DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CaBP1 and P4HB

DIOPT Version :9

Sequence 1:	NP_001285979.1	Gene:	CaBP1 / 34976	FlyBaseID:	FBgn0025678	Length:	433	Species:	Drosophila melanogaster
Sequence 2:	XP_024306545.1	Gene:	P4HB / 5034	HGNCID:	8548	Length:	546	Species:	Homo sapiens

Alignment Length:	286	Identity:	85/286 - (29%)
Similarity:	124/286 - (43%)	Gaps:	68/286 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   156 DDVIELTEDNFDKLVLNSDDIWLVEFFAPWCGHCKNLAPEWAKAAKELK---GKVKLGALDATAH 217
            |.|:.|.:.||.: .|.:....||||:||||||||.||||:||||.:||   .:::|..:|||..
Human    24 DHVLVLRKSNFAE-ALAAHKYLLVEFYAPWCGHCKALAPEYAKAAGKLKAEGSEIRLAKVDATEE 87

  Fly   218 QSKAAEYNVRGYPTIKFFPAGSKRASDAQEYDGGRTASDIVSWASDKHVANVPAPELIEIINEST 282
            ...|.:|.||||||||||..|.  .:..:||..||.|.|||:|...:     ..|....:.:.:.
Human    88 SDLAQQYGVRGYPTIKFFRNGD--TASPKEYTAGREADDIVNWLKKR-----TGPAATTLPDGAA 145

  Fly   283 FETACEGKPLCVVSVLPHILDCDAKCRNKFLDTLRTLGEKFKQKQWGWAWAEGGQQLALEESLEV 347
            .|:..|...:.|:.....:....||                             |.|...|:::.
Human   146 AESLVESSEVAVIGFFKDVESDSAK-----------------------------QFLQAAEAIDD 181

  Fly   348 GGFGYPAMA------------VVNFKKMK--FSVLKGSFSKDGINEFLRD------ISYGRGHTA 392
            ..||..:.:            ||.|||..  .:..:|..:|:.:.:|::.      |.:.. .||
Human   182 IPFGITSNSDVFSKYQLDKDGVVLFKKFDEGRNNFEGEVTKENLLDFIKHNQLPLVIEFTE-QTA 245

  Fly   393 P--VRGAKKPAIV-----SVDPWDGK 411
            |  ..|..|..|:     ||..:|||
Human   246 PKIFGGEIKTHILLFLPKSVSDYDGK 271

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CaBP1	NP_001285979.1	PDI_a_P5	26..119	CDD:239299
		PDI_a_P5	157..262	CDD:239299	53/107 (50%)
		Thioredoxin_6	190..383	CDD:290560	56/209 (27%)
		P5_C	271..400	CDD:239281	24/150 (16%)
P4HB	XP_024306545.1	YbbN	24..394	CDD:331940	85/286 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910