DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CaBP1 and EPS1

DIOPT Version :9

Sequence 1:	NP_001285979.1	Gene:	CaBP1 / 34976	FlyBaseID:	FBgn0025678	Length:	433	Species:	Drosophila melanogaster
Sequence 2:	NP_012261.1	Gene:	EPS1 / 854812	SGDID:	S000001267	Length:	701	Species:	Saccharomyces cerevisiae

Alignment Length:	254	Identity:	64/254 - (25%)
Similarity:	100/254 - (39%)	Gaps:	67/254 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LLAFVVGSVSAFYSPSDGVVE-LTPSNFDREVLKDDAIWVVEFYAPWCGHCQSLVP-------EY 65
            ||.|.:.:.    .|.:|..| |.|:||..|:.|  .:.:::||:|:|.||:.|.|       |:
Yeast    19 LLKFTIAAA----EPPEGFPEPLNPTNFKEELSK--GLHIIDFYSPYCPHCKHLAPVWMETWEEF 77

  Fly    66 KKLAKALKGVVKVGSVNADADSTLSGQFGVRGFPTIKIFGANKKSPTDY-----NGQRTAKAIAE 125
            |:.:|.|.  :....||....:.|.|...:..||.|:::     :|:.|     ...||.:::
Yeast    78 KEESKTLN--ITFSQVNCIESADLCGDENIEYFPEIRLY-----NPSGYIKSFTETPRTKESL-- 133

  Fly   126 AALAEVKKKVQGVLGGGGGSSSGGSGSSSGDDVIEL---------------TEDNFDKLVLNSDD 175
            .|.|..:......|.....|:...|....|.|.:||               |:|     :.||||
Yeast   134 IAFARRESMDPNNLDTDLDSAKSESQYLEGFDFLELIAGKATRPHLVSFWPTKD-----MKNSDD 193

  Fly   176 IWLVEFFAPWCGHCKNLAPEWAKAAKELKGKVKLGALD--ATAHQSKAAEYNVRGYPTI 232
              .:||  ..|..|......|...:::|       |:|  .|.|      .|....|||
Yeast   194 --SLEF--KNCDKCHEFQRTWKIISRQL-------AVDDINTGH------VNCESNPTI 235

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CaBP1	NP_001285979.1	PDI_a_P5	26..119	CDD:239299	29/105 (28%)
		PDI_a_P5	157..262	CDD:239299	23/93 (25%)
		Thioredoxin_6	190..383	CDD:290560	10/45 (22%)
		P5_C	271..400	CDD:239281
EPS1	NP_012261.1	Thioredoxin	33..139	CDD:395038	32/116 (28%)
EPS1	NP_012261.1	PTZ00102	<404..>472	CDD:240266
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0191
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900