DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CaBP1 and Pdia4

DIOPT Version :9

Sequence 1:	NP_001285979.1	Gene:	CaBP1 / 34976	FlyBaseID:	FBgn0025678	Length:	433	Species:	Drosophila melanogaster
Sequence 2:	NP_446301.2	Gene:	Pdia4 / 116598	RGDID:	619835	Length:	643	Species:	Rattus norvegicus

Alignment Length:	412	Identity:	132/412 - (32%)
Similarity:	194/412 - (47%)	Gaps:	81/412 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 DGVVELTPSNFDREVLKDDAIWVVEFYAPWCGHCQSLVPEYKKLAKALKG---VVKVGSVNADAD 86
            :||..|...|||..|...|.: ::||||||||||:...|||:|:|..||.   .:.|..::|.:.
  Rat    60 NGVWVLNDENFDNFVADKDTV-LLEFYAPWCGHCKQFAPEYEKIASTLKDNDPPIAVAKIDATSA 123

  Fly    87 STLSGQFGVRGFPTIKIFGANKKSPTDYNGQRTAKAIAEAALAEVKKKVQGVLGGGGGSSSGGSG 151
            |.|:.:|.|.|:|||||.  .|....||:|.||.:        |:..||:.|        |....
  Rat   124 SMLASKFDVSGYPTIKIL--KKGQAVDYDGSRTQE--------EIVAKVREV--------SQPDW 170

  Fly   152 SSSGDDVIELTEDNFDKLVLNSDDIWLVEFFAPWCGHCKNLAPEWAKAAKELKGK---VKLGALD 213
            :...:..:.||::|||. |:|:.||.||||:||||||||.||||:.||||||..:   :.|..:|
  Rat   171 TPPPEVTLTLTKENFDD-VVNNADIILVEFYAPWCGHCKKLAPEYEKAAKELSKRSPPIPLAKVD 234

  Fly   214 ATAHQSKAAEYNVRGYPTIKFFPAGSKRASDAQEYDGGRTASDIVSWASDKHVANVPAPELIEII 278
            ||.....|..::|.||||:|.|..|  |..|   |:|.|....||.:..::  :..|:.|::.:
  Rat   235 ATEQTDLAKRFDVSGYPTLKIFRKG--RPFD---YNGPREKYGIVDYMVEQ--SGPPSKEILTL- 291

  Fly   279 NESTFETACEGKPLCVVSVL-----PHIL---DCDAKCRN--KFLDTLRTLGEKFKQKQWGWAWA 333
             :...|...:|..:.::.|.     |..|   |.....|.  ||..|..|...||.:...|
  Rat   292 -KQVQEFLKDGDDVVILGVFQGVGDPGYLQYQDAANTLREDYKFHHTFSTEIAKFLKVSLG---- 351

  Fly   334 EGGQQLALEESLEVGGFGYPAMAVVNFKKMKFSVLKGSFSKDGINEFLRDISYGRGHTAPVRG-- 396
                :|.|.:..:......|.|.|::        ::||.....|.:::..      |..|:.|
  Rat   352 ----KLVLMQPEKFQSKYEPRMHVMD--------VQGSTEASAIKDYVVK------HALPLVGHR 398

  Fly   397 ---------AKKPAIV---SVD 406
                     :|:|.:|   |||
  Rat   399 KTSNDAKRYSKRPLVVVYYSVD 420

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CaBP1	NP_001285979.1	PDI_a_P5	26..119	CDD:239299	41/95 (43%)
		PDI_a_P5	157..262	CDD:239299	51/107 (48%)
		Thioredoxin_6	190..383	CDD:290560	55/205 (27%)
		P5_C	271..400	CDD:239281	27/149 (18%)
Pdia4	NP_446301.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	24..58
		pdi_dom	65..166	CDD:273454	45/119 (38%)
		CXXC. /evidence=ECO:0000250\|UniProtKB:P08003	89..92		2/2 (100%)
		ER_PDI_fam	175..635	CDD:273457	84/278 (30%)
		CXXC. /evidence=ECO:0000250\|UniProtKB:P08003	553..556
		Prevents secretion from ER	640..643
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910