DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CaBP1 and Dnajc10

DIOPT Version :9

Sequence 1:	NP_001285979.1	Gene:	CaBP1 / 34976	FlyBaseID:	FBgn0025678	Length:	433	Species:	Drosophila melanogaster
Sequence 2:	NP_001099956.2	Gene:	Dnajc10 / 295690	RGDID:	1307813	Length:	793	Species:	Rattus norvegicus

Alignment Length:	440	Identity:	113/440 - (25%)
Similarity:	190/440 - (43%)	Gaps:	104/440 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LLAFVVGSVSAFYSPSDGVVELTPSNFDREVLKDDAIWVVEFYAPWCGHCQSLVPEYKKLAKALK 73
            :|||...||::.      |..|.|.||.   ..|...|:|:|:||||..|::|:||.:|.:..|.
  Rat   443 ILAFAKESVNSH------VTTLGPQNFP---ASDKEPWLVDFFAPWCPPCRALLPELRKASTLLY 498

  Fly    74 GVVKVGSVNADADSTLSGQFGVRGFPTIKIFGANKKSPTDYNGQRTAKAIAEAALAEVKKKVQGV 138
            |.:|||:::......|...:.::.:||..:|  |:.|..:|.|..:|:.|.| .:.:::
  Rat   499 GQLKVGTLDCTIHEGLCNMYNIQAYPTTVVF--NQSSVHEYEGHHSAEQILE-FIEDLR------ 554

  Fly   139 LGGGGGSSSGGSGSSSGDDVIELTEDNFDKLV--LNSDDIWLVEFFAPWCGHCKNLAPEWAKAAK 201
                            ...|:.||...|::||  ...|::|:|:|::|||..|:.|.|||.:.|:
  Rat   555 ----------------NPSVVSLTPTTFNELVKQRKHDEVWMVDFYSPWCHPCQVLMPEWKRMAR 603

  Fly   202 ELKGKVKLGALDATAHQSKAAEYNVRGYPTIKFFPAGSKRASDAQEYDG-GRTASDIVSWASDKH 265
            .|.|.:.:|::|...:.|...:.||:.||.|:|:|..|.||.....|:| .|.|..:.||.
  Rat   604 TLTGLINVGSVDCQQYHSFCTQENVQRYPEIRFYPQKSSRAYQYHSYNGWNRDAYSLRSWG---- 664

  Fly   266 VANVPAPELIEIINESTFETACEGK---------PLCVVSVLPHILDCDAKCRNKFLDTLRTLGE 321
            :..:|... |::..::..|...:||         |.|            ..|:| |......|..
  Rat   665 LGFLPQAS-IDLTPQTFNEKVLQGKTHWVIDFYAPWC------------GPCQN-FAPEFELLAR 715

  Fly   322 KFKQKQWGWAWAEGGQ---QLALEESLEVGGFGYPAMAVVNFKKMKFSVLKGSFSKDGINEFLRD 383
            ..|.|      .:.|:   |...:...:.|...||::.:..:::.|.|:.     ::.||.
  Rat   716 MIKGK------VKAGKVDCQAYPQTCQKAGIRAYPSVKLYLYERAKKSIW-----EEQINS---- 765

  Fly   384 ISYGRGHTAPVRGAKKPAIVSVDPWDGKDGQLPTEEDIDLSDIDLDKDEL 433
                       |.||..|.:..       |:|.|.:    |.:..:||||
  Rat   766 -----------RDAKTIAALIY-------GKLETFQ----SQVKRNKDEL 793

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CaBP1	NP_001285979.1	PDI_a_P5	26..119	CDD:239299	31/92 (34%)
		PDI_a_P5	157..262	CDD:239299	40/107 (37%)
		Thioredoxin_6	190..383	CDD:290560	48/205 (23%)
		P5_C	271..400	CDD:239281	24/140 (17%)
Dnajc10	NP_001099956.2	DnaJ	34..>132	CDD:223560
		DnaJ	35..97	CDD:278647
		PDI_a_ERdj5_N	129..229	CDD:239301
		ER_PDI_fam	130..551	CDD:273457	39/119 (33%)
		Trxb 1	235..350
		Trxb 2	348..463		8/25 (32%)
		PDI_a_ERdj5_C	453..550	CDD:239302	34/108 (31%)
		PDI_a_ERdj5_C	556..663	CDD:239302	38/106 (36%)
		PDI_a_ERdj5_C	670..775	CDD:239302	25/144 (17%)
		Prevents secretion from ER. /evidence=ECO:0000255\|PROSITE-ProRule:PRU10138	790..793		2/2 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0191
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810