DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CaBP1 and DNAJC10

DIOPT Version :9

Sequence 1:	NP_001285979.1	Gene:	CaBP1 / 34976	FlyBaseID:	FBgn0025678	Length:	433	Species:	Drosophila melanogaster
Sequence 2:	NP_061854.1	Gene:	DNAJC10 / 54431	HGNCID:	24637	Length:	793	Species:	Homo sapiens

Alignment Length:	389	Identity:	97/389 - (24%)
Similarity:	168/389 - (43%)	Gaps:	86/389 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LLAFVVGSVSAFYSPSDGVVELTPSNFDREVLKDDAIWVVEFYAPWCGHCQSLVPEYKKLAKALK 73
            :|||...||::.      |..|.|.||.   ..|...|:|:|:||||..|::|:||.::.:..|.
Human   443 ILAFAKESVNSH------VTTLGPQNFP---ANDKEPWLVDFFAPWCPPCRALLPELRRASNLLY 498

  Fly    74 GVVKVGSVNADADSTLSGQFGVRGFPTIKIFGANKKSPTDYNGQRTAKAIAEAALAEVKKKVQGV 138
            |.:|.|:::......|...:.::.:||..:|  |:.:..:|.|..:|:.|.|.        ::.:
Human   499 GQLKFGTLDCTVHEGLCNMYNIQAYPTTVVF--NQSNIHEYEGHHSAEQILEF--------IEDL 553

  Fly   139 LGGGGGSSSGGSGSSSGDDVIELTEDNFDKLVL--NSDDIWLVEFFAPWCGHCKNLAPEWAKAAK 201
            :               ...|:.||...|::||.  ..:::|:|:|::|||..|:.|.|||.:.|:
Human   554 M---------------NPSVVSLTPTTFNELVTQRKHNEVWMVDFYSPWCHPCQVLMPEWKRMAR 603

  Fly   202 ELKGKVKLGALDATAHQSKAAEYNVRGYPTIKFFPAGSKRASDAQEYDGGRTASDIVSWASDKHV 266
            .|.|.:.:|::|...:.|..|:.||:.||.|:|||..|.:|.....|:|         |..|.:.
Human   604 TLTGLINVGSIDCQQYHSFCAQENVQRYPEIRFFPPKSNKAYHYHSYNG---------WNRDAYS 659

  Fly   267 ANVPA----PELIEIINESTF-ETACEGK---------PLCVVSVLPHILDCDAKCRNKFLDTLR 317
            ..:..    |::...:...|| |...:||         |.|            ..|:| |.....
Human   660 LRIWGLGFLPQVSTDLTPQTFSEKVLQGKNHWVIDFYAPWC------------GPCQN-FAPEFE 711

  Fly   318 TLGEKFKQKQWGWAWAEGGQ---QLALEESLEVGGFGYPAMAVVNFKKMKFSVLKGSFSKDGIN 378
            .|....|.|      .:.|:   |...:...:.|...||.:....:::     .|.:|.::.||
Human   712 LLARMIKGK------VKAGKVDCQAYAQTCQKAGIRAYPTVKFYFYER-----AKRNFQEEQIN 764

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CaBP1	NP_001285979.1	PDI_a_P5	26..119	CDD:239299	28/92 (30%)
		PDI_a_P5	157..262	CDD:239299	37/106 (35%)
		Thioredoxin_6	190..383	CDD:290560	48/206 (23%)
		P5_C	271..400	CDD:239281	23/125 (18%)
DNAJC10	NP_061854.1	DnaJ	34..>132	CDD:223560
		PDI_a_ERdj5_N	129..229	CDD:239301
		Trxb 1	235..350
		Trxb 2	348..463		8/25 (32%)
		PDI_a_ERdj5_C	453..550	CDD:239302	31/115 (27%)
		PDI_a_ERdj5_C	556..663	CDD:239302	38/115 (33%)
		PDI_a_ERdj5_C	670..775	CDD:239302	22/119 (18%)
		Prevents secretion from ER. /evidence=ECO:0000255\|PROSITE-ProRule:PRU10138	790..793
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0191
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810