DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment cact and NFKBIB

DIOPT Version :9

Sequence 1:NP_001260496.1 Gene:cact / 34969 FlyBaseID:FBgn0000250 Length:500 Species:Drosophila melanogaster
Sequence 2:NP_002494.2 Gene:NFKBIB / 4793 HGNCID:7798 Length:356 Species:Homo sapiens


Alignment Length:309 Identity:90/309 - (29%)
Similarity:130/309 - (42%) Gaps:36/309 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly   198 ANPSGSGATSSAPPSSINIMNAWEQ--FYQQNDDGDTPLHLACISGSVDVVAALIRMAPHPCLLN 260
            |.|.|.|..:...|..     :|..  |....:||||.||||.|......:..|:..:.....::
Human    29 AAPGGPGLGAELGPGL-----SWAPLVFGYVTEDGDTALHLAVIHQHEPFLDFLLGFSAGTEYMD 88

  Fly   261 IQNDVAQTPLHLAALTAQPNIMRILLLAGAEPTVRDRHGNTALHLSCIAGEKQCVRALTEKFGAT 325
            :|||:.||.|||||:..:.:.:..|..|||...|.:|.|:|||||:|..|...|.|||.:. ...
Human    89 LQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQP-RPR 152

  Fly   326 EIHEAHRQYGHRSNDKA--VSSLSYACLP----------------ADLEIRNYDGERCVHLAAEA 372
            ...||...|..:..|:.  .:....|..|                ..||..||:|...:|:|...
Human   153 RPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAVIH 217

  Fly   373 GHIDILRILVSHGADINAREGKSGRTPLHIAIEGCNEDLANFLLDECEKLNLETATYAGLTAYQF 437
            ..::::|:|...|||::..|...||:|||:|:|....|:...||.  ...|.....|.|.|....
Human   218 KDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLR--AGANPAARMYGGRTPLGS 280

  Fly   438 ACIMNKSRMQNILEKRGAETVTPPDSD------YDSSDIEDLDDTKMYD 480
            |.:.....:..:|...||.  .|...|      ..|||.:..|:...||
Human   281 AMLRPNPILARLLRAHGAP--EPEGEDEKSGPCSSSSDSDSGDEGDEYD 327

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cactNP_001260496.1 ANK <225..286 CDD:238125 20/60 (33%)
ANK repeat 229..263 CDD:293786 10/33 (30%)
Ank_4 230..286 CDD:290365 19/55 (35%)
ANK 260..416 CDD:238125 55/173 (32%)
ANK repeat 265..296 CDD:293786 12/30 (40%)
Ank_2 270..391 CDD:289560 41/138 (30%)
ANK repeat 298..324 CDD:293786 12/25 (48%)
ANK repeat 361..393 CDD:293786 8/31 (26%)
Ank_5 381..438 CDD:290568 19/56 (34%)
ANK repeat 395..425 CDD:293786 11/29 (38%)
NFKBIBNP_002494.2 Ank_2 <52..118 CDD:315466 22/65 (34%)
ANK repeat 57..91 CDD:293786 10/33 (30%)
ANK 1 57..86 10/28 (36%)
ANK 88..261 CDD:238125 55/173 (32%)
ANK repeat 93..124 CDD:293786 12/30 (40%)
ANK 2 93..122 11/28 (39%)
ANK 3 126..155 12/29 (41%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 149..193 6/44 (14%)
ANK repeat 206..237 CDD:293786 8/30 (27%)
ANK 4 206..235 8/28 (29%)
ANK repeat 239..271 CDD:293786 11/33 (33%)
ANKYR <240..>299 CDD:223738 17/60 (28%)
ANK 5 240..269 11/30 (37%)
ANK 6 273..302 6/30 (20%)
ANK repeat 273..298 CDD:293786 4/24 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 298..356 9/32 (28%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1341288at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
43.880

Return to query results.
Submit another query.