DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dac and Dach1

DIOPT Version :9

Sequence 1:	NP_723971.1	Gene:	dac / 34982	FlyBaseID:	FBgn0005677	Length:	1081	Species:	Drosophila melanogaster
Sequence 2:	NP_031852.1	Gene:	Dach1 / 13134	MGIID:	1277991	Length:	751	Species:	Mus musculus

Alignment Length:	903	Identity:	247/903 - (27%)
Similarity:	343/903 - (37%)	Gaps:	323/903 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 TSEQSENNNNKAGAINNNINSGIERAAGNMNTTAMLMHHQQQQQAAAAAAAAAAQQQQQQHNGRD 69
            |:..|...::.|.:|....:||           ..|...:....:|:::|||..........|..
Mouse    30 TTSTSSATSSPAPSIGPPASSG-----------PTLFRPEPIASSASSSAAATVTSPGGGGGGSG 83

  Fly    70 GSNSSRGANEDRPNGRSSHTGRGSSCSPASSPSRHPSAVSPVSSLNHSMMQQMQQQQQQQQQQQQ 134
            |...|.|      ||    .|.||:|:|:.:.......||
Mouse    84 GGGGSGG------NG----GGGGSNCNPSLAAGSSGGGVS------------------------- 113

  Fly   135 QQQHHQLSPPPHGMPSGNGLPTGLPPRMPHGLPPHSLGLLNSLQMMHHASPLELMAAAHHHVPPR 199
                           :|.|..:..|.....|....|....:|......:|.....:::...:|.:
Mouse   114 ---------------AGGGGASSTPITASTGSSSSSSSSSSSSSSSSSSSSSSSSSSSCGPLPGK 163

  Fly   200 S-YNSPPPISTSDPSANECKLVEYRGQKVAAFIISNETMLCLPQAFELFLKHLVGGLHTVYTKLK 263
            . |::|.|:..: |..||||:|:.||.|||:|.:....::||||||:||||||||||||||||||
Mouse   164 PVYSTPSPVENT-PQNNECKMVDLRGAKVASFTVEGCELICLPQAFDLFLKHLVGGLHTVYTKLK 227

  Fly   264 RLDIVPLVCNVEQVRILRGLGAIQPGVNRCKLLCCKDFDILYRDCTTARCLSIKPPESNSLQFRS 328
            ||:|.|:|||||||||||||||||||||||||:..|||:.||.|||.|                |
Mouse   228 RLEITPVVCNVEQVRILRGLGAIQPGVNRCKLISRKDFETLYNDCTNA----------------S 276

  Fly   329 SRPGRPPKRGPVGLSLPPTHLSQHPQLKKHRLDNGDYAYENGHISDMKSPLLANGYNPPPINHMA 393
            |||||||||         |.....|              ||.||.....|
Mouse   277 SRPGRPPKR---------TQSVTSP--------------ENSHIMPHSVP--------------- 303

  Fly   394 FMQMNAHHPGAAALMSPG-MPPHGLHARPESQMLKAAAQNAGMSAANMDALARSGIWENCRAAYE 457
                        .||||| :||.||.|   :....|||.||.::.|
Mouse   304 ------------GLMSPGIIPPTGLTA---AAAAAAAATNAAIAEA------------------- 334

  Fly   458 DIVKHLERLREERTDERQQAMGVGGAVVDRVGNVMVAEHKPRDLSSRNCSPTRQSPVLNLSKSGG 522
                                             :.|.:.|...:|:.:.|
Mouse   335 ---------------------------------MKVKKIKLEAMSNYHAS--------------- 351

  Fly   523 NTDHGGSNCDAGSERSDCHSVAGSPARGGSRSLD-------EGSRSGVGGG--------VASHVG 572
            |..||     |.||..|.:|..||  .|||...:       :||::.|...        ..||
Mouse   352 NNQHG-----ADSENGDMNSSVGS--SGGSWDKETLHSPPSQGSQAPVAHARMPAAFSLPVSH-- 407

  Fly   573 GGIIGVEDDEEEEENLSDENQSEVDER----------------CLAKDDEDLSDTERDNLSTGSA 621
                          .|:....|.:...                .|......::.::.::|||.:.
Mouse   408 --------------PLNHLQHSHLPPNGLELPFMMMPHPLIPVSLPPASVTMAMSQMNHLSTIAN 458

  Fly   622 AAAAAAAAAAAHQLH-------------------------QHAASHHHQTVGLSHLGVVPPHQRG 661
            .||||...:...::.                         .|.:||...:|.            .
Mouse   459 MAAAAQVQSPPSRVETSVIKERVPDSPSPAPSLEEGRRPGSHPSSHRSSSVS------------S 511

  Fly   662 SPSSAEAAAAALQ-HQRALNYSQLAAAAAVANGAAVGGGAVANGPTGGGGA------------LT 713
            ||:..|:::..:. ||..|:.:|:....:         ..|..||..|..|            :.
Mouse   512 SPARTESSSDRIPVHQNGLSMNQMLMGLS---------PNVLPGPKEGDLAGHDMGHESKRIHIE 567

  Fly   714 PNEALLA------ANDAAALAG-GLALGPLGIDAHAAVP--ASSTETLLRNIQSLLKVAADNARQ 769
            .:|..|:      :.|..:|.| |..|.| |..:....|  .||.||||.|||.|||||.||||.
Mouse   568 KDETPLSTPTARDSIDKLSLTGHGQPLPP-GFPSPFLFPDGLSSIETLLTNIQGLLKVAIDNARA 631

  Fly   770 QERQISYEKAELKMDVLREREVKDSLERQLVDERKLRVLYQKRFRRERKIRIRYQQQL 827
            ||:|:..||.|||||.|||||::::||:||..|:|.|.:.|||.::|:|.:.:.|:.|
Mouse   632 QEKQVQLEKTELKMDFLRERELRETLEKQLAMEQKNRAIVQKRLKKEKKAKRKLQEAL 689

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dac	NP_723971.1	Ski_Sno	209..310	CDD:280577	72/100 (72%)
Dach1	NP_031852.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..178		36/209 (17%)
		Ski_Sno	174..274	CDD:280577	72/100 (72%)
		Interaction with SIX6 and HDAC3. /evidence=ECO:0000269\|PubMed:12130660	182..377		120/337 (36%)
		DACHbox-N	182..268		64/85 (75%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	273..295		15/60 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	351..393		16/63 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	467..525		7/69 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	537..556		5/27 (19%)
		ATP-synt_B	<608..723	CDD:304375	47/82 (57%)
		DACHbox-C	609..689		46/79 (58%)
		Interaction with SIN3A. /evidence=ECO:0000269\|PubMed:12130660	620..699		38/70 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848883
Domainoid	1	1.000	158	1.000	Domainoid score	I4114
eggNOG	1	0.900	-	-		E1_KOG3915
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	273	1.000	Inparanoid score	I2965
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002588
OrthoInspector	1	1.000	-	-		otm43955
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12577
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4062
SonicParanoid	1	1.000	-	-		X1700
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.970