DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5888 and egg-6

DIOPT Version :9

Sequence 1:	NP_001285981.1	Gene:	CG5888 / 34980	FlyBaseID:	FBgn0028523	Length:	455	Species:	Drosophila melanogaster
Sequence 2:	NP_492348.1	Gene:	egg-6 / 172670	WormBaseID:	WBGene00010621	Length:	961	Species:	Caenorhabditis elegans

Alignment Length:	506	Identity:	109/506 - (21%)
Similarity:	182/506 - (35%)	Gaps:	182/506 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 SLIVQNCAIPNAESIKYLLSKLGVSNYTELEIFN-------------------------YFDPKK 128
            |:|:.:|   |.|.:|.:...:|.|...||.|.|                         .|.|..
Worm    37 SMIILSC---NGEDVKTIAQTVGTSQIDELHILNGTDVKIESLPFNGLRTIAILNSTLQSFSPTA 98

  Fly   129 TDRGEVLQQHYT-DHESLKKVSIIGFKSTL-------------PENFLENLPALQQLSLKGSS-- 177
            ....|...:|.| :...||.|.:.|..|||             |:.....|.||.||.|:.::
Worm    99 WRHVEATIEHITINGNELKTVPVFGNLSTLMSMNLNSNQISSIPDKAFNGLSALTQLRLENNAIC 163

  Fly   178 DLPGNILHPLK-NLTHLEIVVKNLGKVSGAIFAKQSKLKHLMIDCDAKNSSVEMSAFGPQELWHM 241
            |.|...|..:| :|..|::....|..:...|....:.|.:|  |..:.|.| |::.|   ||.::
Worm   164 DFPPKSLDAVKASLVLLDVSGNCLDAIPAQILRNAANLMYL--DLGSNNIS-EINNF---ELMNL 222

  Fly   242 TELQSIELFN---------CGDNVPTELFWMSEQLAYIGIRSN-ISYLS---------------- 280
            ..|:.:.:.|         ...|||        ||.|:.::.| ||.|.
Worm   223 PFLRELRVQNNTLRRIHPMAFMNVP--------QLQYLYLQDNIISTLDGNRLQGFKNLEVLDVS 279

  Fly   281 ----------KDF-----LKVQKKLLT---------------LRLERNNIARLPDQLFRNTPLIL 315
                      ||.     ::|...|:|               :.::.|||.::....|.:...::
Worm   280 NNALYALPSLKDLPNLKQVRVDGNLITKIETLAFSNNPNLQLISVQNNNIVQISRNSFESLDKLV 344

  Fly   316 EIHLAFNNLDRIQSGLFDKLKNLQVLNLEHNPITTIALNAFTPIPTAHI---------------- 364
            .:.:..|:|.:|:.|:||.:||||.|::.:|.:|.:..::|..:  ||:
Worm   345 VLLVGNNSLAKIERGMFDGMKNLQQLSIRNNTLTALDASSFAQL--AHLTTLDLGHNKIHDIEEG 407

  Fly   365 ---YVGKL------------FKAA----KNADWARSTNATICEEEYIYGVCIYCKRDEYLDH--- 407
               .:.||            ||.:    |.::.....|..||:|.:          :|:|.:
Worm   408 TFDKLSKLFWLDLSNNKISGFKTSVFKKKISNILLDGNQLICDESF----------NEFLTYLIA 462

  Fly   408 --------FADSENCNKPNPKA----KDVLAKKAYE-----NQLKAMPTHS 441
                    |.....|:.|...|    ||::.|||.|     ::|..:|..|
Worm   463 NKVRTFLPFQQEIMCHGPEKYAGVRLKDLMMKKANETLSEGSRLLGVPQGS 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5888	NP_001285981.1	leucine-rich repeat	168..189	CDD:275380	8/23 (35%)
		leucine-rich repeat	190..213	CDD:275380	4/22 (18%)
		leucine-rich repeat	214..243	CDD:275380	9/28 (32%)
		leucine-rich repeat	244..266	CDD:275380	5/30 (17%)
		leucine-rich repeat	267..289	CDD:275380	9/53 (17%)
		LRR_8	288..348	CDD:290566	18/74 (24%)
		leucine-rich repeat	290..313	CDD:275380	6/37 (16%)
		leucine-rich repeat	314..337	CDD:275380	6/22 (27%)
		leucine-rich repeat	338..357	CDD:275380	5/18 (28%)
egg-6	NP_492348.1	LRR_8	107..162	CDD:290566	16/54 (30%)
		leucine-rich repeat	107..127	CDD:275380	6/19 (32%)
		leucine-rich repeat	128..151	CDD:275380	3/22 (14%)
		LRR_RI	<144..281	CDD:238064	35/150 (23%)
		leucine-rich repeat	152..200	CDD:275380	12/47 (26%)
		LRR_8	176..233	CDD:290566	14/62 (23%)
		leucine-rich repeat	201..224	CDD:275380	9/28 (32%)
		LRR_8	225..283	CDD:290566	12/65 (18%)
		leucine-rich repeat	225..248	CDD:275380	5/30 (17%)
		LRR_RI	<240..458	CDD:238064	45/237 (19%)
		leucine-rich repeat	249..272	CDD:275380	6/22 (27%)
		LRR_8	271..329	CDD:290566	6/57 (11%)
		leucine-rich repeat	273..294	CDD:275380	2/20 (10%)
		leucine-rich repeat	295..318	CDD:275380	3/22 (14%)
		LRR_8	317..375	CDD:290566	15/57 (26%)
		leucine-rich repeat	319..342	CDD:275380	4/22 (18%)
		leucine-rich repeat	343..366	CDD:275380	6/22 (27%)
		LRR_8	365..425	CDD:290566	12/61 (20%)
		leucine-rich repeat	367..390	CDD:275380	6/24 (25%)
		leucine-rich repeat	391..414	CDD:275380	0/22 (0%)
		leucine-rich repeat	415..434	CDD:275380	3/18 (17%)
		leucine-rich repeat	437..449	CDD:275378	1/11 (9%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000