DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CaBP1 and TMX3

DIOPT Version :9

Sequence 1:	NP_001285979.1	Gene:	CaBP1 / 34976	FlyBaseID:	FBgn0025678	Length:	433	Species:	Drosophila melanogaster
Sequence 2:	NP_061895.3	Gene:	TMX3 / 54495	HGNCID:	24718	Length:	454	Species:	Homo sapiens

Alignment Length:	287	Identity:	82/287 - (28%)
Similarity:	126/287 - (43%)	Gaps:	82/287 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   156 DDVIELTEDNFDKLVLNSDDIWLVEFFAPWCGHCKNLAPEWAKAAKELK---GKVKLGALDATAH 217
            :|:.|..::|      .:||||||:|:||||||||.|.|.|.:...|:|   ..||:|.:|||::
Human    29 EDLDESFKEN------RNDDIWLVDFYAPWCGHCKKLEPIWNEVGLEMKSIGSPVKVGKMDATSY 87

  Fly   218 QSKAAEYNVRGYPTIKFFPAGSKRASDAQEYDGGRTASDIVSWA---SDKHVANVPAPELIEIIN 279
            .|.|:|:.||||||||..     :...|..|.|.||..||:.:|   |...:..:|:.::.|.:.
Human    88 SSIASEFGVRGYPTIKLL-----KGDLAYNYRGPRTKDDIIEFAHRVSGALIRPLPSQQMFEHMQ 147

  Fly   280 E--STFETACEGK-PLCVVSVLPHILDCDAKCRNKFLDTLR--------------------TLGE 321
            :  ..|.....|: ||                :.|::|...                    ||.|
Human   148 KRHRVFFVYVGGESPL----------------KEKYIDAASELIVYTYFFSASEEVVPEYVTLKE 196

  Fly   322 K-----FKQKQW------------GWAWAEGGQQ-LALEESL--EVGGFG-YPAMAVVNFK--KM 363
            .     ||.:.:            .|...|..|. ||::..|  |:|..| ..|:||::.|  .:
Human   197 MPAVLVFKDETYFVYDEYEDGDLSSWINRERFQNYLAMDGFLLYELGDTGKLVALAVIDEKNTSV 261

  Fly   364 KFSVLKG---SFSKDGINEFLRDISYG 387
            :.:.||.   ..::|..:.|.||..:|
Human   262 EHTRLKSIIQEVARDYRDLFHRDFQFG 288

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CaBP1	NP_001285979.1	PDI_a_P5	26..119	CDD:239299
		PDI_a_P5	157..262	CDD:239299	48/110 (44%)
		Thioredoxin_6	190..383	CDD:290560	62/247 (25%)
		P5_C	271..400	CDD:239281	32/166 (19%)
TMX3	NP_061895.3	PDI_a_TMX3	27..130	CDD:239298	48/111 (43%)
		ER_PDI_fam	29..>346	CDD:273457	82/287 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	412..454
		Di-lysine motif	451..454
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910