DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cact and nfkbiab

DIOPT Version :9

Sequence 1:	NP_001260496.1	Gene:	cact / 34969	FlyBaseID:	FBgn0000250	Length:	500	Species:	Drosophila melanogaster
Sequence 2:	NP_955923.1	Gene:	nfkbiab / 323099	ZFINID:	ZDB-GENE-030131-1819	Length:	312	Species:	Danio rerio

Alignment Length:	274	Identity:	92/274 - (33%)
Similarity:	143/274 - (52%)	Gaps:	44/274 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   220 WEQFYQQNDDGDTPLHLACISGSVDVVAALIRMAPHPCLLNIQNDVAQTPLHLAALTAQPNIMRI 284
            |::  :..:||||.||||.|..:.|....:|.::.....|||||:..||.||||.:|.||.|:..
Zfish    65 WKK--ELTEDGDTYLHLAIIHEATDAALKMIALSRRDPFLNIQNNQRQTALHLAIITDQPLIVEQ 127

  Fly   285 LLLAGAEPTVRDRHGNTALHLSCIAGEKQCVRALTEKFGATEIHEAHRQYGHRSNDKAVSSLSYA 349
            ||.||.:.::.|.|||||||::|..|...|...||:  |.::         |
Zfish   128 LLKAGCDASLVDDHGNTALHIACRKGSLACFGLLTQ--GCSQ---------H------------- 168

  Fly   350 CLPADLEIRNYDGERCVHLAAEAGHIDILRILVSHGADINAREGKSGRTPLHIAIEGCNEDLANF 414
             |.|.|:..||:|::|:|:.|..|::.:|..|:..||||||:|..:|||.||:|::..|.|:...
Zfish   169 -LSAILQTPNYNGQKCIHVVAIQGYLSLLESLIQLGADINAQEQCNGRTALHLAVDLQNFDMVKL 232

  Fly   415 LLDECEKLNLETATYAGLTAYQFACIMNKSRMQNI-----------LEKRGAETVTPPDSDYD-- 466
            |::  :..::.:.||.|.|.|......:.:.:|.:           |.:..:|.....|.||:
Zfish   233 LIE--KGASVHSVTYGGHTPYHLTYGRSNADIQKVLYELTSPHLRELPESDSEDSEDSDEDYEER 295

  Fly   467 -SSDIEDL-DDTKM 478
             .|::||| ||.|:
Zfish   296 CQSEVEDLYDDIKV 309

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cact	NP_001260496.1	ANK	<225..286	CDD:238125	26/60 (43%)
		ANK repeat	229..263	CDD:293786	14/33 (42%)
		Ank_4	230..286	CDD:290365	25/55 (45%)
		ANK	260..416	CDD:238125	60/155 (39%)
		ANK repeat	265..296	CDD:293786	14/30 (47%)
		Ank_2	270..391	CDD:289560	44/120 (37%)
		ANK repeat	298..324	CDD:293786	12/25 (48%)
		ANK repeat	361..393	CDD:293786	13/31 (42%)
		Ank_5	381..438	CDD:290568	22/56 (39%)
		ANK repeat	395..425	CDD:293786	9/29 (31%)
nfkbiab	NP_955923.1	Ank_2	<68..139	CDD:289560	30/70 (43%)
		ANK repeat	72..106	CDD:293786	14/33 (42%)
		ANK	103..234	CDD:238125	60/155 (39%)
		ANK repeat	110..139	CDD:293786	14/28 (50%)
		Ank_2	113..241	CDD:289560	55/154 (36%)
		ANK repeat	141..210	CDD:293786	32/93 (34%)
		Ank_5	167..221	CDD:290568	25/76 (33%)
		ANK repeat	213..241	CDD:293786	9/29 (31%)
		Ank_2	218..>268	CDD:289560	12/51 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591951
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BM8A
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7863
Inparanoid	1	1.050	133	1.000	Inparanoid score	I4579
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1341288at2759
OrthoFinder	1	1.000	-	-		FOG0002150
OrthoInspector	1	1.000	-	-		otm24396
orthoMCL	1	0.900	-	-		OOG6_108699
Panther	1	1.100	-	-	LDO	PTHR46680
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4493
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.830