Protein Alignment CG5888 and TRIL

DIOPT Version :10

• Sequence 1: NP_609794.1
• Gene: CG5888 / 34980
• FlyBaseID: FBgn0028523
• Length: 455
• Species: Drosophila melanogaster
• Sequence 2: NP_055632.2
• Gene: TRIL / 9865
• HGNCID: 22200
• Length: 811
• Species: Homo sapiens
• Alignment Length: 498
• Identity: 105/498 - (21%)
• Similarity: 192/498 - (38%)
• Gaps: 132/498 - (26%)

  Fly    31 GCEAL--VKE---PNLCECQE-QEIKCENLQLHSDNLQLYGISCSIFDARGFGYIPPLKVGNIGS 89
            ||.||  :.|   |..|:||. |.:.|.|                    ||...:|
Human    15 GCLALPPLAEPVCPERCDCQHPQHLLCTN--------------------RGLRVVP--------- 50

  Fly    90 LIVQNCAIPNAESIKYLLSKLGVSNYTELEIFNY------------------FDPKKTDRGEVLQ 136
               :..::|:...:  |...||.:..|.:..|::                  ..||..::...|:
Human    51 ---KTSSLPSPHDV--LTYSLGGNFITNITAFDFHRLGQLRRLDLQYNQIRSLHPKTFEKLSRLE 110

  Fly   137 QHYTDHE-----------SLKKVSIIGFK----STLPENFLENLPALQQLSLKGSS--DLPGNIL 184
            :.|..:.           .|:|:.|:...    |.|.....|.|.:|.:|.|.|::  .||..:.
Human   111 ELYLGNNLLQALAPGTLAPLRKLRILYANGNEISRLSRGSFEGLESLVKLRLDGNALGALPDAVF 175

  Fly   185 HPLKNLTHLEIV---VKNLGKVSGAIFAKQSKLKHLMIDCDAKNSSVEMSA-FGPQELWHMTELQ 245
            .||.||.:|.:.   ::.|||.:   ||:..||:.|.:..:....|:..:| |.|     :..|.
Human   176 APLGNLLYLHLESNRIRFLGKNA---FAQLGKLRFLNLSANELQPSLRHAATFAP-----LRSLS 232

  Fly   246 SIEL-FNCGDNVPTELFWMSEQLAYIGIRSN-ISYLSKDFLKVQKKLLTLRLERNNIARLPDQLF 308
            |:.| .|...::...:|....:|..:.:|.| :::|:.:.....:.|..||||.|.:::||..|.
Human   233 SLILSANNLQHLGPRIFQHLPRLGLLSLRGNQLTHLAPEAFWGLEALRELRLEGNRLSQLPTALL 297

  Fly   309 RNTPLILEIHLAFNNLDRIQSGLFDKLKNLQVLNLEHNPITTIALNAFTPIPTAHIYVGKL---- 369
            .....:..:.|:.|.|..:....|..|..|:.|:|.:|.::.::.:.|...|.  :|...|
Human   298 EPLHSLEALDLSGNELSALHPATFGHLGRLRELSLRNNALSALSGDIFAASPA--LYRLDLDGNG 360

  Fly   370 ------FKAAKN--ADWARSTNATICEEEYIYGVCIYCK-----RDEYLDHFADSE----NCNKP 417
                  .:..|.  .||.        .:..:..|.:.|:     |.:|||:..|.:    :|..|
Human   361 WTCDCRLRGLKRWMGDWH--------SQGRLLTVFVQCRHPPALRGKYLDYLDDQQLQNGSCADP 417

  Fly   418 NPKAKDVLAKKAYENQLKAMPTHSWKK-------AKEYPVEEE 453
            :|.     |....:.:.:.:||.:.::       |:|.|.:.:
Human   418 SPS-----ASLTADRRRQPLPTAAGEEMTPPAGLAEELPPQPQ 455

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5888	NP_609794.1	LRR	<160..>359	CDD:443914	53/206 (26%)
		leucine-rich repeat	168..189	CDD:275380	8/22 (36%)
		leucine-rich repeat	190..213	CDD:275380	7/25 (28%)
		leucine-rich repeat	214..243	CDD:275380	6/29 (21%)
		leucine-rich repeat	244..266	CDD:275380	5/22 (23%)
		leucine-rich repeat	267..289	CDD:275380	4/22 (18%)
		leucine-rich repeat	290..313	CDD:275380	9/22 (41%)
		leucine-rich repeat	314..337	CDD:275380	5/22 (23%)
		leucine-rich repeat	338..357	CDD:275380	4/18 (22%)
TRIL	NP_055632.2	leucine-rich repeat	37..61	CDD:275380	7/55 (13%)
		LRR	61..>344	CDD:443914	66/292 (23%)
		LRR 1	61..81		5/21 (24%)
		leucine-rich repeat	62..84	CDD:275380	5/21 (24%)
		LRR 2	84..105		2/20 (10%)
		leucine-rich repeat	85..108	CDD:275380	2/22 (9%)
		LRR 3	108..129		2/20 (10%)
		leucine-rich repeat	109..132	CDD:275380	3/22 (14%)
		LRR 4	132..153		4/20 (20%)
		leucine-rich repeat	133..156	CDD:275380	5/22 (23%)
		LRR 5	156..177		6/20 (30%)
		leucine-rich repeat	157..180	CDD:275380	8/22 (36%)
		LRR 6	180..201		7/23 (30%)
		leucine-rich repeat	181..204	CDD:275380	7/25 (28%)
		LRR 7	204..223		4/18 (22%)
		leucine-rich repeat	205..254	CDD:275380	11/53 (21%)
		LRR 8	230..251		5/20 (25%)
		LRR 9	254..275		4/20 (20%)
		leucine-rich repeat	255..278	CDD:275380	4/22 (18%)
		LRR 10	278..299		9/20 (45%)
		leucine-rich repeat	279..302	CDD:275380	9/22 (41%)
		LRR 11	302..323		4/20 (20%)
		leucine-rich repeat	303..326	CDD:275380	5/22 (23%)
		LRR 12	326..347		5/20 (25%)
		leucine-rich repeat	327..346	CDD:275380	4/18 (22%)
		PCC	332..>401	CDD:188093	12/78 (15%)
		leucine-rich repeat	351..363	CDD:275378	2/11 (18%)
		PHA03378	<478..>579	CDD:223065
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	484..549
		FN3	589..667	CDD:473895