DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cact and nfkbiaa

DIOPT Version :9

Sequence 1:	NP_001260496.1	Gene:	cact / 34969	FlyBaseID:	FBgn0000250	Length:	500	Species:	Drosophila melanogaster
Sequence 2:	NP_998349.2	Gene:	nfkbiaa / 406463	ZFINID:	ZDB-GENE-040426-2227	Length:	310	Species:	Danio rerio

Alignment Length:	386	Identity:	109/386 - (28%)
Similarity:	157/386 - (40%)	Gaps:	104/386 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   100 DQQESAPQKEQPVV--LDSGIID-EEEDQEEQEKEEEHQDTTTATADSMRLKHSADTGIPQWTVE 161
            |:.::..:|.|...  :|||:.. :||:.|.:|..||.:..|.|:     ||.:
Zfish    17 DEMDTKNRKTQQCEDRVDSGVDSLKEEEYETREISEEMEKLTIAS-----LKET----------- 65

  Fly   162 SHLVSRGEQLNNLGQSSSTQITGRSKVQSSTASTANANPSGSGATSSAPPSSINIMNAWEQFYQQ 226
                                                                  |...|.:..
Zfish    66 ------------------------------------------------------ICEPWAKVV-- 74

  Fly   227 NDDGDTPLHLACISGSVDVVAALIRMAPHPCLLNIQNDVAQTPLHLAALTAQPNIMRILLLAGAE 291
            .:||||.||||.|..:.|....:|:...:...||.||:..||.||||.:|.||.::..||.||.:
Zfish    75 TEDGDTYLHLAIIHEAEDYAVQIIKQCQNDPYLNRQNNQRQTALHLAVVTEQPQMVERLLKAGCD 139

  Fly   292 PTVRDRHGNTALHLSCIAGEKQCVRALTEKFGATEIHEAHRQYGHRSNDKAVSSLSYACLPADLE 356
            |.:.|:.|||||||:|..|...|...|      |:|...|                   |.:.|.
Zfish   140 PQLVDQSGNTALHLACKQGSLACFSVL------TQIQTQH-------------------LRSILT 179

  Fly   357 IRNYDGERCVHLAAEAGHIDILRILVSHGADINAREGKSGRTPLHIAIEGCNEDLANFLLDECEK 421
            ..||.|..|:|:||...::.::..||..|||::|:|..||||.||:|::..|.||.:.|:.....
Zfish   180 FPNYSGHTCLHIAAINNYLSMVESLVQLGADVDAKEQCSGRTSLHLAVDLQNLDLVHTLIALGAD 244

  Fly   422 LNLETATYAGLTAYQFACIMNKSRMQNILEKRGA--ETVTPPDSDYDSSDIEDLDDTKMYD 480
            .|  :.||.|.|||......:.|.:|..|..|.|  .||.|.....:|.|....:|..:||
Zfish   245 AN--SLTYGGYTAYHLTFGRHNSEIQRQLYSRTALKFTVMPESESEESEDELMSEDDCIYD 303

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cact	NP_001260496.1	ANK	<225..286	CDD:238125	24/60 (40%)
		ANK repeat	229..263	CDD:293786	13/33 (39%)
		Ank_4	230..286	CDD:290365	23/55 (42%)
		ANK	260..416	CDD:238125	58/155 (37%)
		ANK repeat	265..296	CDD:293786	14/30 (47%)
		Ank_2	270..391	CDD:289560	41/120 (34%)
		ANK repeat	298..324	CDD:293786	11/25 (44%)
		ANK repeat	361..393	CDD:293786	11/31 (35%)
		Ank_5	381..438	CDD:290568	25/56 (45%)
		ANK repeat	395..425	CDD:293786	12/29 (41%)
nfkbiaa	NP_998349.2	ANK repeat	77..111	CDD:293786	13/33 (39%)
		Ank_4	78..134	CDD:290365	23/55 (42%)
		ANK	108..239	CDD:238125	58/155 (37%)
		ANK repeat	115..144	CDD:293786	14/28 (50%)
		Ank_2	118..214	CDD:289560	41/120 (34%)
		ANK repeat	146..182	CDD:293786	16/60 (27%)
		ANK repeat	184..214	CDD:293786	10/29 (34%)
		Ank_5	204..258	CDD:290568	25/55 (45%)
		ANK repeat	218..246	CDD:293786	11/27 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591950
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BM8A
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7863
Inparanoid	1	1.050	133	1.000	Inparanoid score	I4579
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1341288at2759
OrthoFinder	1	1.000	-	-		FOG0002150
OrthoInspector	1	1.000	-	-		otm24396
orthoMCL	1	0.900	-	-		OOG6_108699
Panther	1	1.100	-	-	O	PTHR46680
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4493
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.830