DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CaBP1 and Pdia5

DIOPT Version :9

Sequence 1:	NP_001285979.1	Gene:	CaBP1 / 34976	FlyBaseID:	FBgn0025678	Length:	433	Species:	Drosophila melanogaster
Sequence 2:	NP_001014147.1	Gene:	Pdia5 / 360722	RGDID:	1359236	Length:	517	Species:	Rattus norvegicus

Alignment Length:	426	Identity:	101/426 - (23%)
Similarity:	173/426 - (40%)	Gaps:	92/426 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 AFVVGSVSAFYSPSDG------------VVEL-TPSNFDREVLKDDAIWVVEFYAPWCGHCQSLV 62
            |..:.|:.||.....|            ||.: :..:|.|.:.|::...::.||||||..|:.::
  Rat   123 AVTLKSIVAFLKDPKGPPLWEEDPGAKDVVHIDSEKDFRRLLKKEEKPLLMMFYAPWCSMCKRIM 187

  Fly    63 PEYKKLAKALKGVVKVGSVNA--DADSTLSGQFGVRGFPTIKIF------------GANKKSPTD 113
            |.::|.|..::|...:..:|.  .....:..::.|||:|||..|            |:..:...:
  Rat   188 PHFQKAATQVRGHTVLAGMNVYPPEFENIKEEYNVRGYPTICYFEKGRFLFQYENYGSTAEDIVE 252

  Fly   114 Y--NGQRTAKAIAEAALAEVKKKVQGVLGGGGGSSSGGSGSSSGDDVIELTEDNFDKLVLNSDDI 176
            :  |.|.....:.|...|:                .|||       |..||:::||:.|.....:
  Rat   253 WLKNPQPPQPQVPETPWAD----------------EGGS-------VYHLTDEDFDQFVKEHSSV 294

  Fly   177 WLVEFFAPWCGHCKNLAPEWAKAAKELKGKVK----LGALDATAHQSKAAEYNVRGYPTIKFFPA 237
             ||.|.||||||||.:.||:..||:.|.|..:    |.|:|||.:::.|..:::..:||:|:|..
  Rat   295 -LVMFHAPWCGHCKKMKPEFESAAEVLHGDAESSGVLAAVDATINEALAERFHISAFPTLKYFKN 358

  Fly   238 GSKRASDAQEYDGGRTASDIVSWASDKHVANVPAP-------ELIEIINESTFETACEGKPLCVV 295
            |.::|..|.     ||....:.|..:......|.|       .::.::.::..||..:.|...|:
  Rat   359 GEQQAVPAL-----RTKKKFIEWMQNPEAPPPPEPTWEEQQTSVLHLVGDNFRETLKKKKHTLVM 418

  Fly   296 SVLPHILDCDAKCRNKFLDTLRTLGEKFKQKQWGWAWA-----EGGQQLALEESLEVGGFGYPAM 355
            ...|....|     .|.:.......:.||..:.....|     :..|.|..:||::    .||..
  Rat   419 FYAPWCPHC-----KKVIPHFTATADAFKDDRKIACAAVDCVKDKNQDLCQQESVK----AYPTF 474

  Fly   356 AVVNFKKMKFSVLKGSFSKD----GINEFLRDISYG 387
            ...::.|     |...:..|    |...|:|.:..|
  Rat   475 HYYHYGK-----LVEKYESDRTELGFTSFIRTLREG 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CaBP1	NP_001285979.1	PDI_a_P5	26..119	CDD:239299	28/121 (23%)
		PDI_a_P5	157..262	CDD:239299	39/108 (36%)
		Thioredoxin_6	190..383	CDD:290560	46/212 (22%)
		P5_C	271..400	CDD:239281	24/133 (18%)
Pdia5	NP_001014147.1	PDI_b_PDIR_N	26..137	CDD:239365	4/13 (31%)
		PDI_a_PDIR	150..254	CDD:239295	25/103 (24%)
		ER_PDI_fam	166..501	CDD:273457	90/377 (24%)
		PDI_a_PDIR	275..377	CDD:239295	39/114 (34%)
		PDI_a_PDIR	396..499	CDD:239295	20/116 (17%)
		Prevents secretion from ER. /evidence=ECO:0000255	514..517
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0191
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810