DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fzy and CDH1

DIOPT Version :9

Sequence 1:	NP_477501.1	Gene:	fzy / 34968	FlyBaseID:	FBgn0001086	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_011512.1	Gene:	CDH1 / 852881	SGDID:	S000002971	Length:	566	Species:	Saccharomyces cerevisiae

Alignment Length:	581	Identity:	182/581 - (31%)
Similarity:	275/581 - (47%)	Gaps:	147/581 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 LEASLNGSVNTTRSVLSVSYNTSFSGVQAPTKTPGKSSEGK-------TKKSNTTPSKTPGG--- 85
            :..:||..:|.|                 |:.:|.|.||.|       :..|:.:...:|..
Yeast     1 MSTNLNPFMNNT-----------------PSSSPLKGSESKRVSKRPISSSSSASLLSSPSRRSR 48

  Fly    86 -----GDRFIPNRAATNF------------------------------------------ELAHF 103
                 |||:||:|...:|                                          ||...
Yeast    49 PSTVYGDRYIPSRTDIDFNSIVSISSMASVPALNPSSTEDQVEYQKERQAHETYNTLLKNELFGE 113

  Fly   104 LVNKDS-GDKSDEENDKATSSNSNESNVQA--------------------------SAHK---GD 138
            :::||: |.:|..:..|.|.. |...||.|                          |.|.   ..
Yeast   114 MLSKDTVGSESSIDRIKNTRP-STRGNVHAENTTRHGYELERVSTPPPEAAGLEEFSPHSTPVTP 177

  Fly   139 RQKLISEVAQV-----GDSKGGRILCYQNK-------------------APAAPETHNNPLKVVY 179
            |:...|:..::     ...:|..:|.||.:                   :|..|:
Yeast   178 RRLFTSQQDEITRPSSNSVRGASLLTYQQRKGRRLSAASLLQSQFFDSMSPVRPD---------- 232

  Fly   180 SIKTPISTKSGSRYIPTTSERILDAPDFINDYYLNLMDWSADNIVAVALGSCVYLWNAQTGNIEQ 244
            |.:..:|.....|.|.....|:||||...:|:|.:|:|||:.:::|||||..::|.:..||::..
Yeast   233 SKQLLLSPGKQFRQIAKVPYRVLDAPSLADDFYYSLIDWSSTDVLAVALGKSIFLTDNNTGDVVH 297

  Fly   245 LTEFEEGDYAGSLSWIQEGQILAIGNSTGAVELWDCSKVKRLRVMDGHSARVGSLAWNSFLVSSG 309
            |.: .|.:|. |||||..|..||:|.:.|.||::|..|.|.:|.:.||..||..|:||:.:::||
Yeast   298 LCD-TENEYT-SLSWIGAGSHLAVGQANGLVEIYDVMKRKCIRTLSGHIDRVACLSWNNHVLTSG 360

  Fly   310 SRDGTIVHHDVRAREHKLSTLSGHTQEVCGLKWSTDFKYLASGGNDNLVNVWSAASGGVGTATDP 374
            |||..|:|.|||..:....|:..||||||||||:.....||||||||:|:|:.      ||:..|
Yeast   361 SRDHRILHRDVRMPDPFFETIESHTQEVCGLKWNVADNKLASGGNDNVVHVYE------GTSKSP 419

  Fly   375 LHKFNDHQAAVRALAWCPWQPSTLASGGGTADRCIKFWNVNNGTLMKSVDSKSQVCSLLFSRHYK 439
            :..|::|:|||:|:||.|.:...||:|||||||.:|.||||....|..:||.||:|::::|::..
Yeast   420 ILTFDEHKAAVKAMAWSPHKRGVLATGGGTADRRLKIWNVNTSIKMSDIDSGSQICNMVWSKNTN 484

  Fly   440 ELISAHGFANNQLTIWKYPTMVKQADLTGHTSRVLQMAMSPDGSTVISAGADETLRLWNCF 500
            ||:::||::...||:|...:|...|.|.||:.|||.:.:|.||:||:|...|||||.|..|
Yeast   485 ELVTSHGYSKYNLTLWDCNSMDPIAILKGHSFRVLHLTLSNDGTTVVSGAGDETLRYWKLF 545

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fzy	NP_477501.1	WD40	<208..500	CDD:225201	131/291 (45%)
		WD40	216..498	CDD:238121	127/281 (45%)
		WD40 repeat	256..291	CDD:293791	16/34 (47%)
		WD40 repeat	297..332	CDD:293791	14/34 (41%)
		WD40 repeat	337..373	CDD:293791	18/35 (51%)
		WD40 repeat	386..424	CDD:293791	19/37 (51%)
		WD40 repeat	429..467	CDD:293791	11/37 (30%)
		WD40 repeat	473..513	CDD:293791	15/28 (54%)
CDH1	NP_011512.1	WD40	269..543	CDD:421866	127/281 (45%)
		WD40 repeat	269..300	CDD:293791	12/30 (40%)
		WD40 repeat	305..342	CDD:293791	17/37 (46%)
		WD40 repeat	348..383	CDD:293791	14/34 (41%)
		WD40 repeat	388..424	CDD:293791	19/41 (46%)
		WD40 repeat	431..467	CDD:293791	19/35 (54%)
		WD40 repeat	474..512	CDD:293791	11/37 (30%)
		WD40 repeat	518..544	CDD:293791	14/25 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	52	1.000	Domainoid score	I2832
eggNOG	1	0.900	-	-		E2759_KOG0305
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000628
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.810