DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CaBP1 and pdi-6

DIOPT Version :9

Sequence 1:	NP_001285979.1	Gene:	CaBP1 / 34976	FlyBaseID:	FBgn0025678	Length:	433	Species:	Drosophila melanogaster
Sequence 2:	NP_509190.1	Gene:	pdi-6 / 180974	WormBaseID:	WBGene00015168	Length:	440	Species:	Caenorhabditis elegans

Alignment Length:	439	Identity:	267/439 - (60%)
Similarity:	325/439 - (74%)	Gaps:	10/439 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LASILLLAFVVGSVSAFYSPSDGVVELTPSNFDREVLKDDAIWVVEFYAPWCGHCQSLVPEYKKL 68
            |..:||.:..:.||...||..|.|||||.:||..:|:..|.||:|||||||||||:||||||||.
Worm     3 LIKLLLASLAITSVCGMYSKKDDVVELTEANFQSKVINSDDIWIVEFYAPWCGHCKSLVPEYKKA 67

  Fly    69 AKALKGVVKVGSVNADADSTLSGQFGVRGFPTIKIFGANKKSPTDYNGQRTAKAIAEAALAEVKK 133
            |.|||||.|||:|:.....::.|.:.|:||||:|||||:||.||||||||||:|||::.|||.||
Worm    68 ASALKGVAKVGAVDMTQHQSVGGPYNVQGFPTLKIFGADKKKPTDYNGQRTAQAIADSVLAEAKK 132

  Fly   134 KVQGVLGG-GGGSSSGGSGS--------SSGDDVIELTEDNFDKLVLNSDDIWLVEFFAPWCGHC 189
            .|...||| ..||||.||||        .||::|:|||:.||:.|||||.|||||||||||||||
Worm   133 AVSARLGGKSSGSSSSGSGSGSGKRGGGGSGNEVVELTDANFEDLVLNSKDIWLVEFFAPWCGHC 197

  Fly   190 KNLAPEWAKAAKELKGKVKLGALDATAHQSKAAEYNVRGYPTIKFFPAGSKRASDAQEYDGGRTA 254
            |:|.|:|..||.||||||:|||||||.|...|.::.:||:||||:|..||. .||||:|||||.:
Worm   198 KSLEPQWKAAASELKGKVRLGALDATVHTVVANKFAIRGFPTIKYFAPGSD-VSDAQDYDGGRQS 261

  Fly   255 SDIVSWASDKHVANVPAPELIEIINESTFETACEGKPLCVVSVLPHILDCDAKCRNKFLDTLRTL 319
            ||||:|||.:...|:||||:.|.||:...|.||:.|.||:.:.|||||||.::|||.:|..|:..
Worm   262 SDIVAWASARAQENMPAPEVFEGINQQVVEDACKEKQLCIFAFLPHILDCQSECRNNYLAMLKEQ 326

  Fly   320 GEKFKQKQWGWAWAEGGQQLALEESLEVGGFGYPAMAVVNFKKMKFSVLKGSFSKDGINEFLRDI 384
            .||||:..|||.|.||..|.|||||.||||||||||..:||:|.|::||||||.||||:|||||:
Worm   327 SEKFKKNLWGWIWVEGAAQPALEESFEVGGFGYPAMTALNFRKNKYAVLKGSFGKDGIHEFLRDL 391

  Fly   385 SYGRGHTAPVRGAKKPAIVSVDPWDGKDGQLPTEEDIDLSDIDLDKDEL 433
            |||:|.|:.:||...|.|...:.||||||.||.|:|||||||||||.||
Worm   392 SYGKGRTSSLRGDGFPKIQKTEKWDGKDGALPAEDDIDLSDIDLDKTEL 440

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CaBP1	NP_001285979.1	PDI_a_P5	26..119	CDD:239299	60/92 (65%)
		PDI_a_P5	157..262	CDD:239299	70/104 (67%)
		Thioredoxin_6	190..383	CDD:290560	115/192 (60%)
		P5_C	271..400	CDD:239281	76/128 (59%)
pdi-6	NP_509190.1	PDI_a_P5	25..127	CDD:239299	66/101 (65%)
		PDI_a_P5	165..269	CDD:239299	70/104 (67%)
		P5_C	278..407	CDD:239281	76/128 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166433
Domainoid	1	1.000	223	1.000	Domainoid score	I1462
eggNOG	1	0.900	-	-		E2759_KOG0191
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4198
Inparanoid	1	1.050	552	1.000	Inparanoid score	I615
Isobase	1	0.950	-	0	Normalized mean entropy	S1409
OMA	1	1.010	-	-		QHG58248
OrthoDB	1	1.010	-	-		D290413at33208
OrthoFinder	1	1.000	-	-		FOG0000934
OrthoInspector	1	1.000	-	-		oto18384
orthoMCL	1	0.900	-	-		OOG6_100473
Panther	1	1.100	-	-	LDO	PTHR45815
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2193
SonicParanoid	1	1.000	-	-		X1799
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	17	16.750