DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CaBP1 and MPD1

DIOPT Version :9

Sequence 1:	NP_001285979.1	Gene:	CaBP1 / 34976	FlyBaseID:	FBgn0025678	Length:	433	Species:	Drosophila melanogaster
Sequence 2:	NP_014931.3	Gene:	MPD1 / 854462	SGDID:	S000005814	Length:	318	Species:	Saccharomyces cerevisiae

Alignment Length:	153	Identity:	53/153 - (34%)
Similarity:	80/153 - (52%)	Gaps:	20/153 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LASILLLAFVVGSVSA--FYSPSDGVVELTPSNFDREVLKDDAIWVVEFYAPWCGHCQSLVPEYK 66
            :..:||..|::..|.|  ||.....:.||||.:||:.:...:...:|||||||||||:.|...::
Yeast     6 IIKLLLGLFIMNEVKAQNFYDSDPHISELTPKSFDKAIHNTNYTSLVEFYAPWCGHCKKLSSTFR 70

  Fly    67 KLAKALKGVVKVGSVNAD--ADSTLSGQFGVRGFPTIKIFGANK---KSPTD------------- 113
            |.||.|.|||:|.:||.|  .:..|..::.|.||||:.:|...|   ..|.|
Yeast    71 KAAKRLDGVVQVAAVNCDLNKNKALCAKYDVNGFPTLMVFRPPKIDLSKPIDNAKKSFSAHANEV 135

  Fly   114 YNGQRTAKAIAEAALAEVKKKVQ 136
            |:|.||...|.:.:|:.::..|:
Yeast   136 YSGARTLAPIVDFSLSRIRSYVK 158

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CaBP1	NP_001285979.1	PDI_a_P5	26..119	CDD:239299	41/110 (37%)
		PDI_a_P5	157..262	CDD:239299
		Thioredoxin_6	190..383	CDD:290560
		P5_C	271..400	CDD:239281
MPD1	NP_014931.3	ER_PDI_fam	30..>275	CDD:273457	46/129 (36%)
MPD1	NP_014931.3	PDI_a_MPD1_like	30..150	CDD:239300	44/119 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	79	1.000	Domainoid score	I2043
eggNOG	1	0.900	-	-		E2759_KOG0191
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1409
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000934
OrthoInspector	1	1.000	-	-		oto99886
orthoMCL	1	0.900	-	-		OOG6_100473
Panther	1	1.100	-	-	LDO	PTHR45815
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2193
SonicParanoid	1	1.000	-	-		X1799
TreeFam	0	0.000	Not matched by this tool.
	10	9.790