DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fzy and FZR2

DIOPT Version :9

Sequence 1:	NP_477501.1	Gene:	fzy / 34968	FlyBaseID:	FBgn0001086	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_194022.3	Gene:	FZR2 / 828390	AraportID:	AT4G22910	Length:	483	Species:	Arabidopsis thaliana

Alignment Length:	520	Identity:	206/520 - (39%)
Similarity:	289/520 - (55%)	Gaps:	77/520 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 TTRSVLSVSYNTSFSGVQAPTKTPGKSSEGKTKK---SNTTPSKTPGG------GDRFIPNRAAT 96
            |..:|::.|.::|...:.....||..|.|.:..:   :|.:.|.:|..      .|||||:|:.:
plant     7 TASNVITNSNSSSMRNLSPAMNTPVVSLESRINRLINANQSQSPSPSSLSRSIYSDRFIPSRSGS 71

  Fly    97 NFELAHFLVNKDSGDKSDEENDKAT--------------------SSNSNESNVQASAHKGDRQK 141
            ||.|.....:.....|.|.....||                    ||:.|....:...|:.
plant    72 NFALFDLSPSPSKDGKEDGAGSYATLLRAAMFGPETPEKRDITGFSSSRNIFRFKTETHRS---- 132

  Fly   142 LISEVAQVG---DSKGGRILCYQNKAPAAPETHNNPLKVVYSIKTPISTKSGSRYIPTTSERILD 203
             ::..:..|   ||.|              .:|:.|      :|.|       |.:|.:..::||
plant   133 -LNSFSPFGVDDDSPG--------------VSHSGP------VKAP-------RKVPRSPYKVLD 169

  Fly   204 APDFINDYYLNLMDWSADNIVAVALGSCVYLWNAQTGNIEQLTEFEEGDYAGSLSWIQEGQILAI 268
            ||...:|:||||:||||.|::||.||:|||||||.:..:.:|.:....|...|:.|...|..||:
plant   170 APALQDDFYLNLVDWSAQNVLAVGLGNCVYLWNACSSKVTKLCDLGAEDSVCSVGWALRGTHLAV 234

  Fly   269 GNSTGAVELWDCSKVKRLRVMDGHSARVGSLAWNSFLVSSGSRDGTIVHHDVRAREHKLSTLSGH 333
            |.|||.|::||.|:.||.|.|:||..|||:|||.|.::||||||.:|:..|:|.:|..:|.|:||
plant   235 GTSTGKVQIWDASRCKRTRTMEGHRLRVGALAWGSSVLSSGSRDKSILQRDIRCQEDHVSKLAGH 299

  Fly   334 TQEVCGLKWSTDFKYLASGGNDNLVNVWSAASGGVGTATDPLHKFNDHQAAVRALAWCPWQPSTL 398
            ..||||||||.|.:.||||||||.:.||:..|      |.|:.|:::|.|||:|:||.|.....|
plant   300 KSEVCGLKWSYDNRELASGGNDNRLFVWNQHS------TQPVLKYSEHTAAVKAIAWSPHVHGLL 358

  Fly   399 ASGGGTADRCIKFWNVNNGTLMKSVDSKSQVCSLLFSRHYKELISAHGFANNQLTIWKYPTMVKQ 463
            |||||||||||:|||....|.:.|:|:.||||:|.:|::..||:|.||::.||:.:||||||.|.
plant   359 ASGGGTADRCIRFWNTTTNTHLSSIDTCSQVCNLAWSKNVNELVSTHGYSQNQIIVWKYPTMSKI 423

  Fly   464 ADLTGHTSRVLQMAMSPDGSTVISAGADETLRLWNCFAPDPLASKKAVSTSKGKQSVF--RQSIR 526
            |.|||||.|||.:|:||||.|:::...|||||.||.| |.|    |:.:|.....|.|  |.:||
plant   424 ATLTGHTYRVLYLAVSPDGQTIVTGAGDETLRFWNVF-PSP----KSQNTDSEIGSSFFGRTTIR 483

Fly 527 526
plant 484 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fzy	NP_477501.1	WD40	<208..500	CDD:225201	154/291 (53%)
		WD40	216..498	CDD:238121	147/281 (52%)
		WD40 repeat	256..291	CDD:293791	17/34 (50%)
		WD40 repeat	297..332	CDD:293791	17/34 (50%)
		WD40 repeat	337..373	CDD:293791	19/35 (54%)
		WD40 repeat	386..424	CDD:293791	21/37 (57%)
		WD40 repeat	429..467	CDD:293791	19/37 (51%)
		WD40 repeat	473..513	CDD:293791	19/39 (49%)
FZR2	NP_194022.3	WD40	182..458	CDD:421866	147/281 (52%)
		WD40 repeat	220..257	CDD:293791	17/36 (47%)
		WD40 repeat	263..298	CDD:293791	17/34 (50%)
		WD40 repeat	303..339	CDD:293791	22/41 (54%)
		WD40 repeat	346..384	CDD:293791	21/37 (57%)
		WD40 repeat	389..427	CDD:293791	19/37 (51%)
		WD40 repeat	433..459	CDD:293791	14/25 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0305
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54440
OrthoDB	1	1.010	-	-		D1220675at2759
OrthoFinder	1	1.000	-	-		FOG0000628
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.830