DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CaBP1 and Pdia5

DIOPT Version :9

Sequence 1:	NP_001285979.1	Gene:	CaBP1 / 34976	FlyBaseID:	FBgn0025678	Length:	433	Species:	Drosophila melanogaster
Sequence 2:	NP_082571.1	Gene:	Pdia5 / 72599	MGIID:	1919849	Length:	517	Species:	Mus musculus

Alignment Length:	412	Identity:	99/412 - (24%)
Similarity:	176/412 - (42%)	Gaps:	64/412 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 AFVVGSVSAFYSPSDG------------VVEL-TPSNFDREVLKDDAIWVVEFYAPWCGHCQSLV 62
            |..:.|:.||.....|            ||.: :..:|.|.:.:::...::.||||||..|:.::
Mouse   123 AVTLKSIVAFLKDPKGPPLWEEDPGAKDVVHIDSEKDFRRLLKREEKPLLMMFYAPWCSMCKRIM 187

  Fly    63 PEYKKLAKALKGVVKVGSVNA--DADSTLSGQFGVRGFPTIKIFGANKKSPTDYNGQRTAKAIAE 125
            |.::|.|..::|.:.:..:|.  .....:..::.|||:|||..|...:......|...||:.|.|
Mouse   188 PHFQKAATQVRGHIVLAGMNVYPSEFENIKEEYNVRGYPTICYFEKGRFLFPYENYGSTAEDIVE 252

  Fly   126 AALAEVKKKVQGVLGGGGGSSSGGSGSSSGDDVIELTEDNFDKLVLNSDDIWLVEFFAPWCGHCK 190
            .....:..:.|  :.....:..|||       |..||:::||:.|.....: ||.|.||||||||
Mouse   253 WLKNPLPPQPQ--VPETPWADEGGS-------VYHLTDEDFDQFVKEHSSV-LVMFHAPWCGHCK 307

  Fly   191 NLAPEWAKAAKELKGKVK----LGALDATAHQSKAAEYNVRGYPTIKFFPAGSKRASDAQEYDGG 251
            .:.||:..||:.|.|..:    |.|:|||.:::.|..:::..:||:|:|..|.::|..|.
Mouse   308 KMKPEFESAAEVLHGDAESSGVLAAVDATVNEALAGRFHISAFPTLKYFKNGEQQAVPAL----- 367

  Fly   252 RTASDIVSWASDKHVANVPAP-------ELIEIINESTFETACEGKPLCVVSVLPHILDCDAKCR 309
            ||....:.|..:......|.|       .::.::.::..:|..:.|...|:...|....|
Mouse   368 RTKKKFIEWMQNPEAPPPPEPTWEEQQTSVLHLVGDNFRDTLKKKKHTLVMFYAPWCPHC----- 427

  Fly   310 NKFLDTLRTLGEKFKQKQWGWAWA-----EGGQQLALEESLEVGGFGYPAMAVVNFKKMKFSVLK 369
            .|.:.......:.||:.:.....|     :..|.|..:|:::    .||.....::.|     |.
Mouse   428 KKVIPHFTATADAFKEDRKIACAAVDCVKDKNQDLCQQEAVK----AYPTFHYYHYGK-----LV 483

  Fly   370 GSFSKD----GINEFLRDISYG 387
            ..:..|    |...|:|.:..|
Mouse   484 EKYESDRTELGFTSFIRTLREG 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CaBP1	NP_001285979.1	PDI_a_P5	26..119	CDD:239299	25/107 (23%)
		PDI_a_P5	157..262	CDD:239299	39/108 (36%)
		Thioredoxin_6	190..383	CDD:290560	44/212 (21%)
		P5_C	271..400	CDD:239281	22/133 (17%)
Pdia5	NP_082571.1	PDI_b_PDIR_N	26..137	CDD:239365	4/13 (31%)
		PTZ00102	122..517	CDD:240266	99/412 (24%)
		PDI_a_PDIR	150..254	CDD:239295	28/103 (27%)
		PDI_a_PDIR	275..377	CDD:239295	39/114 (34%)
		PDI_a_PDIR	396..499	CDD:239295	18/116 (16%)
		Prevents secretion from ER. /evidence=ECO:0000255\|PROSITE-ProRule:PRU10138	514..517
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0191
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810