DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cact and nfki-1

DIOPT Version :9

Sequence 1:	NP_001260496.1	Gene:	cact / 34969	FlyBaseID:	FBgn0000250	Length:	500	Species:	Drosophila melanogaster
Sequence 2:	NP_510540.1	Gene:	nfki-1 / 181625	WormBaseID:	WBGene00007877	Length:	611	Species:	Caenorhabditis elegans

Alignment Length:	446	Identity:	100/446 - (22%)
Similarity:	168/446 - (37%)	Gaps:	103/446 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 SNAANPSSSLATSGKIGGKTQDQTAAINKQKEFAVPNETSDSGF--ISGPQSSQIFSEEIVPDSE 95
            |.:..|.:.|::.| .|..:..|.:          |.|:..|.|  ||...:|::    :.|::.
Worm   213 SASTTPDTVLSSDG-YGSASPPQHS----------PKESLQSPFSDISSADTSRV----LTPENN 262

  Fly    96 EQDKDQQESAPQKEQPVVLDSGIIDEEEDQEEQEKEEE------HQDTTTATADSMRLKHSADTG 154
            |        .|:..|..:|        :...:..|||.      ..|:..::..|.|....|...
Worm   263 E--------LPESLQDFIL--------QYSNQYTKEESIRGRPPSADSGVSSPMSARSAPYASPH 311

  Fly   155 IPQWTVESHLVSRGEQLNNLGQSSSTQITGRSKVQSSTASTANANPSGSGATSSAPPSSINIMNA 219
            :||.|..........|.....::|...||.:.::.:....:..|.......|:
Worm   312 VPQGTCSGPTTPSFNQTRLSPRTSENGITAKQRLNAIIPESDLATGFHWACTT------------ 364

  Fly   220 WEQFYQQND-DGDTPLHLACISGSVDVVAALIRMAPHPC-------------LLNIQNDVAQTPL 270
            |:......| |||||||:......:..:.||       |             :.|:.|:..:|||
Worm   365 WKNVLTNRDADGDTPLHIVAAHNDLGKIYAL-------CETLRKTMNENDDNVFNVSNNFGETPL 422

  Fly   271 HLAALTAQPNIMRILLLAGAEPTVRDRH--GNTALHLSCIAGEKQCVRALTEKFGATEIHEAHRQ 333
            ::|.|.....::..||..||.|..|...  |::.||.:...|....|.||..|   .||..
Worm   423 YVAVLQRSIEVVEYLLELGASPNSRSSRAVGDSPLHFATARGMNNMVEALLSK---REIRV---- 480

  Fly   334 YGHRSNDKAVSSLSYACLPADLEIRNYDGERCVHLAAEAGHIDILRILVSHGADINAREGKSGRT 398
              :.:||...:||..|     :::.....|:..|   :..:..|:.:|:..|||....|..:|:|
Worm   481 --NETNDDGQTSLLCA-----VKMHGMMDEQTQH---KIDNKSIIEMLIKAGADPTIAETSTGKT 535

  Fly   399 PLHIAIEGCNEDLANFL---LDE---CEKLNLETATYAGLTAYQFACIMNKSRMQN 448
            .:|.|::..:.:|.:||   ::|   .|..||  :.:.|.||....|    |..||
Worm   536 IVHHAVDKMDVELLDFLKTVVNEDTFTELANL--SDFHGDTAVDLLC----SSTQN 585

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cact	NP_001260496.1	ANK	<225..286	CDD:238125	18/74 (24%)
		ANK repeat	229..263	CDD:293786	11/46 (24%)
		Ank_4	230..286	CDD:290365	16/68 (24%)
		ANK	260..416	CDD:238125	43/160 (27%)
		ANK repeat	265..296	CDD:293786	10/30 (33%)
		Ank_2	270..391	CDD:289560	31/122 (25%)
		ANK repeat	298..324	CDD:293786	8/27 (30%)
		ANK repeat	361..393	CDD:293786	7/31 (23%)
		Ank_5	381..438	CDD:290568	19/62 (31%)
		ANK repeat	395..425	CDD:293786	10/35 (29%)
nfki-1	NP_510540.1	Ank_2	<372..447	CDD:315466	23/81 (28%)
		ANK repeat	375..415	CDD:293786	11/46 (24%)
		ANK	412..552	CDD:238125	41/156 (26%)
		ANK repeat	417..448	CDD:293786	10/30 (33%)
		ANK repeat	486..527	CDD:293786	10/48 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	67	1.000	Inparanoid score	I3940
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050