Protein Alignment CaBP1 and TXNDC5

DIOPT Version :10

• Sequence 1: NP_609792.1
• Gene: CaBP1 / 34976
• FlyBaseID: FBgn0025678
• Length: 433
• Species: Drosophila melanogaster
• Sequence 2: NP_110437.2
• Gene: TXNDC5 / 81567
• HGNCID: 21073
• Length: 432
• Species: Homo sapiens
• Alignment Length: 260
• Identity: 88/260 - (33%)
• Similarity: 138/260 - (53%)
• Gaps: 39/260 - (15%)

  Fly    26 GVVELTPSNFDREVLKDDAIWVVEFYAPWCGHCQSLVPEYKKLAKALK--GVVKVGSVNADADST 88
            |:.||:.|||:..|.:.|..  ::|:|||||||::|.|.:::||..|:  ..||:|.|:......
Human   190 GLYELSASNFELHVAQGDHF--IKFFAPWCGHCKALAPTWEQLALGLEHSETVKIGKVDCTQHYE 252

  Fly    89 LSGQFGVRGFPTIKIFGANKKSPTDYNGQRTAKAIAEAALAEVKKKVQG-----------VLGGG 142
            |.....|||:||:..|...|| ...|.|:|..:::.|...:::::...|           ||...
Human   253 LCSGNQVRGYPTLLWFRDGKK-VDQYKGKRDLESLREYVESQLQRTETGATETVTPSEAPVLAAE 316

  Fly   143 GGSSSGGSGSSSGDDVIELTEDNFDKLVLNSDDIWLVEFFAPWCGHCKNLAPEWAKAAKE----L 203
            ..:..|        .|:.|||:|||..:  ::.|..::|:||||||||.|||.|.:.:|:    |
Human   317 PEADKG--------TVLALTENNFDDTI--AEGITFIKFYAPWCGHCKTLAPTWEELSKKEFPGL 371

  Fly   204 KGKVKLGALDATAHQSKAAEYNVRGYPTIKFFPAGSKRASDAQEYDGGRTASD----IVSWASDK 264
            .| ||:..:|.||.::..::|:||||||:..|..|.|    ..|:.|||....    ::|.|.|:
Human   372 AG-VKIAEVDCTAERNICSKYSVRGYPTLLLFRGGKK----VSEHSGGRDLDSLHRFVLSQAKDE 431

  Fly   265  264
            Human   432  431

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CaBP1	NP_609792.1	PDI_a_P5	26..119	CDD:239299	36/94 (38%)
		PDI_a_P5	157..262	CDD:239299	44/112 (39%)
		P5_C	271..400	CDD:239281
TXNDC5	NP_110437.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	40..63
		PDI_a_ERp46	61..164	CDD:239303
		PDI_a_ERp46	190..290	CDD:239303	38/102 (37%)
		PDI_a_ERp46	323..424	CDD:239303	43/107 (40%)
		Prevents secretion from ER. /evidence=ECO:0000255|PROSITE-ProRule:PRU10138	429..432		1/3 (33%)