DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fzy and Fzr1

DIOPT Version :9

Sequence 1:	NP_477501.1	Gene:	fzy / 34968	FlyBaseID:	FBgn0001086	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_001101544.2	Gene:	Fzr1 / 314642	RGDID:	1308713	Length:	493	Species:	Rattus norvegicus

Alignment Length:	489	Identity:	194/489 - (39%)
Similarity:	286/489 - (58%)	Gaps:	52/489 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 VQAPTKTPGKSSEGKTKKSNTTPSKTPG-GGDRFIPNRAATNFELAHFLVNKDSGDKSDEENDK- 119
            :|.....|..|...:|.....:|..:|. .||||||:||..|:.:....:|::  :||..:|.|
  Rat    15 IQNENTVPCVSEMRRTLTPANSPVSSPSKHGDRFIPSRAGANWSVNFHRINEN--EKSPSQNRKA 77

  Fly   120 --ATSSNSNESNVQASAHKGDRQKLISEVAQVGDSKGGRILCYQNKAPAAPETHNNPLKVVYSIK 182
              |||.|..:....::..|.:......|..|...::..|:      .|:.|| |........|.|
  Rat    78 KDATSDNGKDGLAYSALLKNELLGAGIEKVQDPQTEDRRL------QPSTPE-HKGLFTYSLSSK 135

  Fly   183 ---------------TPISTKS---------GSRYIPTTSERILDAPDFINDYYLNLMDWSADNI 223
                           :|:|.||         .:|.|.....::||||:..:|:||||:|||:.|:
  Rat   136 RSSPDDGNDVSPYSLSPVSNKSQKLLRSPRKPTRKISKIPFKVLDAPELQDDFYLNLVDWSSLNV 200

  Fly   224 VAVALGSCVYLWNAQTGNIEQLTEFE-EGDYAGSLSWIQEGQILAIGNSTGAVELWDCSKVKRLR 287
            ::|.||:|||||:|.|..:.:|.:.. |||...|:.|.:.|.::|:|...|.|::||.:..|:|.
  Rat   201 LSVGLGTCVYLWSACTSQVTRLCDLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLS 265

  Fly   288 VMDGHSARVGSLAWNSFLVSSGSRDGTIVHHDVRA----REHKLSTLSGHTQEVCGLKWSTDFKY 348
            |::||:||||:||||:..:||||||..|:..|:|.    .|.:   |.||.|||||||||||.:.
  Rat   266 VLEGHTARVGALAWNADQLSSGSRDRMILQRDIRTPALQSERR---LQGHRQEVCGLKWSTDHQL 327

  Fly   349 LASGGNDNLVNVWSAASGGVGTATDPLHKFNDHQAAVRALAWCPWQPSTLASGGGTADRCIKFWN 413
            ||||||||.:.||:.:|      ..|:.::.:|.|||:|:||.|.|...||||||||||||:|||
  Rat   328 LASGGNDNKLLVWNHSS------LSPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWN 386

  Fly   414 VNNGTLMKSVDSKSQVCSLLFSRHYKELISAHGFANNQLTIWKYPTMVKQADLTGHTSRVLQMAM 478
            ...|..::.:|:.||||:|.:|:|..||:|.||::.||:.:||||::.:.|.||||:.|||.:||
  Rat   387 TLTGQPLQCIDTGSQVCNLAWSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAM 451

  Fly   479 SPDGSTVISAGADETLRLWNCFAPDPLASKKAVS 512
            ||||..:::...|||||.||.|: ...::|::||
  Rat   452 SPDGEAIVTGAGDETLRFWNVFS-KTRSTKESVS 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fzy	NP_477501.1	WD40	<208..500	CDD:225201	146/296 (49%)
		WD40	216..498	CDD:238121	139/286 (49%)
		WD40 repeat	256..291	CDD:293791	12/34 (35%)
		WD40 repeat	297..332	CDD:293791	16/38 (42%)
		WD40 repeat	337..373	CDD:293791	20/35 (57%)
		WD40 repeat	386..424	CDD:293791	21/37 (57%)
		WD40 repeat	429..467	CDD:293791	17/37 (46%)
		WD40 repeat	473..513	CDD:293791	19/40 (48%)
Fzr1	NP_001101544.2	WD40	193..471	CDD:238121	139/286 (49%)
		WD40 repeat	232..269	CDD:293791	12/36 (33%)
		WD40 repeat	275..311	CDD:293791	16/38 (42%)
		WD40 repeat	316..352	CDD:293791	21/41 (51%)
		WD40 repeat	359..397	CDD:293791	21/37 (57%)
		WD40 repeat	402..440	CDD:293791	17/37 (46%)
		WD40 repeat	446..487	CDD:293791	19/40 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0305
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54440
OrthoDB	1	1.010	-	-		D1220675at2759
OrthoFinder	1	1.000	-	-		FOG0000628
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.830