DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dac and dachd

DIOPT Version :9

Sequence 1:	NP_723971.1	Gene:	dac / 34982	FlyBaseID:	FBgn0005677	Length:	1081	Species:	Drosophila melanogaster
Sequence 2:	NP_001074142.1	Gene:	dachd / 791191	ZFINID:	ZDB-GENE-070427-2	Length:	611	Species:	Danio rerio

Alignment Length:	770	Identity:	224/770 - (29%)
Similarity:	301/770 - (39%)	Gaps:	273/770 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    86 SSHTGRGSSCSPASSPSRHPSAVSPVSSLNHSMMQQMQQQQQQQQQQQQQQQHHQLSPPPHGMPS 150
            |:.:...||||..::.|..|||.|...|         |...|...:......:...|.|..|.|
Zfish    24 SASSASSSSCSATAASSSSPSATSASPS---------QSATQNLFRADLISTNCTSSIPLAGKP- 78

  Fly   151 GNGLPTGLPPRMPHGLPPHSLGLLNSLQMMHHASPLELMAAAHHHVPPRSYNSPPPISTSDPSAN 215
                                                             .|::|.|:..: |..|
Zfish    79 -------------------------------------------------VYSTPSPVENT-PQNN 93

  Fly   216 ECKLVEYRGQKVAAFIISNETMLCLPQAFELFLKHLVGGLHTVYTKLKRLDIVPLVCNVEQVRIL 280
            ||::||.||.|||:|.:..:.::||||||:||||||||||||||||||||:|.|:||||||||||
Zfish    94 ECRMVELRGAKVASFTVDGQELICLPQAFDLFLKHLVGGLHTVYTKLKRLEITPVVCNVEQVRIL 158

  Fly   281 RGLGAIQPGVNRCKLLCCKDFDILYRDCTTARCLSIKPPESNSLQFRSSRPGRPPKRGPVGLSLP 345
            |||||||||||||||:..|||:.||.|||.|                ||||||||||
Zfish   159 RGLGAIQPGVNRCKLISRKDFETLYNDCTNA----------------SSRPGRPPKR-------- 199

  Fly   346 PTHLSQHPQLKKHRLDNGDYAYENGHISDMKSPLLANGYNPPPINHMAFMQMNAHHPGAAALMSP 410
             |.....|              ||.||.....|                           .||||
Zfish   200 -TQSVTSP--------------ENPHIMPHTVP---------------------------GLMSP 222

  Fly   411 G-MPPHGLHARPESQMLKAAAQNAGMSAANMDALARSGIWENCRAAYEDIVKHLERLREERTDER 474
            | :||.||.|       .|||..|..:||..:|:....|.....::|.....|      ...|..
Zfish   223 GIIPPTGLTA-------AAAAAAAATNAAIAEAMKVKKIKLEVMSSYHGSNTH------NGPDSE 274

  Fly   475 QQAMGVGGAVVDRVG---NVMVAEHKPRDLSSRNCSPTRQSPVLNLSKSGGNTDHGGSNCDAGS- 535
                  .|.:...||   ..|:..|....:|....|.|.....:|...:..|.........|.|
Zfish   275 ------NGDLSSSVGLELPFMMMPHPLIPVSLPPASVTMAMSQMNHLSTIANMAAAAQGQSAPSR 333

  Fly   536 -------ERSDCHSVAGSPARGGSRSLDEGSRSGVGGGVASHVGGGIIGVEDDEEEEENLSDENQ 593
                   ||     |..||:  .:.||::|.|.|                       ...|.:..
Zfish   334 MVTSVIKER-----VPDSPS--PAPSLEDGRRPG-----------------------SRPSSQRS 368

  Fly   594 SEVDERCLAKDDEDLSDTERDNLSTGSAAAAAAAAAAAAHQLHQHAASHHHQTVGLSHLGVVPPH 658
            |.|                       |::.|...:::....:||:..|.:|..:|||. .::|
Zfish   369 SSV-----------------------SSSPAHTESSSDRMPVHQNGLSMNHALLGLSP-SILP-- 407

  Fly   659 QRGSPSSAEAAAAALQHQRAL----------------NYSQLAAAAAVANGAAVGGGAVANGPTG 707
               .|...:.|...:.:.:.:                :|.:|:.|                |.|.
Zfish   408 ---GPKEGDLAHDIVHNAKRMHLEKEETPMCTPTARDSYERLSLA----------------GQTL 453

  Fly   708 GGGALTPNEALLAANDAAALAGGLALGPLGIDAHAAVPASSTETLLRNIQSLLKVAADNARQQER 772
            ..|:.:|                 .|.|.|:        ||.||||.|||.|||||.||||.||:
Zfish   454 PPGSPSP-----------------FLFPDGL--------SSIETLLTNIQGLLKVAIDNARAQEK 493

  Fly   773 QISYEKAELKMDVLREREVKDSLERQLVDERKLRVLYQKRFRRERKIRIRYQQQL 827
            |:..||.||||::.||||::::||:||..|:|.|.:.|||.::|:|.:.:.|:.|
Zfish   494 QVQLEKTELKMELFRERELRETLEKQLAVEQKNRAIIQKRLKKEKKAKRKLQEAL 548

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dac	NP_723971.1	Ski_Sno	209..310	CDD:280577	72/100 (72%)
dachd	NP_001074142.1	Ski_Sno	88..188	CDD:280577	72/100 (72%)
dachd	NP_001074142.1	GBP_C	<478..531	CDD:303769	30/52 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594420
Domainoid	1	1.000	162	1.000	Domainoid score	I3949
eggNOG	1	0.900	-	-		E1_KOG3915
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2929
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206899at33208
OrthoFinder	1	1.000	-	-		FOG0002588
OrthoInspector	1	1.000	-	-		otm24380
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12577
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4062
SonicParanoid	1	1.000	-	-		X1700
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.980