DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment cact and NFKBIA

DIOPT Version :9

Sequence 1:NP_001260496.1 Gene:cact / 34969 FlyBaseID:FBgn0000250 Length:500 Species:Drosophila melanogaster
Sequence 2:NP_065390.1 Gene:NFKBIA / 4792 HGNCID:7797 Length:317 Species:Homo sapiens


Alignment Length:277 Identity:98/277 - (35%)
Similarity:136/277 - (49%) Gaps:38/277 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly   220 WEQFYQQNDDGDTPLHLACISGSVDVVAALIRMAPHP-CLLNIQNDVAQTPLHLAALTAQPNIMR 283
            |:|  |..:|||:.||||.|.....:...:||..... ..||.||::.|||||||.:|.||.|..
Human    66 WKQ--QLTEDGDSFLHLAIIHEEKALTMEVIRQVKGDLAFLNFQNNLQQTPLHLAVITNQPEIAE 128

  Fly   284 ILLLAGAEPTVRDRHGNTALHLSCIAGEKQCVRALTEKFGATEIHEAHRQYGHRSNDKAVSSLSY 348
            .||.||.:|.:||..|||.|||:|..|....|..||:......:|..                  
Human   129 ALLGAGCDPELRDFRGNTPLHLACEQGCLASVGVLTQSCTTPHLHSI------------------ 175

  Fly   349 ACLPADLEIRNYDGERCVHLAAEAGHIDILRILVSHGADINAREGKSGRTPLHIAIEGCNEDLAN 413
                  |:..||:|..|:|||:..|::.|:.:|||.|||:||:|..:|||.||:|::..|.||.:
Human   176 ------LKATNYNGHTCLHLASIHGYLGIVELLVSLGADVNAQEPCNGRTALHLAVDLQNPDLVS 234

  Fly   414 FLLDECEKLNLETATYAGLTAYQFACIMNKSRMQNILEKRGAET--VTPPDSDYDSSDIED---- 472
            .|| :| ..::...||.|.:.||.......:|:|..|.:...|.  :.|...|.:|.|.|.    
Human   235 LLL-KC-GADVNRVTYQGYSPYQLTWGRPSTRIQQQLGQLTLENLQMLPESEDEESYDTESEFTE 297

  Fly   473 -LDDTKMYDR--FGDPR 486
             .:|...||.  ||..|
Human   298 FTEDELPYDDCVFGGQR 314

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cactNP_001260496.1 ANK <225..286 CDD:238125 26/61 (43%)
ANK repeat 229..263 CDD:293786 12/34 (35%)
Ank_4 230..286 CDD:290365 24/56 (43%)
ANK 260..416 CDD:238125 61/155 (39%)
ANK repeat 265..296 CDD:293786 16/30 (53%)
Ank_2 270..391 CDD:289560 44/120 (37%)
ANK repeat 298..324 CDD:293786 11/25 (44%)
ANK repeat 361..393 CDD:293786 15/31 (48%)
Ank_5 381..438 CDD:290568 26/56 (46%)
ANK repeat 395..425 CDD:293786 12/29 (41%)
NFKBIANP_065390.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..39
Ank_2 <27..>151 CDD:330894 40/86 (47%)
Destruction motif 30..36
Nuclear export signal 45..54
ANK repeat 73..108 CDD:293786 12/34 (35%)
ANK 1 73..103 10/29 (34%)
ANK 105..237 CDD:238125 61/155 (39%)
ANK repeat 110..141 CDD:293786 16/30 (53%)
ANK 2 110..139 16/28 (57%)
Nuclear import signal 110..120 7/9 (78%)
ANK repeat 143..180 CDD:293786 13/60 (22%)
ANK 3 143..172 11/28 (39%)
ANK repeat 182..213 CDD:293786 15/30 (50%)
ANK 4 182..211 13/28 (46%)
ANK repeat 216..246 CDD:293786 12/31 (39%)
ANK 5 216..245 12/30 (40%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165156345
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E33208_3BM8A
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H7863
Inparanoid 1 1.050 136 1.000 Inparanoid score I4568
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1341288at2759
OrthoFinder 1 1.000 - - FOG0002150
OrthoInspector 1 1.000 - - oto90651
orthoMCL 1 0.900 - - OOG6_108699
Panther 1 1.100 - - LDO PTHR46680
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
1110.800

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