Protein Alignment cact and NFKB2

DIOPT Version :10

• Sequence 1: NP_476942.1
• Gene: cact / 34969
• FlyBaseID: FBgn0000250
• Length: 500
• Species: Drosophila melanogaster
• Sequence 2: NP_001070962.1
• Gene: NFKB2 / 4791
• HGNCID: 7795
• Length: 900
• Species: Homo sapiens
• Alignment Length: 367
• Identity: 103/367 - (28%)
• Similarity: 161/367 - (43%)
• Gaps: 75/367 - (20%)

  Fly   150 SADTGIPQWTVES-HLVSRGEQLN----NLGQSSSTQITGRSKVQSSTASTANANPSGSGATSSA 209
            ||.:..||...:: .::.|..:.|    .|.|.|:     |:.:.....:.|.|..:|.....:|
Human   424 SAPSRTPQCEPQAPEMLQRAREYNARLFGLAQRSA-----RALLDYGVTADARALLAGQRHLLTA 483

  Fly   210 PPSSINIMNAWEQFYQQNDDGDTPLHLACISGSVDVVAALIRMAPHP---CLLNIQNDVAQTPLH 271
                            |:::||||||||.|.|...|:..::.:..|.   .::|:.|.:.|||||
Human   484 ----------------QDENGDTPLHLAIIHGQTSVIEQIVYVIHHAQDLGVVNLTNHLHQTPLH 532

  Fly   272 LAALTAQPNIMRILLLAGAEPTVRDRHGNTALHLSCIAGEKQCVRALTEKFGATEIHEAHRQYGH 336
            ||.:|.|.:::..||..||:|.:.||||::|:||:..||.           ||.|:..|..|.|
Human   533 LAVITGQTSVVSFLLRVGADPALLDRHGDSAMHLALRAGA-----------GAPELLRALLQSG- 585

  Fly   337 RSNDKAVSSLSYACLPADLEIRNYDGERCVHLAAEAGHIDILRILVSHGADINAREGKSGRTPLH 401
                       ...:|..|.:.:::|...||||..|...:.|.:||..||::.|.|.:.|||.||
Human   586 -----------APAVPQLLHMPDFEGLYPVHLAVRARSPECLDLLVDSGAEVEATERQGGRTALH 639

  Fly   402 IAIEGCNEDLANFLLDECEKLNLETATYAGLTAYQFACIMNKSRMQNILEKRGAE---------- 456
            :|.|.....|...|:.:. :.|:...|:||.|....|..:....:..:|.|.||:
Human   640 LATEMEELGLVTHLVTKL-RANVNARTFAGNTPLHLAAGLGYPTLTRLLLKAGADIHAENEEPLC 703

  Fly   457 -TVTPPDSDYDSSDIEDLDDTKMYDRFGDPRYFVSYNGGNPM 497
             ..:||.||.||.......||:.           |:.|..|:
Human   704 PLPSPPTSDSDSDSEGPEKDTRS-----------SFRGHTPL 734

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cact	NP_476942.1	ANKYR	<225..464	CDD:440430	80/252 (32%)
		ANK repeat	229..263	CDD:293786	13/36 (36%)
		ANK repeat	265..296	CDD:293786	14/30 (47%)
		ANK repeat	298..324	CDD:293786	7/25 (28%)
		ANK repeat	361..393	CDD:293786	12/31 (39%)
		ANK repeat	395..425	CDD:293786	10/29 (34%)
NFKB2	NP_001070962.1	RHD-n_NFkB2	38..221	CDD:143650
		IPT_NFkappaB	228..327	CDD:238582
		Nuclear localization signal. /evidence=ECO:0000255	337..341
		GRR	346..377
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	404..435		4/10 (40%)
		ANKYR	438..706	CDD:440430	88/312 (28%)
		ANK repeat	487..524	CDD:293786	13/36 (36%)
		ANK 1	487..519		12/31 (39%)
		ANK repeat	526..557	CDD:293786	14/30 (47%)
		ANK 2	526..555		14/28 (50%)
		ANK 3	559..591		13/54 (24%)
		ANK repeat	559..586	CDD:293786	13/49 (27%)
		ANK repeat	599..630	CDD:293786	12/30 (40%)
		ANK 4	599..628		11/28 (39%)
		ANK repeat	633..665	CDD:293786	10/32 (31%)
		ANK 5	633..663		10/30 (33%)
		ANK repeat	667..698	CDD:293786	8/30 (27%)
		ANK 6	667..696		8/28 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	698..734		10/46 (22%)
		ANK 7	729..758		2/6 (33%)
		Death_NFkB2_p100	774..849	CDD:176776
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	849..900