DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nepl8 and kel

DIOPT Version :9

Sequence 1:	NP_609795.2	Gene:	Nepl8 / 34983	FlyBaseID:	FBgn0032585	Length:	619	Species:	Drosophila melanogaster
Sequence 2:	XP_005157998.1	Gene:	kel / 101882278	ZFINID:	ZDB-GENE-110411-118	Length:	759	Species:	Danio rerio

Alignment Length:	768	Identity:	143/768 - (18%)
Similarity:	244/768 - (31%)	Gaps:	247/768 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 IIC-------LLLVPLVAASSNTRLLNGILSHVDKEAN--------------------------- 33
            ::|       |||.|...:...|.|..||.||:.|.|:
Zfish    28 VLCNKYKYRRLLLPPFAVSLFATALGLGIYSHLQKTADPWKSKWKSAAPLCLSPACIRASEHFSV 92

  Fly    34 -------PCENYYNHAC---------------GQYNMRHIDDTFFDIIQM---------LDHQVN 67
                   ||: |:..||               |:.| :|.:.....:|:|         .|.|:.
Zfish    93 AMDPFSRPCD-YFLFACGAGGSSTNRDRQRVKGEVN-KHSEVRTRGLIEMRRGTDGWSKSDGQLK 155

  Fly    68 ---QNLVKLMDELEMSSQLPDFNVS--SVDGKVLRYYLSCRGA-PRNMDSLSQYLKVISPGEGLT 126
               .....|:..::...:.||..||  :.:.|...::.||..| .|.......:|.::....|
Zfish   156 TFPDRQTALLTAIKEILEAPDEAVSMGAAEQKAKNFFKSCMNAESREKMGSEPFLTLLQQLGG-- 218

  Fly   127 WPQFIPDGSSWPQENFKWLKALAHLHRYGLTNVFFNLEVVSNPRN----ASEYMVELNTPTF--- 184
            |..    ...|.|.:|....||. :.:|. |..|||:.|...|..    ::.:.::::.|.|
Zfish   219 WAV----SGVWNQTDFNSTLALL-MGQYS-TFPFFNVYVGPEPSEEQSASNRHYIQIDEPHFQFP 277

  Fly   185 ---GEESQLPNSFIEILSVLY--------IIKVPSSE----------------IIT------LAR 216
               ..::|...:....|...|        ::.|||..                :.|      |::
Zfish   278 IEWNSKTQKAKANTRYLRPFYSACGQYLVLLGVPSDRTTQHCGLFVSLSTTLAVATFPLPYRLSQ 342

  Fly   217 KM---RTLELLLKTMINPID-------TLNNRYISIRDFQM-----------ETGHNWQRFFEIL 260
            |:   ||....|:|:...:|       |.....||..|..:           :|.|.||...|::
Zfish   343 KLLYRRTTIQELQTLAPAVDWLACLQATFQPLLISKSDIVLVHNLPYIIHMSKTIHLWQVQHELM 407

  Fly   261 IGSSAAPELQVLVRNFRYFTALKELMDKQDARLVASYIMTRFAIFLLDETMGGRESTECVSQVRR 325
               ...|     :..:..|:.|:.|:...|:|..  .||..::| ...:|........||.|..|
Zfish   408 ---GTGP-----LNTYMIFSLLQTLIPALDSRFF--QIMRNYSI-ATGDTQEMPHWWRCVQQTER 461

  Fly   326 NMNLAANMLYKERFFEDSTFSANILEIKDIFEKLRHQFLLQVDQNHLELTALQMK------FFVR 384
            ..:...:...:|:..:......    |:|::..|:.           :||.|..:      |.:.
Zfish   462 GFDTLLSHAIREKHAQKEAEEL----IQDVYSSLKK-----------KLTDLSWRDEKESDFILN 511

  Fly   385 KAEA----IEINVVNLPKTDDLRHFIGQYYQDLQFPTGELDYHQEHLKVLQFRTQKMLAQSSKGH 445
            |..:    |..|..||..| :|.|.    |:.:..  .|.|:...:|::|....:......|.|.
Zfish   512 KINSLNPRISTNTNNLSYT-ELNHL----YEKVIL--NEEDFFSNYLQILLLEQKSRARLLSLGT 569

  Fly   446 SEEQNILTYRSQAAPLPPP-----QPFFQLESEDVFKYSLMGYIMAHHLISAFATEGITIGSDGN 505
            ..|...:|.......:..|     .|||.........|..:|.:||..|:.....:..|...:..
Zfish   570 QTEGLSMTPFISGNDIIVPVGMFVSPFFHSSYPRALNYGTLGSLMAKDLLHLLLPDIYTKAKNPE 634

  Fly   506 DQSFRSHRFEEAVSCLSRNSENIDESMG-----------------DIAGLELAYFTYAKMAKNRN 553
            .:|.          |:..:..::.:..|                 ..:.|::|...| ||:..|.
Zfish   635 TESL----------CVWSHYLSVTKGPGWGDAFYLPSSKQQEVWVQYSALQVALDAY-KMSFKRY 688

  Fly   554 RLD-------FTHL-------------------PPEQIFFLNVGQFFCGNSDM 580
            ..|       :.||                   |.|..|.:.|   .|.||.:
Zfish   689 LADSSLPGFSYVHLFLSSFTKVTCDTDAYREFMPLEPSFLVTV---LCSNSGL 738

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl8	NP_609795.2	GluZincin	32..618	CDD:301352	131/732 (18%)
kel	XP_005157998.1	GluZincin	99..>620	CDD:301352	110/563 (20%)
kel	XP_005157998.1	GluZincin	583..>721	CDD:301352	22/148 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100