Protein Alignment dac and dach2

DIOPT Version :10

• Sequence 1: NP_723971.1
• Gene: dac / 34982
• FlyBaseID: FBgn0005677
• Length: 1081
• Species: Drosophila melanogaster
• Sequence 2: XP_017951582.1
• Gene: dach2 / 100101662
• XenbaseID: XB-GENE-876613
• Length: 654
• Species: Xenopus tropicalis
• Alignment Length: 847
• Identity: 242/847 - (28%)
• Similarity: 328/847 - (38%)
• Gaps: 297/847 - (35%)

  Fly   141 LSPPP----HGMPSGNGL-----PTGLPPRMPHGLPPHSLGLLNSLQMMHHASPLELMAAAHHHV 196
            :|.||    ...|:..||     |....||         ||:|:|.                  |
 Frog     3 VSAPPVINATSTPASGGLYSSSSPAAESPR---------LGMLSSF------------------V 40

  Fly   197 PPRSYNSPPPISTSDP---SANECKLVEYRGQKVAAFIISNETMLCLPQAFELFLKHLVGGLHTV 258
            |          |.|.|   |::||::|:..|.|||:|::..:.::||||.|:|||||||||||||
 Frog    41 P----------SGSSPLAGSSSECRMVDLHGAKVASFVLEGQELICLPQVFDLFLKHLVGGLHTV 95

  Fly   259 YTKLKRLDIVPLVCNVEQVRILRGLGAIQPGVNRCKLLCCKDFDILYRDCTTARCLSIKPPESNS 323
            |||||||||.|:||.|||||:||||||||||||||||:..:||:.||.|||.|
 Frog    96 YTKLKRLDITPVVCTVEQVRVLRGLGAIQPGVNRCKLISRRDFETLYNDCTNA------------ 148

  Fly   324 LQFRSSRPGRPPKRGPVGLSLPPTHLSQHPQLKKHRLDNGDYAYENGHISDMKSPLLANGYNPPP 388
                ||||||||||. :|:.     :.::.:|..|
 Frog   149 ----SSRPGRPPKRS-LGVG-----IQENARLLPH------------------------------ 173

  Fly   389 INHMAFMQMNAHHPGAAALMSPG-MPPHGLHARPESQMLKAAAQNAGMSAANMDALARSGIWENC 452
                          |...|:||| :.|.||.|...::.:|  .|...|.|.|  :|..||.....
 Frog   174 --------------GVPGLLSPGLLSPTGLTAAAMAEAMK--LQKMKMMAIN--SLHGSGSQNGT 220

  Fly   453 RAAYEDIVKHLE----RLREERTDERQQAM-GVGGAVVDRV---GNVMVAEHKPRDLS-SRNCSP 508
            .:..|::..:.:    ||..:..||....: |...||..::   ...:.:|  |..|. ::||..
 Frog   221 ESENEELNSNADTSALRLLMQDADETLDPLPGPEVAVAPKIRCWTEGLTSE--PISLIWTKNCFI 283

  Fly   509 TRQSPVLNLSKSGGNTDHGGSNCDAGSERSDCHSVAGSPARGGSRSLDEGSRSGVGGGVASHV-- 571
            ...|.::           ||.   .|||.|.......||       :..||:.|:|     ||
 Frog   284 LPSSGIM-----------GGK---GGSESSWDKDKLQSP-------ITTGSQHGIG-----HVTL 322

  Fly   572 -GGGIIGVEDDEEEEENLSDENQSEVDERCLAKDDEDLSDTERDNLSTGSAAAA--------AAA 627
             |...:|.......::|....|:.::....:......:|      |...|.|.|        ..|
 Frog   323 SGQASLGAHPLSPLQQNHLLANRLDLPFMMMPHPLLPVS------LPPASVAMAMNQMNHLNTIA 381

  Fly   628 AAAAAHQLH--------------------------------QHAASHHHQTVGL--SHLGVVPPH 658
            ..|||.|:|                                .||:||...:|..  |.|..:|..
 Frog   382 NMAAAAQMHSPLSRVGASVIKERIQDTPSPAPSIEDTQRPGSHASSHQSSSVSSSPSQLDNIPDR 446

  Fly   659 QRGSPSSAEAAAAALQHQRALNYSQLAAAAAVANGAAVGGGAVANGPTGGGGALTPNEALLAAND 723
            ....|:|.|                               |.:.:..||     :..:.:|...|
 Frog   447 VALLPNSRE-------------------------------GEITDQDTG-----SSMKKMLKEKD 475

  Fly   724 AAALA-------------GGLALGP------LGIDAHAAVPASSTETLLRNIQSLLKVAADNARQ 769
            ...:|             .|..|.|      |..|.     .||.||||.|||.|||||.||||.
 Frog   476 EIQIAIPIMKPTLDKVQLAGQTLPPGFPSPFLFADG-----LSSVETLLTNIQGLLKVAVDNARV 535

  Fly   770 QERQISYEKAELKMDVLREREVKDSLERQLVDERKLRVLYQKRFRRERKIRIRYQQQLGGGSGAV 834
            ||:||..||.||||::.||||::::|||||..|.:.|...|||.::|:|.:.:.|:.|...|...
 Frog   536 QEKQIQQEKKELKMELCRERELRENLERQLTAELQSRATIQKRLKKEKKAKRKLQEALEFESKRR 600

  Fly   835 KGSPNANGSGGGGSG-----SAC-SESEACGGGGGDAKCNNNNNNNNNNNNSNSSSHGGDVETMK 893
            :....|......|.|     .|| .|.|                     ...|.|.|  |...|:
 Frog   601 EQVEQALKQATSGEGLRMLNDACIPEME---------------------TEHNGSQH--DSPPMQ 642

  Fly   894 EN 895
            ||
 Frog   643 EN 644

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dac	NP_723971.1	DHD_Dac	215..309	CDD:410784	64/93 (69%)
dach2	XP_017951582.1	DHD_Dac	52..146	CDD:410784	64/93 (69%)
		DUF5401	<534..>618	CDD:375164	33/83 (40%)