Protein Alignment Nepl8 and ecel1

DIOPT Version :10

• Sequence 1: NP_609795.2
• Gene: Nepl8 / 34983
• FlyBaseID: FBgn0032585
• Length: 619
• Species: Drosophila melanogaster
• Sequence 2: XP_012818808.2
• Gene: ecel1 / 100496473
• XenbaseID: XB-GENE-989944
• Length: 764
• Species: Xenopus tropicalis
• Alignment Length: 741
• Identity: 154/741 - (20%)
• Similarity: 293/741 - (39%)
• Gaps: 180/741 - (24%)

  Fly     5 CLLLVPLVAASSNTRLLNG-------------ILSHVDKEANPCENYYNHACGQYNMRH---IDD 53
            |:|::..::...:.:.|.|             |.:::|...:||.::|:.|||.:..||   .|.
 Frog    73 CMLVLKYLSMEQDVQCLEGCQERKAFMRASKFITNNIDPTISPCTDFYSFACGGWLRRHGIPEDK 137

  Fly    54 TFFDIIQMLDHQVNQNLVKLMDELEMSSQLPDFNVSSVDGKVLRYYLSCRGAPRNMDSLS--QYL 116
            ..:..|..:..|..:.|..|     :...:...:..|.:.||..::.||... |::|.|.  ..|
 Frog   138 LIYGTIAAIGEQNEEKLEHL-----LLQPVRRKHKGSAERKVKEFFKSCLNM-RDIDRLGARPML 196

  Fly   117 KVISPGEGLTWPQFIPDGSSWPQENFKWLKALAHLHRYGLTNVFFNLEVVSNPRNASEYMVELNT 181
            :||....|  |.  :|:.   |:..:.:.:.|........|.|||::.|..:.:|:|.|::.::.
 Frog   197 QVIEDCGG--WD--LPED---PRTQWDFNELLYKTQGVYSTAVFFSMTVSLDDKNSSRYIIRIDQ 254

  Fly   182 P--TFGEESQLPNSFIEILSVLYIIKVPSSEIITL---------ARKMRTLELLLKT-------- 227
            .  |..|.:.......|.:.||...||....|::|         |.::..||..|..
 Frog   255 DGLTLPERTLYLGQDEESIKVLEAYKVFMQTILSLLGVENVQKKAEEILHLEQHLSNITISEFDD 319

  Fly   228 MINPIDTLNNRYISIRDFQMETGH-NWQRFFEILIGSSAAPELQVLVRNFRYFTALKELMDKQDA 291
            |...|.|:.|: :::...|..|.| ||:.....:..::...:.:|:|....|...:.|::....|
 Frog   320 MRRDISTMYNK-VTLAQLQQITPHLNWKNLLNRIFHTNFPEDEEVVVLATDYMQKVSEMIRSTPA 383

  Fly   292 RLVASYIMTRFAIFL--------------LDETMGGRE-----STECVSQVRRNMNLAANMLYKE 337
            .::.:|::.|..:.|              |.:.|.|.|     :..|::|..::..:|...|:.|
 Frog   384 SVLHNYMLWRIVVVLSEHLSTPFRDAIHELSKEMEGSEKQAELTKVCLTQANKHFGMALGALFVE 448

  Fly   338 RFFEDSTFSANILEIKDIFEKLRHQFLLQVDQNHLELTALQMKFFVRKAEAIEINVVNLPKTDDL 402
            .:|..|:.:    :::.:.|.::|  :|......|:....:.|...|               :.|
 Frog   449 EYFSSSSKA----KVQQLVENIKH--ILDYRLEELDWMDTETKQAAR---------------EKL 492

  Fly   403 RH---FIGQYYQDL-----------QFPTGELDYHQEHLKVLQFRTQKMLAQSSKGHSEEQNILT 453
            :|   .||  |.|:           :|...|..|.:..|..::: :.||..:..:     |.:
 Frog   493 KHMMVMIG--YPDVLLQPESMDKEYEFEVNEKTYFKNILNSIRY-SIKMAVRRIR-----QEV-- 547

  Fly   454 YRSQAAPLPPPQP----FFQLESEDVF------------------KYSLMGYIMAHHLISAFATE 496
              .::|.|.|||.    :...:::.||                  .|..:|.|:.|.|...:...
 Frog   548 --DKSAWLLPPQALNAYYLPNKNQMVFPAGILQPTLYDPDFPQSLNYGGIGTIIGHELTHGYDDW 610

  Fly   497 GITIGSDGN------DQSFRSHRFEEAVSCLSRNSEN-------------IDESMGDIAGLELAY 542
            |....::||      :.|:  .:|.:...|:....||             :.|::.|:.||:|||
 Frog   611 GGQYDANGNPIQWWTEDSY--SKFLKKAECIVDLYENFTVYNQRVNGRTTLGENIADLGGLKLAY 673

  Fly   543 FTYAKMAKNRN------RLDFTHLPPEQIFFLNVGQFFC---GNSDMLVQYKEDQ-----VRLQR 593
            :.|.|..::..      ||.:||   :|:||:...|.:|   .:..:.:|...|:     .|:..
 Frog   674 YAYQKWVRDNGPERPLPRLKYTH---DQLFFIAFAQNWCIKRRSQSIYLQVLTDKHAPEHYRVMG 735

  Fly   594 AIEGFEPFDKAFGCYRNKPKH--EKC 617
            ::..||.|.:.|.|.||.|.:  .||
 Frog   736 SVSQFEEFGRVFHCPRNSPMNPVHKC 761

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl8	NP_609795.2	GluZincin	32..618	CDD:472708	148/701 (21%)
ecel1	XP_012818808.2	M13	113..762	CDD:341056	148/701 (21%)