DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cact and BCL3

DIOPT Version :9

Sequence 1:	NP_001260496.1	Gene:	cact / 34969	FlyBaseID:	FBgn0000250	Length:	500	Species:	Drosophila melanogaster
Sequence 2:	XP_011525500.2	Gene:	BCL3 / 602	HGNCID:	998	Length:	696	Species:	Homo sapiens

Alignment Length:	248	Identity:	82/248 - (33%)
Similarity:	125/248 - (50%)	Gaps:	33/248 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   211 PSSINIMNAWEQFYQQNDDGDTPLHLACISGSVDVVAALIRMAPHPCL-LNIQNDVAQTPLHLAA 274
            |.|.:|..|    .:.::|||||||:|.:.|::..|..|:.:...... |:|.|::.|||||||.
Human   342 PLSADIAMA----TRADEDGDTPLHIAVVQGNLPAVHRLVNLFQQGGRELDIYNNLRQTPLHLAV 402

  Fly   275 LTAQPNIMRILLLAGAEPTVRDRHGNTALHLSCIAGEKQCVRALTEKFGATEIHEAHRQYGHRSN 339
            :|..|:::|:|:.|||.|...||||.||.||:|......|:|||.:
Human   403 ITTLPSVVRLLVTAGASPMALDRHGQTAAHLACEHRSPTCLRALLD------------------- 448

  Fly   340 DKAVSSLSYACLPADLEIRNYDGERCVHLAAEAGHIDILRILVSHGADINAREGKSGRTPLHIAI 404
                   |.|....|||.|||||...:|:|......:.:::|:..||||:|.:.||||:||..|:
Human   449 -------SAAPGTLDLEARNYDGLTALHVAVNTECQETVQLLLERGADIDAVDIKSGRSPLIHAV 506

  Fly   405 EGCNEDLANFLLDECEKLNLETATYAGLTAYQFACIMNKSRMQNILEKRGAET 457
            |..:..:...||.....:|.:  .|:|.:|...|.......:...|.:.||::
Human   507 ENNSLSMVQLLLQHGANVNAQ--MYSGSSALHSASGRGLLPLVRTLVRSGADS 557

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cact	NP_001260496.1	ANK	<225..286	CDD:238125	24/61 (39%)
		ANK repeat	229..263	CDD:293786	13/34 (38%)
		Ank_4	230..286	CDD:290365	23/56 (41%)
		ANK	260..416	CDD:238125	56/155 (36%)
		ANK repeat	265..296	CDD:293786	15/30 (50%)
		Ank_2	270..391	CDD:289560	42/120 (35%)
		ANK repeat	298..324	CDD:293786	11/25 (44%)
		ANK repeat	361..393	CDD:293786	10/31 (32%)
		Ank_5	381..438	CDD:290568	20/56 (36%)
		ANK repeat	395..425	CDD:293786	10/29 (34%)
BCL3	XP_011525500.2	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1341288at2759
OrthoFinder	1	1.000	-	-		FOG0002150
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.920