DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dac and SKIDA1

DIOPT Version :9

Sequence 1:	NP_723971.1	Gene:	dac / 34982	FlyBaseID:	FBgn0005677	Length:	1081	Species:	Drosophila melanogaster
Sequence 2:	NP_997254.3	Gene:	SKIDA1 / 387640	HGNCID:	32697	Length:	908	Species:	Homo sapiens

Alignment Length:	1095	Identity:	209/1095 - (19%)
Similarity:	316/1095 - (28%)	Gaps:	445/1095 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly   221 EYRGQKVAAFIISNETMLCLPQAFELFLKHLVGGLHTVYTKLKRLDIVPLVCNVEQVRILRGLGA 285
            |..|.::...||..:.|..|.|.|...||::  ...||:.::..|.:....|::|::|.|:.:.:
Human    10 EVDGVRLGYLIIKGKQMFALSQVFTDLLKNI--PRTTVHKRMDHLKVKKHHCDLEELRKLKAINS 72

  Fly   286 IQPGVNRCKLLCCKDFDILYRDCTTARCLSIK-------------PPESNSLQFRSSRPG----- 332
            |.....:|.|:..:|.:.||..|.|.|.|..|             |||..:.  .|.|||
Human    73 IAFHAAKCTLISREDVEALYTSCKTERVLKTKRRRVGRALATKAPPPERAAA--ASPRPGFWKDK 135

  Fly   333 -----------RP------PKRGPVGLSLPPTHLSQHPQLKKHRLDNGDYAYENGHI-----SDM 375
                       ||      .:|.....:.|..||   ||:..        .|...|.     |..
Human   136 HQLWRGLSGAARPLPISAQSQRPGAAAARPAAHL---PQIFS--------KYPGSHYPEIVRSPC 189

  Fly   376 KSPLLANGYNPPPI--NHMAFMQMNAH--------HPGAAALMS--------------------- 409
            |.||   .|...|:  |::||....|:        ||.|||..:
Human   190 KPPL---NYETAPLQGNYVAFPSDPAYFRSLLCSKHPAAAAAAAAAAAAAAAAAAAAAYYQVSAA 251

  Fly   410 ------------PG-----------------MPPHG----LHARPESQMLKAAAQNAGMSAANMD 441
                        ||                 :.||.    |...|.|...||||..|..:||
Human   252 GPQPKAAAGAGGPGSLSYRCKRKRGGAKDCLLAPHAGARRLLLLPRSYKAKAAAAAAAAAAA--- 313

  Fly   442 ALARSGIWENCRAAYEDIVK-------------HLERLREERTDERQQAMGVGGAVVDRVGNVMV 493
            |.|.:|  ..|...:. :|.             |.......|....||:            :...
Human   314 AAAAAG--ATCLERFH-LVNGFCPPPHHHHHHHHHHHHHHHRAQPPQQS------------HHPP 363

  Fly   494 AEHKPR-DLSS--RNCSPTRQSPVLNLSKSGGNTDHGGSNCDAGSERSDCHSVAGSPARGGSRSL 555
            ..|:|: .|.|  .:||..        |:|...:||..::.|.||                  ||
Human   364 HHHRPQPHLGSFPESCSSD--------SESSSYSDHAANDSDFGS------------------SL 402

  Fly   556 DEGSRSGVGGGVASHVGGGIIGVEDDEEEEENLSDENQSEVDERCLAKDDEDLSDTERDNLSTGS 620
            ...|.|                |..:|||||...:|.:.|.:....|.|..::|..|.|: ||.|
Human   403 SSSSNS----------------VSSEEEEEEGEEEEEEEEEEGGSGASDSSEVSSEEEDS-STES 450

  Fly   621 AAAAAAAAAAAAHQLHQHAASHHHQTVGLSHLGVVPPHQRGSPSSAEAAAAALQHQRALNYSQLA 685
            .:::.::..:.             |::........      .|.|.:|.|..|.|        ||
Human   451 DSSSGSSQVSV-------------QSIRFRRTSFC------KPPSVQAQANFLYH--------LA 488

  Fly   686 AAAAVANGAAVGGGAVANGPTGGGGALTPNEALLAANDAAALAGGLALGPLGIDAHAAVPASSTE 750
            :|||....||.                         .||..|.          |..::|.|.|..
Human   489 SAAAATKPAAF-------------------------EDAGRLP----------DLKSSVKAESPA 518

  Fly   751 TLLRNIQSLLKVA-------------ADNARQQERQISYEKAELKMDVLREREVKDSLERQLVDE 802
            ..  |:||....|             |:....:..:|::..:|:...|.|.....:.|
Human   519 EW--NLQSWAPKASPVYCPASLGSCFAEIRNDRVSEITFPHSEISNAVKRTDLTINCL------- 574

  Fly   803 RKLRVLYQKRFRRERKIRIRYQQQLGGGSGAVKGSPNANGSGGGGSGSACSESEACGGGGGDAKC 867
                                       ..||...||..|.:  ........|:..|........|
Human   575 ---------------------------AEGASSPSPKTNNA--FPQQRILREARKCLQTTPTTHC 610

  Fly   868 NNNN-------NNNNNNNNSNSSSH------------------------GGDVETMKEN---DAG 898
            .:||       ||:::...:||..:                        .|...|..||   |.|
Human   611 ADNNTIAARFLNNDSSGAEANSEKYSKILHCPEFATDLPSSQTDPEVNAAGAAATKAENPCTDTG 675

  Fly   899 -------------------SEKSDKSLASNS-SCD----------VTAGHSAGSVSGSISAGLNC 933
                               :|:.:..|.:|. .|:          ||......::..:...|..|
Human   676 DKTLPFLHNIKIKVEDSSANEEYEPHLFTNKLKCECNDTKGEFYSVTESKEEDALLTTAKEGFAC 740

  Fly   934 PDSPTHFKREPSSDHEGSVERQPRSSAASLAA-----HDEDNTKRCGSRDR-------------- 979
            |:     |..||.:        |.:.:..|:.     ..||...:.|:|.|
Human   741 PE-----KETPSLN--------PLAQSQGLSCTLGSPKPEDGEYKFGARVRKNYRTLVLGKRPVL 792

  Fly   980 ----------DERPPSGSAASVAAEGSL--AAAAAAAAAAAAAAASNGKGPWSY-------PGID 1025
                      ..|.|..:..:...||:|  ..........|:..||..|.|:.:       |.:.
Human   793 QTPPVKPNLKSARSPRPTGKTETNEGTLDDFTVINRRKKVASNVASAVKRPFHFMANFPCPPSLI 857

  Fly  1026 LMATGAFWQNYSESLAQELEMERKSRAANAERDVKSPLSERPTAYYKNSVLFGSA 1080
            :...|..|..||               .|..:|.::|....|...::   |.|||
Human   858 IGRDGDLWPAYS---------------LNTTKDSQTPHKAHPIWKWQ---LGGSA 894

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dac	NP_723971.1	Ski_Sno	209..310	CDD:280577	24/88 (27%)
SKIDA1	NP_997254.3	Ski_Sno	10..95	CDD:308187	23/86 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	337..461		37/178 (21%)
		DUF4584	475..906	CDD:317608	91/532 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	744..763		4/26 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	792..818		2/25 (8%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3915
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900