DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dac and Dach1

DIOPT Version :9

Sequence 1:	NP_723971.1	Gene:	dac / 34982	FlyBaseID:	FBgn0005677	Length:	1081	Species:	Drosophila melanogaster
Sequence 2:	XP_038949891.1	Gene:	Dach1 / 306096	RGDID:	1592073	Length:	749	Species:	Rattus norvegicus

Alignment Length:	843	Identity:	238/843 - (28%)
Similarity:	327/843 - (38%)	Gaps:	281/843 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 AAAAAAAAAQQQQQQHNGRDGSNSSRGANEDRPNGRSSHTGRGSSCSPASSPSRHPSAVSPVSSL 114
            |::|:::||........|..|.....|.|        ...|.||:|:|:.:...:...
  Rat    61 ASSASSSAATTVTSPGGGGSGGGGGSGGN--------GGGGGGSNCNPSLAAGSNGGG------- 110

  Fly   115 NHSMMQQMQQQQQQQQQQQQQQQHHQLSPPPHGMPSGNGLPTGLPPRMPHGLPPHSLGLLNSLQM 179
                                           .|:.:|.|..:..|.....|....|....:|...
  Rat   111 -------------------------------GGVSAGGGGASSTPITASTGSSSSSSSSSSSSSS 144

  Fly   180 MHHASPLELMAAAHHHVPPRS-YNSPPPISTSDPSANECKLVEYRGQKVAAFIISNETMLCLPQA 243
            ...:|.....:::...:|.:. |::|.|:..: |..||||:|:.||.|||:|.:....::|||||
  Rat   145 SSSSSSSSSSSSSCGPLPGKPVYSTPSPVENT-PQNNECKMVDLRGAKVASFTVEGCELICLPQA 208

  Fly   244 FELFLKHLVGGLHTVYTKLKRLDIVPLVCNVEQVRILRGLGAIQPGVNRCKLLCCKDFDILYRDC 308
            |:||||||||||||||||||||:|.|:|||||||||||||||||||||||||:..|||:.||.||
  Rat   209 FDLFLKHLVGGLHTVYTKLKRLEITPVVCNVEQVRILRGLGAIQPGVNRCKLISRKDFETLYNDC 273

  Fly   309 TTARCLSIKPPESNSLQFRSSRPGRPPKRGPVGLSLPPTHLSQHPQLKKHRLDNGDYAYENGHIS 373
            |.|                ||||||||||         |.....|              ||.||.
  Rat   274 TNA----------------SSRPGRPPKR---------TQSVTSP--------------ENSHIM 299

  Fly   374 DMKSPLLANGYNPPPINHMAFMQMNAHHPGAAALMSPG-MPPHGLHARPESQMLKAAAQNAGMSA 437
            ....|                           .||||| :||.||.|      ..|||.||.::.
  Rat   300 PHSVP---------------------------GLMSPGIIPPTGLTA------AAAAAANAAIAE 331

  Fly   438 ANMDALARSGIWENCRAAYEDIVKHLERLREERTDERQQAMGVGGAVVDRVGNVMVAEHKPRDLS 502
            |                                                    :.|.:.|...:|
  Rat   332 A----------------------------------------------------MKVKKIKLEAMS 344

  Fly   503 SRNCSPTRQSPVLNLSKSGGNTDHGGSNCDAGSERSDCHSVAGSPARGGSRSLDEGSRSGVGGGV 567
            :.:.|               |..||     |.||..|.:|..||  .|||.. .|...|....|.
  Rat   345 NYHAS---------------NNQHG-----ADSENGDMNSSVGS--SGGSWD-KETLHSPPSQGS 386

  Fly   568 ASHVGGGIIGVEDDEEEEENLSDENQSEVDER----------------CLAKDDEDLSDTERDNL 616
            .:.|....|...........|:....|.:...                .|......::.::.::|
  Rat   387 QAPVAHARIPAAYSLPVSHPLNHLQHSHLPPNGLELPFMMMPHPLIPVSLPPASVTMAMSQMNHL 451

  Fly   617 STGSAAAAAAAAAAAAHQLH-------------------------QHAASHHHQTVGLSHLGVVP 656
            ||.:..||||...:...::.                         .|.:||...:|.
  Rat   452 STIANMAAAAQVQSPPSRVETSVIKERVPDSPSPAPSLEEGRRPGSHPSSHRSSSVS-------- 508

  Fly   657 PHQRGSPSSAEAAAAALQ-HQRALNYSQLAAAAAVANGAAVGGGAVANGPTGGGGA--------- 711
                .||:..|:::..:. ||..|:.:|:....:         ..|..||..|..|
  Rat   509 ----SSPARTESSSDRIPVHQNGLSMNQMLMGLS---------PNVLPGPKEGDLAGHDMGHESK 560

  Fly   712 ---LTPNEALLA------ANDAAALAG-GLALGPLGIDAHAAVP--ASSTETLLRNIQSLLKVAA 764
               :..:|..|:      :.|..:||| |..|.| |..:....|  .||.||||.|||.|||||.
  Rat   561 RIHIEKDETPLSTPTARDSMDKLSLAGHGQPLPP-GFPSPFLFPDGLSSIETLLTNIQGLLKVAI 624

  Fly   765 DNARQQERQISYEKAELKMDVLREREVKDSLERQLVDERKLRVLYQKRFRRERKIRIRYQQQL 827
            ||||.||:|:..||.|||||.|||||::::||:||..|:|.|.:.|||.::|:|.:.:.|:.|
  Rat   625 DNARAQEKQVQLEKTELKMDFLRERELRETLEKQLAMEQKNRAIVQKRLKKEKKAKRKLQEAL 687

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dac	NP_723971.1	Ski_Sno	209..310	CDD:280577	72/100 (72%)
Dach1	XP_038949891.1	DHD_Dac	180..274	CDD:410784	70/93 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352490
Domainoid	1	1.000	100	1.000	Domainoid score	I6867
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206899at33208
OrthoFinder	1	1.000	-	-		FOG0002588
OrthoInspector	1	1.000	-	-		otm46043
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12577
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1700
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	9.040