DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cact and Nfkbia

DIOPT Version :9

Sequence 1:	NP_001260496.1	Gene:	cact / 34969	FlyBaseID:	FBgn0000250	Length:	500	Species:	Drosophila melanogaster
Sequence 2:	NP_035037.2	Gene:	Nfkbia / 18035	MGIID:	104741	Length:	314	Species:	Mus musculus

Alignment Length:	278	Identity:	97/278 - (34%)
Similarity:	141/278 - (50%)	Gaps:	43/278 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   220 WEQFYQQNDDGDTPLHLACISGSVDVVAALI-RMAPHPCLLNIQNDVAQTPLHLAALTAQPNIMR 283
            |:|  |..:|||:.||||.|.....:...:| ::......||.||::.|||||||.:|.||.|..
Mouse    66 WKQ--QLTEDGDSFLHLAIIHEEKPLTMEVIGQVKGDLAFLNFQNNLQQTPLHLAVITNQPGIAE 128

  Fly   284 ILLLAGAEPTVRDRHGNTALHLSCIAGEKQCVRALTEKFGATEIHEAHRQYGHRSNDKAVSSLSY 348
            .||.||.:|.:||..|||.|||:|   |:.|:                         .:|:.|:.
Mouse   129 ALLKAGCDPELRDFRGNTPLHLAC---EQGCL-------------------------ASVAVLTQ 165

  Fly   349 ACLP----ADLEIRNYDGERCVHLAAEAGHIDILRILVSHGADINAREGKSGRTPLHIAIEGCNE 409
            .|.|    :.|:..||:|..|:|||:..|::.|:..||:.|||:||:|..:|||.||:|::..|.
Mouse   166 TCTPQHLHSVLQATNYNGHTCLHLASIHGYLAIVEHLVTLGADVNAQEPCNGRTALHLAVDLQNP 230

  Fly   410 DLANFLLDECEKLNLETATYAGLTAYQFACIMNKSRMQNILEKRGAET--VTPPDSDYDSSDIED 472
            ||.:.|| :| ..::...||.|.:.||.......:|:|..|.:...|.  :.|...|.:|.|.|.
Mouse   231 DLVSLLL-KC-GADVNRVTYQGYSPYQLTWGRPSTRIQQQLGQLTLENLQMLPESEDEESYDTES 293

  Fly   473 --LDDTKMYDR--FGDPR 486
              .:|...||.  ||..|
Mouse   294 EFTEDELPYDDCVFGGQR 311

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cact	NP_001260496.1	ANK	<225..286	CDD:238125	25/61 (41%)
		ANK repeat	229..263	CDD:293786	11/34 (32%)
		Ank_4	230..286	CDD:290365	23/56 (41%)
		ANK	260..416	CDD:238125	61/159 (38%)
		ANK repeat	265..296	CDD:293786	16/30 (53%)
		Ank_2	270..391	CDD:289560	44/124 (35%)
		ANK repeat	298..324	CDD:293786	9/25 (36%)
		ANK repeat	361..393	CDD:293786	14/31 (45%)
		Ank_5	381..438	CDD:290568	25/56 (45%)
		ANK repeat	395..425	CDD:293786	12/29 (41%)
Nfkbia	NP_035037.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..40
		Ank_2	<26..>151	CDD:330894	39/86 (45%)
		Destruction motif	30..36
		Nuclear export signal. /evidence=ECO:0000250	45..54
		ANK repeat	73..108	CDD:293786	11/34 (32%)
		ANK 1	73..103		9/29 (31%)
		ANK	105..237	CDD:238125	61/159 (38%)
		ANK repeat	110..141	CDD:293786	16/30 (53%)
		ANK 2	110..139		16/28 (57%)
		Nuclear import signal. /evidence=ECO:0000250	110..120		7/9 (78%)
		ANK repeat	143..180	CDD:293786	14/64 (22%)
		ANK 3	143..172		13/56 (23%)
		ANK repeat	182..213	CDD:293786	14/30 (47%)
		ANK 4	182..211		12/28 (43%)
		ANK repeat	216..246	CDD:293786	12/31 (39%)
		ANK 5	216..245		12/30 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846747
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BM8A
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7863
Inparanoid	1	1.050	133	1.000	Inparanoid score	I4587
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1341288at2759
OrthoFinder	1	1.000	-	-		FOG0002150
OrthoInspector	1	1.000	-	-		otm43754
orthoMCL	1	0.900	-	-		OOG6_108699
Panther	1	1.100	-	-	LDO	PTHR46680
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4493
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	11.830