Protein Alignment dac and Dach2

DIOPT Version :10

• Sequence 1: NP_723971.1
• Gene: dac / 34982
• FlyBaseID: FBgn0005677
• Length: 1081
• Species: Drosophila melanogaster
• Sequence 2: XP_030107383.1
• Gene: Dach2 / 93837
• MGIID: 1890446
• Length: 674
• Species: Mus musculus
• Alignment Length: 803
• Identity: 228/803 - (28%)
• Similarity: 315/803 - (39%)
• Gaps: 313/803 - (38%)

  Fly   141 LSPPP--HGMPSGNGLPTGL------------PPRMPHGLPPHSLGLLNSLQMMHHASPLELMAA 191
            :|.||  ....|..|:|.||            |||    |.|:   ::||....:|..     :.
Mouse     3 VSAPPVISATSSSAGVPGGLFRAEPLYSSPGEPPR----LTPN---MINSFMANNHNG-----SV 55

  Fly   192 AHHHVPPRSYNSPPPISTSDPSANECKLVEYRGQKVAAFIISNETMLCLPQAFELFLKHLVGGLH 256
            ....:...|..|      |:.:.|||::|:..|.|||:|::..:.::||||.|:|||||||||||
Mouse    56 LGGGIGGGSGGS------SNTNTNECRMVDMHGVKVASFLMDGQELICLPQVFDLFLKHLVGGLH 114

  Fly   257 TVYTKLKRLDIVPLVCNVEQVRILRGLGAIQPGVNRCKLLCCKDFDILYRDCTTARCLSIKPPES 321
            |||||||||||.|:||.||||||||||||||||||||||:..|||:.|:.|||.||   .|...:
Mouse   115 TVYTKLKRLDISPVVCTVEQVRILRGLGAIQPGVNRCKLITRKDFETLFTDCTNAR---RKRQMT 176

  Fly   322 NSLQFRSSRPGRPPKRG-------------------------PVGLSLPPTHLSQHPQLKKHRL- 360
            ......||||||||||.                         |.|::  ...:::..:|:|.:|
Mouse   177 RKQAVNSSRPGRPPKRSLGVLQDNARLLPHAVPGLLSPGLITPTGIT--AAAMAEAMKLQKMKLM 239

  Fly   361 ------DNGDYAYENGHISD-------------------MKSPLLANG----------------- 383
                  .||.   :||..|:                   ::|||.|:|
Mouse   240 AMNTLQGNGS---QNGTESEPDDLNSTTGGSESSWDKDKIQSPLAASGPQHGIAHAALAGQPGLG 301

  Fly   384 ----YNPPPINH-------MAFMQMNAHHPGAAALMSPGMPPHGLHARPESQMLKAAAQNAGMSA 437
                .||...||       :.||.|  .||    |:...:||..: |...:||      |...:.
Mouse   302 GAPTLNPLQQNHLLSNRLDLPFMMM--PHP----LLPVSLPPASV-AMAMNQM------NHLNTI 353

  Fly   438 ANMDALARSGIWENCRAAYEDIVKHLERLREERTDERQQAMGVGGAVVDRVGNVMVAEHKPRDLS 502
            |||.|.|:.               |                    :.:.|.|..::.|..|.
Mouse   354 ANMAAAAQI---------------H--------------------SPLSRAGASVIKERIPE--- 380

  Fly   503 SRNCSPTRQSPVLNLSKS---GGNTDHGGSNCDAGSERSDCHSVAGSPARGGSRSLDEGSRSGVG 564
                ||   ||..:|.:|   |..|....|:           ||:.||::
Mouse   381 ----SP---SPAPSLEESHRPGSQTSSHPSS-----------SVSSSPSQ--------------- 412

  Fly   565 GGVASHVGGGIIGVEDDEEEEENLSDENQSE--VDERCLAKDDEDLSDTERDNLSTGSAAAAAAA 627
                          .|...|...:...|:.|  ||:    .:.:.:...:|||...
Mouse   413 --------------MDHHSERMVMMPNNREELIVDQ----DNGQSIKKFQRDNKDI--------- 450

  Fly   628 AAAAAHQLHQHAASHHHQTVGLSHLGVVPPHQRGSPSSAEAAAAALQHQRALNYSQLAAAAAVAN 692
                  ||.|    ||.....|..:.:.|..::           :|.||:.:. :|:
Mouse   451 ------QLSQ----HHLLNTFLHWIELAPLSKK-----------SLHHQKEVP-AQI-------- 485

  Fly   693 GAAVGGGAVANGPTGGGGALTPNEALLAANDAAALAGGLALGPLGIDAHAAVPA--------SST 749
                   .|...|.                |...||.|.||       |...|.        ||.
Mouse   486 -------PVMKSPL----------------DKIQLAPGQAL-------HPGFPGPFIFADSLSSV 520

  Fly   750 ETLLRNIQ----------SLLKVAADNARQQERQISYEKAELKMDVLREREVKDSLERQLVDERK 804
            ||||.|||          .|||||.||||.||:||..||.||::::.||||::::|||||..|.:
Mouse   521 ETLLTNIQVNNISINKINGLLKVALDNARIQEKQIQQEKKELRIELFREREIRENLERQLAVELQ 585

  Fly   805 LRVLYQKRFRRERKIRIRYQQQL 827
            .|...|||.::|:|.:.:.|:.|
Mouse   586 SRSTMQKRLKKEKKAKRKLQEAL 608

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dac	NP_723971.1	DHD_Dac	215..309	CDD:410784	66/93 (71%)
Dach2	XP_030107383.1	DHD_Dac	73..167	CDD:410784	66/93 (71%)