Protein Alignment CG5888 and IGFALS

DIOPT Version :10

• Sequence 1: NP_609794.1
• Gene: CG5888 / 34980
• FlyBaseID: FBgn0028523
• Length: 455
• Species: Drosophila melanogaster
• Sequence 2: NP_001139478.1
• Gene: IGFALS / 3483
• HGNCID: 5468
• Length: 643
• Species: Homo sapiens
• Alignment Length: 383
• Identity: 87/383 - (22%)
• Similarity: 139/383 - (36%)
• Gaps: 67/383 - (17%)

  Fly     5 LLLLSLIA--PSWQENATVINPSYVTKAGCEALVKEPNLCEC------QEQEIKC--ENLQLHSD 59
            |||||.:|  |...|.|....|.......|      |..|.|      .|..:.|  .||....|
Human    50 LLLLSWVALGPRSLEGADPGTPGEAEGPAC------PAACVCSYDDDADELSVFCSSRNLTRLPD 108

  Fly    60 NLQLYGISCSIFDARGFGYIPP-------------LKVGNIGSLIVQNCAIPNAESIKYLLSKLG 111
            .:. .|......|......:||             |:.|.:|||..|              :.||
Human   109 GVP-GGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQ--------------ALLG 158

  Fly   112 VSNYTELEIFNYFDPKKTDRGEVLQQHYTDHESLKKVSIIGFK----STLPENFLENLPALQQLS 172
            :.|...|.:         :|.::.............::.:|..    |.|.:...|.|.:|..|:
Human   159 LENLCHLHL---------ERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLN 214

  Fly   173 LKGSS--DLPGNILHPLKNLTHLEIVVKNLGKVSGAIFAKQSKLKHLMIDCDAKNSSVEMSAFGP 235
            |..:|  .||......|.:|..|.:....|..:..|:|:..::|:.|.:..:|      :.|...
Human   215 LGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNA------LRAIKA 273

  Fly   236 QELWHMTELQSIEL-FNCGDNVPTELFWMSEQLAYIGIRSN-ISYLSKDFLKVQKKLLTLRLERN 298
            .....:..||.:.| .|....|....|...:.|.::.:..| ::.|.:|.......|..|||..|
Human   274 NVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHN 338

  Fly   299 NIARLPDQLFRNTPLILEIHLAFNNLDRIQSGLFDKLKNLQVLNLEHNPITTIALNAF 356
            .||.|..:.|::...:.|:.|..|.:.::....|:.|..|:||.|:||.:..:...||
Human   339 AIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAF 396

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5888	NP_609794.1	LRR	<160..>359	CDD:443914	50/201 (25%)
		leucine-rich repeat	168..189	CDD:275380	7/22 (32%)
		leucine-rich repeat	190..213	CDD:275380	5/22 (23%)
		leucine-rich repeat	214..243	CDD:275380	4/28 (14%)
		leucine-rich repeat	244..266	CDD:275380	6/22 (27%)
		leucine-rich repeat	267..289	CDD:275380	4/22 (18%)
		leucine-rich repeat	290..313	CDD:275380	9/22 (41%)
		leucine-rich repeat	314..337	CDD:275380	5/22 (23%)
		leucine-rich repeat	338..357	CDD:275380	8/19 (42%)
IGFALS	NP_001139478.1	LRRNT	78..116	CDD:214470	10/44 (23%)
		leucine-rich repeat	95..113	CDD:275380	4/18 (22%)
		leucine-rich repeat	114..137	CDD:275380	3/22 (14%)
		LRR	132..574	CDD:443914	64/294 (22%)
		leucine-rich repeat	138..161	CDD:275380	8/36 (22%)
		leucine-rich repeat	162..185	CDD:275380	2/31 (6%)
		leucine-rich repeat	186..209	CDD:275380	5/22 (23%)
		leucine-rich repeat	210..233	CDD:275380	7/22 (32%)
		leucine-rich repeat	234..257	CDD:275380	5/22 (23%)
		leucine-rich repeat	258..281	CDD:275380	4/28 (14%)
		leucine-rich repeat	282..305	CDD:275380	6/22 (27%)
		leucine-rich repeat	306..324	CDD:275380	4/17 (24%)
		leucine-rich repeat	354..377	CDD:275380	5/22 (23%)
		leucine-rich repeat	378..401	CDD:275380	8/19 (42%)
		leucine-rich repeat	402..423	CDD:275380
		leucine-rich repeat	426..447	CDD:275380
		leucine-rich repeat	450..473	CDD:275380
		leucine-rich repeat	474..497	CDD:275380
		leucine-rich repeat	498..519	CDD:275380
		leucine-rich repeat	522..543	CDD:275380
		leucine-rich repeat	546..565	CDD:275380
		LRRCT	574..618	CDD:214507