DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cact and Nfkbie

DIOPT Version :9

Sequence 1:	NP_001260496.1	Gene:	cact / 34969	FlyBaseID:	FBgn0000250	Length:	500	Species:	Drosophila melanogaster
Sequence 2:	NP_954542.1	Gene:	Nfkbie / 316241	RGDID:	735070	Length:	365	Species:	Rattus norvegicus

Alignment Length:	427	Identity:	117/427 - (27%)
Similarity:	176/427 - (41%)	Gaps:	94/427 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 PNETSDSGFISGPQSSQIFSEEIVPDSEEQDKDQQESAPQ--KEQPVVLDSGIIDEEEDQEEQEK 130
            |:|..||...||.:|.:.......|.:...........||  ...|          :.|:|.:.|
  Rat     8 PDEADDSQCDSGIESLRSLRSLPDPAAAPVSGSSHSGCPQPWSHAP----------KTDKEPEGK 62

  Fly   131 EEEHQDTTTATADSMRLKHSADTGIPQWTVESHLVSRGEQLNNLGQSSSTQITGRSKVQSSTAST 195
            |    |.....|||.....|....:|       |:.|.|                         .
  Rat    63 E----DADGERADSTYASSSLTESLP-------LLERPE-------------------------A 91

  Fly   196 ANANPSGSGATSSAPPSSINIMN--AWEQFYQQNDDGDTPLHLACISGSVDVVAALIRMAPHPCL 258
            .:.||    .|.|:|.|...:::  ..|.....::||||.||||.|..:..|:...:...|.. :
  Rat    92 KDPNP----PTPSSPVSPAGVLSPQQLEALTYISEDGDTLLHLAVIHEAPSVLFCCLAFLPQE-V 151

  Fly   259 LNIQNDVAQTPLHLAALTAQPNIMRILLLAGAEPTVRDRHGNTALHLSCIAGEKQCVRALTEKFG 323
            |:|||::.||.||||....||:::|.|:|.||...::|:||:||||::|......|...|.|
  Rat   152 LDIQNNLYQTALHLAVHLDQPDVVRALVLKGASRILQDQHGDTALHVACQRQNLACACCLLE--- 213

  Fly   324 ATEIHEAHRQYGHRSNDKAVSSLSYACLPADLEIRNYDGERCVHLAAEAGHIDILRILVSHGADI 388
              |..|..||..|               |.||:::|:.|..|:|:|....:..::.:|:.:||||
  Rat   214 --EQPEPGRQPSH---------------PLDLQLKNWQGLACLHIATLQRNQPLIELLLQNGADI 261

  Fly   389 NAREGKSGRTPLHIAIEGCNEDLANFLLD-----ECEKLNLETATYAGLTAYQFACIMNKSRMQN 448
            :|:||.||:|.||:|:|.....|..|||.     :...||       |.|....|.....:.:.:
  Rat   262 DAQEGTSGKTALHLAVETQERSLVQFLLQAGARVDARMLN-------GCTPLHLAAGRGLNSISS 319

  Fly   449 ILEKRGAETV-------TPPDSDYDSSDIEDLDDTKM 478
            .|.:.||:::       ||.|...|.......||.|:
  Rat   320 TLCEAGADSLLLNVEDETPQDLAEDLLSYLPFDDLKI 356

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cact	NP_001260496.1	ANK	<225..286	CDD:238125	24/60 (40%)
		ANK repeat	229..263	CDD:293786	13/33 (39%)
		Ank_4	230..286	CDD:290365	23/55 (42%)
		ANK	260..416	CDD:238125	57/155 (37%)
		ANK repeat	265..296	CDD:293786	13/30 (43%)
		Ank_2	270..391	CDD:289560	40/120 (33%)
		ANK repeat	298..324	CDD:293786	10/25 (40%)
		ANK repeat	361..393	CDD:293786	10/31 (32%)
		Ank_5	381..438	CDD:290568	23/61 (38%)
		ANK repeat	395..425	CDD:293786	13/34 (38%)
Nfkbie	NP_954542.1	Ank_2	<122..189	CDD:423045	28/67 (42%)
		ANK repeat	123..156	CDD:293786	13/33 (39%)
		ANK repeat	160..189	CDD:293786	13/28 (46%)
		Ank_2	163..264	CDD:403870	40/120 (33%)
		ANK repeat	191..232	CDD:293786	18/60 (30%)
		ANK repeat	235..265	CDD:293786	10/29 (34%)
		Ank_2	239..327	CDD:403870	28/94 (30%)
		ANK repeat	268..299	CDD:293786	11/30 (37%)
		ANK repeat	301..335	CDD:293786	7/40 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1341288at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm45834
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920