DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CaBP1 and ERP27

DIOPT Version :9

Sequence 1:	NP_001285979.1	Gene:	CaBP1 / 34976	FlyBaseID:	FBgn0025678	Length:	433	Species:	Drosophila melanogaster
Sequence 2:	NP_689534.1	Gene:	ERP27 / 121506	HGNCID:	26495	Length:	273	Species:	Homo sapiens

Alignment Length:	326	Identity:	63/326 - (19%)
Similarity:	103/326 - (31%)	Gaps:	127/326 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   119 TAKAIAEAALAEVKKKVQGVLGGGGGSSSGGSGSSSGDDVIELTEDNFDKLVLNSDDIWL----- 178
            |.:..||.| |||:|            ||.|.|::                   .:..||
Human    16 TCELAAEVA-AEVEK------------SSDGPGAA-------------------QEPTWLTDVPA 48

  Fly   179 -VEFFAPW----CGHCKNL----APEWAKAAKELKGKVKLGALDATAHQSKAAEYNVRGYPTIKF 234
             :||.|..    .|..::|    .|......::..| |..|   .:........||:.| .||..
Human    49 AMEFIAATEVAVIGFFQDLEIPAVPILHSMVQKFPG-VSFG---ISTDSEVLTHYNITG-NTICL 108

  Fly   235 FPAGSKRASDAQEYDGGRTASDIVSWASDKHVANVPAPELIEIINESTFETACEGKPLCVV---- 295
            |     |..|.::.:           ..|:.:.::.|.:|...|..::.....|..|:.|:
Human   109 F-----RLVDNEQLN-----------LEDEDIESIDATKLSRFIEINSLHMVTEYNPVTVIGLFN 157

  Fly   296 SVLP-HILDCDAKCRNKFLDTLRTLGEKFKQKQWGWAWAEGGQQL--ALEESLEVGGFGYPAMAV 357
            ||:. |:|....|...::.:.:....:..|..|        |:.|  .::..::..|      .|
Human   158 SVIQIHLLLIMNKASPEYEENMHRYQKAAKLFQ--------GKILFILVDSGMKENG------KV 208

  Fly   358 VNFKKMKFSVLKGSFSKDGINEFLRDISYGRGHTAPVRGAKKPAIVSV----DPWDGKDGQLPTE 418
            ::|.|:|.|.|                               ||:...    |.||    .|||.
Human   209 ISFFKLKESQL-------------------------------PALAIYQTLDDEWD----TLPTA 238

  Fly   419 E 419
            |
Human   239 E 239

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CaBP1	NP_001285979.1	PDI_a_P5	26..119	CDD:239299	63/326 (19%)
		PDI_a_P5	157..262	CDD:239299	19/118 (16%)
		Thioredoxin_6	190..383	CDD:290560	36/203 (18%)
		P5_C	271..400	CDD:239281	22/135 (16%)
ERP27	NP_689534.1	Thioredoxin_6	64..250	CDD:372755	45/246 (18%)
		PDIA3-binding site. /evidence=ECO:0000269\|PubMed:16940051	230..233		1/2 (50%)
		Prevents secretion from ER. /evidence=ECO:0000305\|PubMed:16940051	270..273
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0191
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900