DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CaBP1 and Erp27

DIOPT Version :9

Sequence 1:	NP_001285979.1	Gene:	CaBP1 / 34976	FlyBaseID:	FBgn0025678	Length:	433	Species:	Drosophila melanogaster
Sequence 2:	NP_081259.1	Gene:	Erp27 / 69187	MGIID:	1916437	Length:	272	Species:	Mus musculus

Alignment Length:	271	Identity:	49/271 - (18%)
Similarity:	86/271 - (31%)	Gaps:	88/271 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   157 DVIELTEDNFDKLVLNSDDIWLVEFFAPWCGHCKNLAPEWAKAAKELKGKVKLGALDATAHQSKA 221
            ||.|.|    |.|....:.|||.:                               :.||.....|
Mouse    26 DVEEAT----DGLSTTQEPIWLTD-------------------------------VPATVELIAA 55

  Fly   222 AEYNVRGY------PTIKFFPAGSKRASDAQ-----------EYDGGRTASDIVSWASDKH---- 265
            ||..|.|:      |.:..|.:.:::..|..           .|:....:..:.....|:.
Mouse    56 AEVAVIGFFQDLEIPIVSVFRSMARQFQDVSFGISNHSEVLTHYNVTSNSICLFRLVDDQQLHLN 120

  Fly   266 ---VANVPAPELIEIINESTFETACEGKPLCVVS-----VLPHILDCDAKCRNKFLDTLRTLGE- 321
               :.|:.|.:|...|:.:......|..|:....     |..|:|....|...::.:::|...|
Mouse   121 AEDIENLDAAKLSRFIHVNNLHWVTEYSPMIAAGLFNTMVQTHLLLMMKKTSPEYEESMRRYREA 185

  Fly   322 -KFKQKQWGWAWAEGGQQ------------------LALEESLEVGGFGYPAMAVVNFKKMK--- 364
             |..|.|..:...:.|::                  ||:.||::......| :|.|..:|::
Mouse   186 AKLFQGQILFVLVDSGKRENGKVMSYFKLKESQLPALAIYESVDDKWDTLP-IAEVTVEKVRGFC 249

  Fly   365 FSVLKGSFSKD 375
            ...|||...:|
Mouse   250 EGFLKGLLQRD 260

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CaBP1	NP_001285979.1	PDI_a_P5	26..119	CDD:239299
		PDI_a_P5	157..262	CDD:239299	20/121 (17%)
		Thioredoxin_6	190..383	CDD:290560	40/238 (17%)
		P5_C	271..400	CDD:239281	27/133 (20%)
Erp27	NP_081259.1	Thioredoxin_6	64..250	CDD:372755	29/186 (16%)
		PDIA3-binding site. /evidence=ECO:0000250\|UniProtKB:Q96DN0	230..233		0/2 (0%)
		Prevents secretion from ER. /evidence=ECO:0000250\|UniProtKB:Q96DN0	269..272
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0191
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900