DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dac and DACH1

DIOPT Version :9

Sequence 1:	NP_723971.1	Gene:	dac / 34982	FlyBaseID:	FBgn0005677	Length:	1081	Species:	Drosophila melanogaster
Sequence 2:	NP_001353641.1	Gene:	DACH1 / 1602	HGNCID:	2663	Length:	758	Species:	Homo sapiens

Alignment Length:	843	Identity:	236/843 - (27%)
Similarity:	332/843 - (39%)	Gaps:	274/843 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 AAAAAAAQQQQQQHNGRDGSNSSRGANEDRPNGRSSHTGRGSSCSPASSPSRHPSAVSPVSSLNH 116
            |:|||||........|..|..|..|.......|.....|.||:|:|..:.:.:.|...
Human    61 ASAAAAAATVTSTGGGGGGGGSGGGGGSSGNGGGGGGGGGGSNCNPNLAAASNGSGGG------- 118

  Fly   117 SMMQQMQQQQQQQQQQQQQQQHHQLSPPPHGMPSGNGLPTGLPPRMPHGLPPHSLGLLNSLQMMH 181
                                        ..|:.:|.|:.:..|.....|   .|....:|.....
Human   119 ----------------------------GGGISAGGGVASSTPINASTG---SSSSSSSSSSSSS 152

  Fly   182 HASPLELMAAAHHHVPPRS-YNSPPPISTSDPSANECKLVEYRGQKVAAFIISNETMLCLPQAFE 245
            .:|.....:::...:|.:. |::|.|:..: |..||||:|:.||.|||:|.:....::||||||:
Human   153 SSSSSSSSSSSCGPLPGKPVYSTPSPVENT-PQNNECKMVDLRGAKVASFTVEGCELICLPQAFD 216

  Fly   246 LFLKHLVGGLHTVYTKLKRLDIVPLVCNVEQVRILRGLGAIQPGVNRCKLLCCKDFDILYRDCTT 310
            ||||||||||||||||||||:|.|:|||||||||||||||||||||||||:..|||:.||.|||.
Human   217 LFLKHLVGGLHTVYTKLKRLEITPVVCNVEQVRILRGLGAIQPGVNRCKLISRKDFETLYNDCTN 281

  Fly   311 ARCLSIKPPESNSLQFRSSRPGRPPKRGPVGLSLPPTHLSQHPQLKKHRLDNGDYAYENGHISDM 375
            |                ||||||||||         |.....|              ||.||...
Human   282 A----------------SSRPGRPPKR---------TQSVTSP--------------ENSHIMPH 307

  Fly   376 KSPLLANGYNPPPINHMAFMQMNAHHPGAAALMSPG-MPPHGLHARPESQMLKAAAQNAGMSAAN 439
            ..|                           .||||| :||.||.|   :....|||.||.::
Human   308 SVP---------------------------GLMSPGIIPPTGLTA---AAAAAAAATNAAIA--- 339

  Fly   440 MDALARSGIWENCRAAYEDIVKHLERLREERTDERQQAMGVGGAVVDRVGNVMVAEHKPRDLSSR 504
                                                :||.|....::.:.|...:.
Human   340 ------------------------------------EAMKVKKIKLEAMSNYHASN--------- 359

  Fly   505 NCSPTRQSPVLNLSKSGGNTDHGGSNCDAGSERS--DCHSVAGSPARGGSRSLDEGSRSGVGGGV 567
                         ::.|.::::|..|...||...  |..::..||::|...|:......|.....
Human   360 -------------NQHGADSENGDMNSSVGSSDGSWDKETLPSSPSQGPQASITHPRMPGARSLP 411

  Fly   568 ASHVGGGIIGVEDDEEEEENLSDENQSEVDER----------------CLAKDDEDLSDTERDNL 616
            .||                .|:...||.:...                .|......::.::.::|
Human   412 LSH----------------PLNHLQQSHLLPNGLELPFMMMPHPLIPVSLPPASVTMAMSQMNHL 460

  Fly   617 STGSAAAAAAAAAAAAHQLH-------------------------QHAASHHHQTVGLSHLGVVP 656
            ||.:..||||...:...::.                         .|.:||...:|.
Human   461 STIANMAAAAQVQSPPSRVETSVIKERVPDSPSPAPSLEEGRRPGSHPSSHRSSSVS-------- 517

  Fly   657 PHQRGSPSSAEAAAAALQ-HQRALNYSQLAAAAAVANGAAVGGGAVANGPTGGGGA--------- 711
                .||:..|:::..:. ||..|:.:|:....:         ..|..||..|..|
Human   518 ----SSPARTESSSDRIPVHQNGLSMNQMLMGLS---------PNVLPGPKEGDLAGHDMGHESK 569

  Fly   712 ---LTPNEALLA------ANDAAALAG-GLALGPLGIDAHAAVP--ASSTETLLRNIQSLLKVAA 764
               :..:|..|:      :.|..:|.| |..|.| |..:....|  .||.||||.|||.|||||.
Human   570 RMHIEKDETPLSTPTARDSLDKLSLTGHGQPLPP-GFPSPFLFPDGLSSIETLLTNIQGLLKVAI 633

  Fly   765 DNARQQERQISYEKAELKMDVLREREVKDSLERQLVDERKLRVLYQKRFRRERKIRIRYQQQL 827
            ||||.||:|:..||.|||||.|||||::::||:||..|:|.|.:.|||.::|:|.:.:.|:.|
Human   634 DNARAQEKQVQLEKTELKMDFLRERELRETLEKQLAMEQKNRAIVQKRLKKEKKAKRKLQEAL 696

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dac	NP_723971.1	Ski_Sno	209..310	CDD:280577	72/100 (72%)
DACH1	NP_001353641.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..105		14/43 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	134..185		9/54 (17%)
		Ski_Sno	181..281	CDD:308187	72/100 (72%)
		Interaction with SIX6 and HDAC3. /evidence=ECO:0000250	189..384		111/324 (34%)
		DACHbox-N	189..275		64/85 (75%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	280..302		15/60 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	358..414		11/77 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	474..532		7/69 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	544..564		5/28 (18%)
		ATP-synt_B	<615..730	CDD:328740	47/82 (57%)
		DACHbox-C	616..696		46/79 (58%)
		Interaction with SIN3A. /evidence=ECO:0000250	627..706		38/70 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158485
Domainoid	1	1.000	158	1.000	Domainoid score	I4116
eggNOG	1	0.900	-	-		E1_KOG3915
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2974
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206899at33208
OrthoFinder	1	1.000	-	-		FOG0002588
OrthoInspector	1	1.000	-	-		otm41907
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12577
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4062
SonicParanoid	1	1.000	-	-		X1700
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	11.020