DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CaBP1 and Txndc5

DIOPT Version :9

Sequence 1:	NP_001285979.1	Gene:	CaBP1 / 34976	FlyBaseID:	FBgn0025678	Length:	433	Species:	Drosophila melanogaster
Sequence 2:	NP_001258259.1	Gene:	Txndc5 / 100362805	RGDID:	2323973	Length:	417	Species:	Rattus norvegicus

Alignment Length:	250	Identity:	85/250 - (34%)
Similarity:	133/250 - (53%)	Gaps:	32/250 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 GVVELTPSNFDREVLKDDAIWVVEFYAPWCGHCQSLVPEYKKLAKALK--GVVKVGSVNADADST 88
            |:.||:.:||:..|.:.:..  ::|:|||||||::|.|.:::||..|:  ..||:|.|:......
  Rat   176 GLYELSANNFELHVSQGNHF--IKFFAPWCGHCKALAPTWEQLALGLEHSETVKIGKVDCTQHYA 238

  Fly    89 LSGQFGVRGFPTIKIFGANKKSPTDYNGQRTAKAI----------AEAALAEVKKKVQGVLGGGG 143
            :..:..|||:||:..|...|| ...|.|:|..:::          :|||...|:.....||   .
  Rat   239 VCSEHQVRGYPTLLWFRDGKK-VDQYKGKRDLESLRDYVQSQLQGSEAAPETVEPSEAPVL---A 299

  Fly   144 GSSSGGSGSSSGDDVIELTEDNFDKLVLNSDDIWLVEFFAPWCGHCKNLAPEWAK-AAKELKG-- 205
            ....|..|:     |:.|||.:|:..:  :..|..|:|:||||||||||||.|.: :.||..|
  Rat   300 AEPPGDKGT-----VLALTEKSFEDTI--AQGITFVKFYAPWCGHCKNLAPTWEELSKKEFPGLA 357

  Fly   206 KVKLGALDATAHQSKAAEYNVRGYPTIKFFPAGSKRASDAQEYDGGRTASDIVSW 260
            .|.:..:|.||.:...::|:||||||:..|..|.|    ..|::|||....:.|:
  Rat   358 DVTIAEVDCTAERGVCSKYSVRGYPTLLLFRGGEK----VGEHNGGRDLDSLHSF 408

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CaBP1	NP_001285979.1	PDI_a_P5	26..119	CDD:239299	33/94 (35%)
		PDI_a_P5	157..262	CDD:239299	43/106 (41%)
		Thioredoxin_6	190..383	CDD:290560	28/73 (38%)
		P5_C	271..400	CDD:239281
Txndc5	NP_001258259.1	PDI_a_ERp46	47..150	CDD:239303
		ER_PDI_fam	52..417	CDD:273457	85/249 (34%)
		PDI_a_ERp46	176..276	CDD:239303	34/102 (33%)
		PDI_a_ERp46	308..409	CDD:239303	43/111 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0191
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000934
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810