DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CaBP1 and pdia6

DIOPT Version :9

Sequence 1:	NP_001285979.1	Gene:	CaBP1 / 34976	FlyBaseID:	FBgn0025678	Length:	433	Species:	Drosophila melanogaster
Sequence 2:	NP_922915.2	Gene:	pdia6 / 322160	ZFINID:	ZDB-GENE-030131-879	Length:	440	Species:	Danio rerio

Alignment Length:	444	Identity:	253/444 - (56%)
Similarity:	322/444 - (72%)	Gaps:	15/444 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MRQLASILLLAFVVGSVSAFYSPSDGVVELTPSNFDREVLKDDAIWVVEFYAPWCGHCQSLVPEY 65
            ||.|..:|..:..|.|....|:.||.||||.||||:|||::.|::|:|||||||||||:||.||:
Zfish     1 MRALLGVLACSLTVLSAYGLYTSSDDVVELNPSNFNREVIQSDSLWLVEFYAPWCGHCKSLAPEW 65

  Fly    66 KKLAKALKGVVKVGSVNADADSTLSGQFGVRGFPTIKIFGANKKSPTDYNGQRTAKAIAEAALAE 130
            ||.|.||||:||||:|:||..::|.||:||||||||||||.||..|.||.|.||.:||.:|||..
Zfish    66 KKAATALKGIVKVGAVDADQHNSLGGQYGVRGFPTIKIFGGNKHKPEDYQGGRTNQAIVDAALNA 130

  Fly   131 VKKKVQGVLGG--GGGSSSGGSGSSSGD--DVIELTEDNFDKLVLNSDDIWLVEFFAPWCGHCKN 191
            ::..|:..|||  ||...|..||..:|:  ||:|||:||||:.||.|||:|||||||||||||||
Zfish   131 LRSLVKDRLGGKTGGSDYSRQSGGGAGNKKDVVELTDDNFDRTVLESDDVWLVEFFAPWCGHCKN 195

  Fly   192 LAPEWAKAAKEL----KGKVKLGALDATAHQSKAAEYNVRGYPTIKFFPAGSKRASDAQEYDGGR 252
            |.|||..||.|:    ||||:|.|.|||.||..|:.:.:||:||||.|    ::..:.::|.|||
Zfish   196 LEPEWTAAATEVKEQTKGKVRLAAEDATVHQGLASRFGIRGFPTIKVF----RKGEEPEDYQGGR 256

  Fly   253 TASDIVSWASDKHVANVPAPELIEIINESTFETACEGKPLCVVSVLPHILDCDAKCRNKFLDTLR 317
            |.||||:.|.:.:..|:|||||.|::||...:..||...||:::|||||||..|..||.:|:.::
Zfish   257 TRSDIVARALELYSDNIPAPELQEVLNEGILKKTCEDYQLCIIAVLPHILDTGASGRNSYLEVMK 321

  Fly   318 TLGEKFKQKQWGWAWAEGGQQLALEESLEVGGFGYPAMAVVNFKKMKFSVLKGSFSKDGINEFLR 382
            |:.||.|:|.|||.|.|.|.|:.||.||.:|||||||||.:|.:||||::||||||:.||:||||
Zfish   322 TMAEKHKKKMWGWLWTEAGAQMELEASLGIGGFGYPAMAAINSRKMKFALLKGSFSETGIHEFLR 386

  Fly   383 DISYGRGHTAPVRGAKKPAIVSVDPWDGKDGQLPTEEDIDLSDIDLD---KDEL 433
            ::|.|||.||.|.|...|.|.:|..||||||:||.|:||||||:|||   ||||
Zfish   387 ELSVGRGSTATVGGGALPKINTVQAWDGKDGELPMEDDIDLSDVDLDDLEKDEL 440

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CaBP1	NP_001285979.1	PDI_a_P5	26..119	CDD:239299	63/92 (68%)
		PDI_a_P5	157..262	CDD:239299	64/108 (59%)
		Thioredoxin_6	190..383	CDD:290560	103/196 (53%)
		P5_C	271..400	CDD:239281	72/128 (56%)
pdia6	NP_922915.2	ER_PDI_fam	25..262	CDD:273457	143/240 (60%)
		PDI_a_P5	26..128	CDD:239299	68/101 (67%)
		PDI_a_P5	161..266	CDD:239299	64/108 (59%)
		P5_C	275..404	CDD:239281	72/128 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594880
Domainoid	1	1.000	216	1.000	Domainoid score	I2649
eggNOG	1	0.900	-	-		E2759_KOG0191
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4198
Inparanoid	1	1.050	524	1.000	Inparanoid score	I1212
OMA	1	1.010	-	-		QHG58248
OrthoDB	1	1.010	-	-		D290413at33208
OrthoFinder	1	1.000	-	-		FOG0000934
OrthoInspector	1	1.000	-	-		oto39441
orthoMCL	1	0.900	-	-		OOG6_100473
Panther	1	1.100	-	-	LDO	PTHR45815
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2193
SonicParanoid	1	1.000	-	-		X1799
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	17	16.800