DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment chif and DBF4

DIOPT Version :9

Sequence 1:	NP_523583.2	Gene:	chif / 34974	FlyBaseID:	FBgn0000307	Length:	1711	Species:	Drosophila melanogaster
Sequence 2:	NP_006707.1	Gene:	DBF4 / 10926	HGNCID:	17364	Length:	674	Species:	Homo sapiens

Alignment Length:	708	Identity:	155/708 - (21%)
Similarity:	255/708 - (36%)	Gaps:	242/708 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 PKVKVIKSK--------RPLCHFKFYLDICDHQLAKRIESDIKALGGHLEFFLSDDITHFVTDKP 88
            |.:|.:|:.        :||....||||:....::::::.|||.|||.:|.|||.||::.:::|.
Human    27 PSLKSLKTDNRPEKSKCKPLWGKVFYLDLPSVTISEKLQKDIKDLGGRVEEFLSKDISYLISNKK 91

  Fly    89 E-----VIGGTSGTPGTPST-PGTPTSHYQQNDGSARKPNQRQSRADAILSRVRRSTVGVVNSGN 147
            |     .:|..|..|...|. ....||.:..:|||:.|     |.....|||.:......:...:
Human    92 EAKFAQTLGRISPVPSPESAYTAETTSPHPSHDGSSFK-----SPDTVCLSRGKLLVEKAIKDHD 151

  Fly   148 STPTTSLKRSYTIW-----QTDYAQRFIKRIQTELKQYL----------EGKKEGGGGSTSASPH 197
            ..|:.|:..:...|     ..|..:.:|::.:.||  ||          .||:.|.|...:.:.
Human   152 FIPSNSILSNALSWGVKILHIDDIRYYIEQKKKEL--YLLKKSSTSVRDGGKRVGSGAQKTRTG- 213

  Fly   198 HIQLKKQYVKIESVKRNYRPYYHLIKQPDDWPKIDLSSED--GAFRLLTKSKTKDKEHSMTRKPL 260
              :|||.:||:|.:.:.|||:|   .|..:.|.|:.|.:.  ..|.:       ||..||.::..
Human   214 --RLKKPFVKVEDMSQLYRPFY---LQLTNMPFINYSIQKPCSPFDV-------DKPSSMQKQTQ 266

  Fly   261 GSRTSQKD-KQAAGEAKPLQHPSLQELKKQSAIPNSPRSNCREPIDSSEKQGGVCEICKLEYDIL 324
            .....|.| .:..|.:..||   |:|.||:                      |.||.|..:|:.|
Human   267 VKLRIQTDGDKYGGTSIQLQ---LKEKKKK----------------------GYCECCLQKYEDL 306

  Fly   325 NIHLQSKDHELFAKNSDNFLALDTLIQSSADVNRFLEEEPVESELDMDVDESLSNEELQSPRQRP 389
            ..||.|:.|..||: |:.:..:|.::                |:|..|..|          .::.
Human   307 ETHLLSEQHRNFAQ-SNQYQVVDDIV----------------SKLVFDFVE----------YEKD 344

  Fly   390 SPALREKSKRITKGKHSSEKFQGVAVASPQTPFPGAKKVQGNSPGSLSELQR---QEHPTTAAAT 451
            :|    |.|||   |:|......|:.:.       .||.:......|..:.:   ||..||.
Human   345 TP----KKKRI---KYSVGSLSPVSASV-------LKKTEQKEKVELQHISQKDCQEDDTTV--- 392

  Fly   452 PTTNSGRRKTQNSGLSPPKRAMLPPSSIYKVVETREE----CATPPRGRGRPPNQVDSPSLIVKF 512
                    |.||              .:||..:..|:    .:.|          :..||
Human   393 --------KEQN--------------FLYKETQETEKKLLFISEP----------IPHPS----- 420

  Fly   513 QKIRQTELQRLNGE---------------AENFMFPRTAVPTTRSSSELPTDVDRQTTSD----- 557
                 .||:.||.:               .:||    |.:|..::..|...|:...|.|:
Human   421 -----NELRGLNEKMSNKCSMLSTAEDDIRQNF----TQLPLHKNKQECILDISEHTLSENDLEE 476

  Fly   558 ---------VRGRYSISSASLDTSTSEAETKESSGLPTSIRKRAQAVGRRRKVGGAAAQDVFQRQ 613
                     ::....:|..|.|.|.|:.:.|..:.|                   ..|:|:.::.
Human   477 LRVDHYKCNIQASVHVSDFSTDNSGSQPKQKSDTVL-------------------FPAKDLKEKD 522

  Fly   614 L------STGSSSSNSNQQR--------FPSAPIQPEE------GPQPQPKPQLKIKI 651
            |      .:|..:.||:|:.        |.:.|.:|.|      ...|..|...|:||
Human   523 LHSIFTHDSGLITINSSQEHLTVQAKAPFHTPPEEPNECDFKNMDSLPSGKIHRKVKI 580

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
chif	NP_523583.2	DBF4	<40..350	CDD:227399	89/341 (26%)
chif	NP_523583.2	ZnF_DBF	307..355	CDD:128854	14/47 (30%)
DBF4	NP_006707.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..40		3/12 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	100..131		10/35 (29%)
		zf-DBF	294..336	CDD:322049	16/58 (28%)
		Integrase domain-binding motif 1 (IBM1). /evidence=ECO:0000269\|PubMed:29997176	614..638
		Integrase domain-binding motif 2 (IBM2). /evidence=ECO:0000269\|PubMed:29997176	655..674
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142166
Domainoid	1	1.000	70	1.000	Domainoid score	I9548
eggNOG	1	0.900	-	-		E1_COG5067
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003541
OrthoInspector	1	1.000	-	-		otm40552
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR15375
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4510
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	9	8.830