DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fzy and CDC20.2

DIOPT Version :9

Sequence 1:	NP_477501.1	Gene:	fzy / 34968	FlyBaseID:	FBgn0001086	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_195052.1	Gene:	CDC20.2 / 829462	AraportID:	AT4G33260	Length:	447	Species:	Arabidopsis thaliana

Alignment Length:	446	Identity:	207/446 - (46%)
Similarity:	284/446 - (63%)	Gaps:	38/446 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 KTKKSNTTPSKTPGGGDRFIPNRAATNFELAHFLVNKDSGDKSDEENDKATSSNSNESNVQASAH 135
            |..|.|.         |||||||:|.||:.|||.:.:   ::..::.....||.|.|:
plant    18 KNSKENL---------DRFIPNRSAMNFDYAHFALTE---ERKGKDQSATVSSPSKEA------- 63

  Fly   136 KGDRQKLISEVAQVGDSKGGRILCYQNKAPA----APETHNNPLKVVYSIKTPISTKSGSRYIPT 196
               .:|.::|...:..:   |||.::||..|    .|..|:..|.     :.|.|.|. .||||.
plant    64 ---YRKQLAETMNLNHT---RILAFRNKPQAPVELLPSNHSASLH-----QQPKSVKP-RRYIPQ 116

  Fly   197 TSERILDAPDFINDYYLNLMDWSADNIVAVALGSCVYLWNAQTGNIEQL-TEFEEGDYAGSLSWI 260
            ||||.|||||.::|:||||:||.:.|::|:||...||||:|.||:..:| |..||.....|::|.
plant   117 TSERTLDAPDIVDDFYLNLLDWGSANVLAIALDHTVYLWDASTGSTSELVTIDEEKGPVTSINWA 181

  Fly   261 QEGQILAIGNSTGAVELWDCSKVKRLRVM-DGHSARVGSLAWNSFLVSSGSRDGTIVHHDVRARE 324
            .:|:.:|:|.:...|:|||.:..::||.: .||.:||||||||:.::::|..||.|:::|||.|.
plant   182 PDGRHVAVGLNNSEVQLWDSASNRQLRTLKGGHQSRVGSLAWNNHILTTGGMDGLIINNDVRIRS 246

  Fly   325 HKLSTLSGHTQEVCGLKWSTDFKYLASGGNDNLVNVWSAASGGVGTATDPLHKFNDHQAAVRALA 389
            ..:.|..||||||||||||...:.||||||||:|::|..:.....:.|..||:..:|.:||:|||
plant   247 PIVETYRGHTQEVCGLKWSGSGQQLASGGNDNVVHIWDRSVASSNSTTQWLHRLEEHTSAVKALA 311

  Fly   390 WCPWQPSTLASGGGTADRCIKFWNVNNGTLMKSVDSKSQVCSLLFSRHYKELISAHGFANNQLTI 454
            |||:|.:.||:|||..||.|||||.:.|..:.|||:.|||||||:|::.:||:|:|||..||||:
plant   312 WCPFQANLLATGGGGGDRTIKFWNTHTGACLNSVDTGSQVCSLLWSKNERELLSSHGFTQNQLTL 376

  Fly   455 WKYPTMVKQADLTGHTSRVLQMAMSPDGSTVISAGADETLRLWNCFAPDPLASKKA 510
            ||||:|||.|:|||||||||.||.||||.||.||..|||||.||.|.. |..:|||
plant   377 WKYPSMVKMAELTGHTSRVLYMAQSPDGCTVASAAGDETLRFWNVFGV-PETAKKA 431

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fzy	NP_477501.1	WD40	<208..500	CDD:225201	155/293 (53%)
		WD40	216..498	CDD:238121	148/283 (52%)
		WD40 repeat	256..291	CDD:293791	11/35 (31%)
		WD40 repeat	297..332	CDD:293791	15/34 (44%)
		WD40 repeat	337..373	CDD:293791	17/35 (49%)
		WD40 repeat	386..424	CDD:293791	21/37 (57%)
		WD40 repeat	429..467	CDD:293791	24/37 (65%)
		WD40 repeat	473..513	CDD:293791	24/38 (63%)
CDC20.2	NP_195052.1	WD40	<139..425	CDD:225201	149/286 (52%)
		WD40	149..420	CDD:238121	142/270 (53%)
		WD40 repeat	175..212	CDD:293791	11/36 (31%)
		WD40 repeat	219..254	CDD:293791	15/34 (44%)
		WD40 repeat	259..301	CDD:293791	20/41 (49%)
		WD40 repeat	308..346	CDD:293791	21/37 (57%)
		WD40 repeat	351..389	CDD:293791	24/37 (65%)
		WD40 repeat	395..421	CDD:293791	18/25 (72%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	103	1.000	Domainoid score	I2251
eggNOG	1	0.900	-	-		E2759_KOG0305
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	391	1.000	Inparanoid score	I496
OMA	1	1.010	-	-		QHG54440
OrthoDB	1	1.010	-	-		D1220675at2759
OrthoFinder	1	1.000	-	-		FOG0000628
OrthoInspector	1	1.000	-	-		otm3270
orthoMCL	1	0.900	-	-		OOG6_101791
Panther	1	1.100	-	-	LDO	PTHR19918
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1762
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.840