQVSELINRTE 379

  Fly   291 ARLVASYIM------------TRFAIF---LLDETMGGRES-----TECVSQVRRNMNLAANMLY 335
            ..::.:|::            .||...   ||:...|.::|     ..|:|.....:..|...|:
Mouse   380 PSILNNYLIWNLVQKTTSSLDQRFETAQEKLLETLYGTKKSCTPRWQTCISNTDDALGFALGSLF 444

  Fly   336 KERFFEDST---FSANILEIKDIFEKLRHQFLLQVDQNHLELTALQMKFFVRKAEAIEINVVNLP 397
            .:..|:..:   ....|.||:..||:.... |:.:|    |.|.|..|   .||:|| .:::..|
Mouse   445 VKATFDRQSKEIAEGMINEIRSAFEETLGD-LVWMD----EKTRLAAK---EKADAI-YDMIGFP 500

  Fly   398 -------KTDDLRHFIGQYYQDLQFPTGELDYHQEHLKVLQFRTQKMLAQSSKGHSEEQNILTYR 455
                   :.||:       |..  :...|..:.|..|.:..|..:.|..|..|..|.:|..:|.:
Mouse   501 DFILEPKELDDV-------YDG--YEVSEDSFFQNMLNLYNFSAKVMADQLRKPPSRDQWSMTPQ 556

  Fly   456 SQAAPLPPPQ------------PFFQLESEDVFKYSLMGYIMAHHLISAFATEGITIGSDGNDQ- 507
            :..|...|.:            ||:.........:..:|.:|.|.|..||..:|.....:||.:
Mouse   557 TVNAYYLPTKNEIVFPAGILQAPFYAHNHPKALNFGGIGVVMGHELTHAFDDQGREYDKEGNLRP 621

  Fly   508 --------SFRSHR--FEEAVSCLSRNSENID------ESMGDIAGLELAYFTYAKMAKNRNR-- 554
                    :|::|.  .||..|....|.|.::      |::.|..||:.||..|....:....
Mouse   622 WWQNESLTAFQNHTACMEEQYSQYQVNGERLNGLQTLGENIADNGGLKAAYNAYKAWLRKHGEEQ 686

  Fly   555 -LDFTHLPPEQIFFLNVGQFFC------GNSDMLV--QYKEDQVRLQRAIEGFEPFDKAFGCYRN 610
             |....|...|:||:...|.:|      .:.:.||  .:...:.|:...:.....|.:.|||...
Mouse   687 PLPAVGLTNHQLFFVGFAQVWCSVRTPESSHEGLVTDPHSPARFRVLGTLSNSRDFLRHFGCPVG 751

  Fly   611 KP 612
            .|
Mouse   752 SP 753

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl8	NP_609795.2	GluZincin	32..618	CDD:301352	145/704 (21%)
Ece2	NP_647454.2	M13	112..761	CDD:189000	145/704 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010