DRSC/TRiP Functional Genomics Resources

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Protein Alignment cact and NFKBIE

DIOPT Version :10

Sequence 1:NP_476942.1 Gene:cact / 34969 FlyBaseID:FBgn0000250 Length:500 Species:Drosophila melanogaster
Sequence 2:NP_004547.3 Gene:NFKBIE / 4794 HGNCID:7799 Length:361 Species:Homo sapiens


Alignment Length:434 Identity:118/434 - (27%)
Similarity:180/434 - (41%) Gaps:112/434 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    68 PNETSDSGFISGPQSSQIFSEEIVPDSEEQDKDQQESAPQ------KEQPVVLDSGIIDEEEDQE 126
            |:|..:|.:.||.:|  :.|...:|:|        .|||.      ..||.....|.:  :|.||
Human     8 PDEAEESQYDSGIES--LRSLRSLPES--------TSAPASGPSDGSPQPCTHPPGPV--KEPQE 60

  Fly   127 EQEKEEEHQDTTTATADSMRLKHSADTGIPQWTVESHLVSRGEQLNNLGQSSSTQITGRSKVQSS 191
            :::.:.|..|:|                                   .|.||.|.          
Human    61 KEDADGERADST-----------------------------------YGSSSLTY---------- 80

  Fly   192 TASTANANPSGSGATSSAPPSSINIMNA-----WEQFYQQNDDGDTPLHLACISGSVDVVAALIR 251
            |.|..    .|..|...||...:..:.|     .|.....::||||.:|||.|..:..|:...:.
Human    81 TLSLL----GGPEAEDPAPRLPLPHVGALSPQQLEALTYISEDGDTLVHLAVIHEAPAVLLCCLA 141

  Fly   252 MAPHPCLLNIQNDVAQTPLHLAALTAQPNIMRILLLAGAEPTVRDRHGNTALHLSCIAGEKQCVR 316
            :.|.. :|:|||::.||.||||....||..:|.|:|.||...::||||:||||::|......|.|
Human   142 LLPQE-VLDIQNNLYQTALHLAVHLDQPGAVRALVLKGASRALQDRHGDTALHVACQRQHLACAR 205

  Fly   317 ALTEKFGATEIHEAHRQYGHRSNDKAVS-SLSYACLPADLEIRNYDGERCVHLAAEAGHIDILRI 380
            .|.|              |.....:..| ||       ||:::|:.|..|:|:|....:..::.:
Human   206 CLLE--------------GRPEPGRGTSHSL-------DLQLQNWQGLACLHIATLQKNQPLMEL 249

  Fly   381 LVSHGADINAREGKSGRTPLHIAIEGCNEDLANFL-----------LDECEKLNLETATYAGLTA 434
            |:.:||||:.:||.||:|.||:|:|.....|..||           |:.|..|:|.    ||...
Human   250 LLRNGADIDVQEGTSGKTALHLAVETQERGLVQFLLQAGAQVDARMLNGCTPLHLA----AGRGL 310

  Fly   435 YQFACIMNKSRMQNILEKRGAETVTPPDSDYDSSDIEDLDDTKM 478
            ...:..:.|:...::|  |..|..||.|...:|..:...||.|:
Human   311 MGISSTLCKAGADSLL--RNVEDETPQDLTEESLVLLPFDDLKI 352

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cactNP_476942.1 ANKYR <225..464 CDD:440430 81/250 (32%)
ANK repeat 229..263 CDD:293786 12/33 (36%)
ANK repeat 265..296 CDD:293786 13/30 (43%)
ANK repeat 298..324 CDD:293786 11/25 (44%)
ANK repeat 361..393 CDD:293786 9/31 (29%)
ANK repeat 395..425 CDD:293786 13/40 (33%)
NFKBIENP_004547.3 ANKYR 116..357 CDD:440430 85/265 (32%)
ANK repeat 119..152 CDD:293786 12/33 (36%)
ANK repeat 154..185 CDD:293786 13/30 (43%)
ANK repeat 187..228 CDD:293786 17/61 (28%)
ANK repeat 231..261 CDD:293786 9/29 (31%)
ANK repeat 264..295 CDD:293786 10/30 (33%)
ANK repeat 297..328 CDD:293786 7/36 (19%)

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